Neuroplasticity as a foundation for human enhancements in space

Abstract The space medicine literature reports changes in neurological systems of astronauts after spaceflight, which has caused understandable concern. Rehabilitative medicine provides a preliminary context to address these changes and creative efforts in preflight training and post-flight remediation have resulted. Research can now begin to determine the neurological changes that are most and least debilitating, the most and least reversible, and which can be tolerated as an adaptation to space. It is not yet known which changes will require remediation with the help of human enhancements, or the type (genetic, pharmacological, prosthetic) when crew venture on long voyages to Mars, the asteroids, and outer planets. Absent from the discussion to date is the biological basis for neuroplastic changes in spaceflight—genetic, developmental, and evolutionary—especially insights from genomics experts and paleobiologists that suggest advantages. Humans are flexible, adaptive, and in many ways, well suited for space with the help of enhancements. Their neurological plasticity provides an almost unique foundation in the animal kingdom for genetic engineering, medication management, and remediation, so enhancements can be integrated naturally into human bodies, lives, and work. Here, the authors explore the nature of human neuroplasticity as a foundation for use of human enhancements.

[1]  Steven Laureys,et al.  Spaceflight-induced neuroplasticity in humans as measured by MRI: what do we know so far? , 2017, npj Microgravity.

[2]  J. Bloomberg,et al.  Brain structural plasticity with spaceflight , 2016, npj Microgravity.

[3]  L. Ferrucci,et al.  Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging , 2015, Journal of the American Geriatrics Society.

[4]  A. Schreurs,et al.  A human mission to Mars: Predicting the bone mineral density loss of astronauts , 2020, PloS one.

[5]  B. Hare,et al.  The self-domestication hypothesis: evolution of bonobo psychology is due to selection against aggression , 2012, Animal Behaviour.

[6]  A. O. Sasmita,et al.  Harnessing neuroplasticity: modern approaches and clinical future , 2018, The International journal of neuroscience.

[7]  E. Korpi,et al.  Neurosteroid Agonist at GABAA Receptor Induces Persistent Neuroplasticity in VTA Dopamine Neurons , 2014, Neuropsychopharmacology.

[8]  S. Harkema,et al.  Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. , 2014, Brain : a journal of neurology.

[9]  D. Eckberg,et al.  Human Autonomic Responses to Actual and Simulated Weightlessness , 1991, Journal of clinical pharmacology.

[10]  Margaret Boone Rappaport,et al.  Normalizing the Paradigm on Human Enhancements for Spaceflight , 2020 .

[11]  H. Gunga,et al.  Decision making after 50 days of simulated weightlessness , 2009, Brain Research.

[12]  Takao K. Hensch,et al.  Re-opening Windows: Manipulating Critical Periods for Brain Development , 2012, Cerebrum : the Dana forum on brain science.

[13]  M. Rappaport,et al.  Evolution of religious capacity in the genus homo: Trait complexity in action through compassion , 2018 .

[14]  Michael L. Anderson.  Neural reuse: A fundamental organizational principle of the brain , 2010, Behavioral and Brain Sciences.

[15]  Shihui Han,et al.  A Culture–Behavior–Brain Loop Model of Human Development , 2015, Trends in Cognitive Sciences.

[16]  Todd M. Preuss,et al.  Human brain evolution , 1999 .

[17]  Fabien B. Wagner,et al.  Targeted neurotechnology restores walking in humans with spinal cord injury , 2018, Nature.

[18]  A. Sargsyan,et al.  Intracranial Effects of Microgravity: A Prospective Longitudinal MRI Study. , 2020, Radiology.

[19]  H. Clark Barrett,et al.  Evolution of cognition : An adaptationist perspective , 2001 .

[20]  Margaret Boone Rappaport,et al.  Changing the Paradigm on Human Enhancements: The Special Case of Modifications to Counter Bone Loss for Manned Mars Missions , 2019, Space Policy.

[21]  Constance Scharff,et al.  FOXP2 as a molecular window into speech and language. , 2009, Trends in genetics : TIG.

[22]  Michael Ramscar,et al.  Cognition Without Control When a Little Frontal Lobe Goes a Long Way , 2009 .

