Detection of the (–SEA) double α‐globin gene deletion by a simple immunologic assay for embryonic ζ‐globin chains

Homozygous α‐thalassemia [α‐thal‐1], with loss of all four α‐globin genes, causes lethal hydrops fetalis. The most common mutation producing this syndrome is the Southeast Asian (–SEA) double α‐globin gene deletion. Erythrocytes from adults heterozygous for the (–SEA) deletion have minute amounts of embryonic ζ‐globin chains detectable by anti‐ζ‐globin monoclonal antibodies.

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