Volumetric abnormalities of thalamic subnuclei in medication-overuse headache

BackgroundThe thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse headache (MOH). The aim of this study is to investigate altered thalamic subnuclei volume in MOH compared with normal controls, and to evaluate the relationship of each thalamic subnuclei volume with the clinical variables.MethodsHigh resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 27 patients with MOH and 27 normal controls (NC). Thalamic subnuclei templates were created based on Talairach template with MNI space transformation, and the individual thalamic subnuclei templates were generated by applying the deformation field from structural image segment to the thalamic subnuclei templates, and then individual thalamci subnuclei volume were calculated.ResultsThe whole thalamus and each thalamic subnuclei presented increased volume compared with NC (P < 0.05). The correlation analysis demonstrated that the whole thalamus volume and each thalamic subnuclei volume showed a negative relationship with HAMD scores(P < 0.05), and no any correlation with HAMA, VAS score and disease duration (P > 0.05).ConclusionIncreased gray matter volume in the whole thalamus and all the thalamus subnuclei may reflect central sensitization and higher-order of pain alteration in MOH. These structural changes in the thalamus may also be influenced by mood disturbances related to the MOH.

[1]  H. Hoff,et al.  [Thalamus and pain]. , 1953, Acta neurovegetativa.

[2]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.

[3]  I. Heuser,et al.  The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders. , 1988, Journal of affective disorders.

[4]  M. Bousser,et al.  Psychiatric Comorbidity Is Related to Headache Induced By Chronic Substance Use in Migraineurs , 1999, Headache.

[5]  L. Kurlowicz,et al.  The Mini Mental State Examination (MMSE). , 1999, Director.

[6]  J L Lancaster,et al.  Automated Talairach Atlas labels for functional brain mapping , 2000, Human brain mapping.

[7]  L. Stovner,et al.  Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study , 2003, European journal of neurology.

[8]  P. Goadsby,et al.  Does Chronic Daily Headache Arise De Novo in Association With Regular Use of Analgesics? , 2003, Headache.

[9]  David S Tuch,et al.  Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging , 2003, NeuroImage.

[10]  Karl J. Friston,et al.  A positron emission tomographic study in spontaneous migraine. , 2005, Archives of neurology.

[11]  V. Dousset,et al.  Psychiatric Comorbidity in the Evolution From Migraine to Medication Overuse Headache , 2005, Cephalalgia : an international journal of headache.

[12]  Bogdan Draganski,et al.  Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients , 2006, Pain.

[13]  Xiaoling Li,et al.  Thalamus Segmentation from Diffusion Tensor Magnetic Resonance Imaging , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[14]  H. Diener,et al.  Central Sensitization of The Trigeminal and Somatic Nociceptive Systems in Medication Overuse Headache Mainly Involves Cerebral Supraspinal Structures , 2006, Cephalalgia : an international journal of headache.

[15]  J. Olesen.  The International Classification of Headache Disorders , 2008, Headache.

[16]  A. May.  Morphing voxels: the hype around structural imaging of headache patients. , 2009, Brain : a journal of neurology.

[17]  P. Calabresi,et al.  Obsessive‐Compulsive Disorder and Migraine With Medication‐Overuse Headache , 2009, Headache.

[18]  N. Sethi.  EXCESSIVE ACUTE MIGRAINE MEDICATION USE AND MIGRAINE PROGRESSION , 2009, Neurology.

[19]  P. Calabresi,et al.  Migraine and psychiatric comorbidity: a review of clinical findings , 2011, The Journal of Headache and Pain.

[20]  S. Evers,et al.  Clinical features, pathophysiology, and treatment of medication-overuse headache , 2010, The Lancet Neurology.

[21]  Xi-Nian Zuo,et al.  REST: A Toolkit for Resting-State Functional Magnetic Resonance Imaging Data Processing , 2011, PloS one.

[22]  M. Lanteri-Minet,et al.  Quality of life impairment, disability and economic burden associated with chronic daily headache, focusing on chronic migraine with or without medication overuse: A systematic review , 2011, Cephalalgia : an international journal of headache.

[23]  S. Bongsebandhu-Phubhakdi,et al.  Pathophysiology of Medication-overuse Headache: Implications from Animal Studies , 2012, Current Pain and Headache Reports.

[24]  S. Kollias,et al.  Grey matter changes associated with medication-overuse headache: Correlations with disease related disability and anxiety , 2012, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[25]  T. Steiner,et al.  The Prevalence and Burden of Primary Headaches in China: A Population‐Based Door‐to‐Door Survey , 2012, Headache.

[26]  T. Steiner,et al.  Risk factors for medication-overuse headache: An 11-year follow-up study. The Nord-Trøndelag Health Studies , 2012, PAIN.

[27]  J. Poulet,et al.  Thalamic control of cortical states , 2012, Nature Neuroscience.

[28]  David Borsook,et al.  Neurological diseases and pain. , 2012, Brain : a journal of neurology.

[29]  E. Benarroch,et al.  Anterior nucleus of the thalamus , 2013, Neurology.

[30]  L. Bendtsen,et al.  Modulation of central sensitisation by detoxification in MOH: Results of a 12-month detoxification study , 2013, Cephalalgia : an international journal of headache.

[31]  R. Ohrbach,et al.  The International Classification of Headache Disorders, 3rd edition (beta version) , 2013, Cephalalgia : an international journal of headache.

[32]  C. Lundqvist,et al.  Medication-overuse headache: a review , 2014, Journal of pain research.

[33]  C. Granziera,et al.  Structural abnormalities in the thalamus of migraineurs with aura: A multiparametric study at 3 T , 2014, Human brain mapping.

[34]  C. S. Hubbard,et al.  Altered Brain Structure and Function Correlate with Disease Severity and Pain Catastrophizing in Migraine Patients , 2014, eNeuro.

[35]  Y. Korogi,et al.  [Anatomy of the Thalamus]. , 2015, Brain and nerve = Shinkei kenkyu no shinpo.

[36]  Till Sprenger,et al.  Morphological Abnormalities of Thalamic Subnuclei in Migraine: A Multicenter MRI Study at 3 Tesla , 2015, The Journal of Neuroscience.

[37]  Mengqi Liu,et al.  Volume gain of periaqueductal gray in medication-overuse headache , 2017, The Journal of Headache and Pain.

[38]  Mengqi Liu,et al.  Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI , 2017, The Journal of Headache and Pain.