[23]  C. Phillips.  Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging , 2017, Neural plasticity.

[24]  Richard P. Binzel,et al.  Human spaceflight: Find asteroids to get to Mars , 2014, Nature.

[25]  张静,et al.  Banana Ovate family protein MaOFP1 and MADS-box protein MuMADS1 antagonistically regulated banana fruit ripening , 2015 .

[26]  Michael W. Cole,et al.  Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks , 2017, Proceedings of the National Academy of Sciences.

[27]  C. Sherwood,et al.  Brain Plasticity and Human Evolution , 2017 .

[28]  L. Rothschild,et al.  A Makerspace for Life Support Systems in Space. , 2019, Trends in biotechnology.

[29]  Michael L. Anderson.  Circuit sharing and the implementation of intelligent systems , 2008, AAAI Fall Symposium: Biologically Inspired Cognitive Architectures.

[30]  Daniel J. Chandler,et al.  Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System , 2018, Neural plasticity.

[31]  Jan Sijbers,et al.  The effect of spaceflight and microgravity on the human brain , 2017, Journal of Neurology.

[32]  Steven Laureys,et al.  Brain ventricular volume changes induced by long-duration spaceflight , 2019, Proceedings of the National Academy of Sciences.

[33]  Karenleigh A. Overmann,et al.  Visuospatial integration: Paleoanthropological and archaeological perspectives , 2021 .

[34]  P. Bach-y-Rita,et al.  Sensory substitution and the human–machine interface , 2003, Trends in Cognitive Sciences.

[35]  K. Szocik.  Should and could humans go to Mars? Yes, but not now and not in the near future , 2019, Futures.

[36]  Kenneth R. Foster,et al.  Risk-Benefit Analysis , 2002 .

[37]  T. K. Altheide,et al.  Comparing the human and chimpanzee genomes: Searching for needles in a haystack , 2005 .

[38]  G M Sandal.  Psychosocial issues in space: future challenges. , 2001, Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology.

[39]  Michael L. Anderson,et al.  Allocating structure to function: the strong links between neuroplasticity and natural selection , 2014, Front. Hum. Neurosci..

[40]  G. Fond,et al.  Nanopsychiatry—The potential role of nanotechnologies in the future of psychiatry: A systematic review , 2013, European Neuropsychopharmacology.

[41]  K. Slenzka.  Neuroplasticity changes during space flight. , 2003, Advances in space research : the official journal of the Committee on Space Research.

[42]  Martin Braddock,et al.  Concepts for Deep Space Travel: From Warp Drives and Hibernation to World Ships and Cryogenics , 2018 .

[43]  Johannes Schwarz,et al.  A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice , 2009, Cell.

[44]  Enrico Amico,et al.  Cortical reorganization in an astronaut’s brain after long-duration spaceflight , 2015, Brain Structure and Function.

[45]  M. Rappaport,et al.  EVOLUTION OF RELIGIOUS CAPACITY IN THE GENUS HOMO: COGNITIVE TIME SEQUENCE , 2018 .

[46]  A. Newberg,et al.  Changes in the central nervous system and their clinical correlates during long-term spaceflight. , 1994, Aviation, space, and environmental medicine.

[47]  Sam Salek,et al.  A quantitative approach to benefit‐risk assessment of medicines – part 1: the development of a new model using multi‐criteria decision analysis , 2007, Pharmacoepidemiology and drug safety.

[48]  M. Nitsche,et al.  Serotonin Affects Transcranial Direct Current–Induced Neuroplasticity in Humans , 2009, Biological Psychiatry.

[49]  Lianne H. Scholtens,et al.  Evolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees , 2019, Proceedings of the National Academy of Sciences.

[50]  A. Lundervold,et al.  High-expanding cortical regions in human development and evolution are related to higher intellectual abilities. , 2015, Cerebral cortex.

[51]  M. Rappaport,et al.  Program Planning for a Mars Hardship Post: Social, Psychological, and Spiritual Services , 2019, The Human Factor in a Mission to Mars.

[52]  C. Sherwood,et al.  Relaxed genetic control of cortical organization in human brains compared with chimpanzees , 2015, Proceedings of the National Academy of Sciences.