Studies on polynucleotides

A ribopolynucleotide containing the repeating trinucleotide sequence, adenylyl-adenylyl-guanylate (poly AAG) has been shown to direct the synthesis of polyly-sine, polyarginine and polyglutamate in the in vitro amino acid incorporation system. In experiments on the stimulation of the binding of [ 14 C]aminoacyl-sRNA to ribosomes the following results were obtained. (1) Poly AAG stimulated the binding of lysyl-, glutamyl-, arginyl- and aspartyl-sRNA. (2) The trinucleotide, GpApA, was specific in inducing the binding of glutamyl-sRNA and the trinucleotide, ApApG, was specific in inducing.the binding of lysyl-sRNA to ribosomes. The new codon sequences ApApG for lysine and GpApA for glutamic acid are therefore proposed. (3) The codon sequence ApGpA is proposed for arginine, despite the failure of this trinucleotide to stimulate the binding of arginyl-sRNA to ribosomes. (4) GpApA also stimulated the binding of aspartyl-sRNA to ribosomes. In the in vitro amino acid incorporation experiments, however, no polyaspartate synthesis has so far been detected in the presence of poly AAG.

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