Synthesis and photoisomerization of an azobenzene derivative bearing two β-cyclodextrin units at both ends

An azobenzene deriovative with two β-cyclodextrin units was synthesized as a novel photoswitchable host. It undergoes trans-to-cis photoisomerization in aqueous solution with 65.8% cis at the photostationary state and returns to the original trans form with half life of 54,8 h at 25°C. It axhibits circular dichroism bands in the π-π * and n-π * absorption regions of azobenzene in spite of the fact that the azobenzene unit cannot be included in the cyclodextrin cavity and their absolute dichroism intensities of the cis form become much larger than those of trans one