Human Health Risk Assessment to the Consumption of Medicinal Plants with Melliferous Potential from the Romanian South-Eastern Region

This study presents the impact on human health by consuming medicinal herbs with high melliferous potential (HMPs) from botanical areas with different pollution levels. First, the bioaccumulation of the plants’ parts has been determined. The study assessed the potential health risks associated with the ingestion of various mineral species (macroelements—K, Ca, Mg, Na; microelements—Fe, Mn, Cu, Zn, and one trace element Cd) from three types of HMPs (Sambucus nigra (SnL), Hypericum perforatum (Hp), and Tilia tomentosa (Tt)). The average concentrations of these elements were not similar even in the same type of HMPs. Nevertheless, all samples contained detectable levels of the studied elements. The average concentrations of the studied elements were very low (significantly lower than the legal limit set by the WHO). The study’s findings indicated that the potential health risks associated with ingesting the elements in HMPs were within acceptable limits for children and adults. The hazard quotient (HQ) for Fe, Mn, Cu, Zn, and Cd and the hazard index (HI) for the minerals from HMPs were significantly lower than the acceptable limit (HQ and HI = 1). Similarly, the carcinogenic risk for chemical substances (Riskccs) were lower than or close to the acceptable limit (1 × 10−4).

[1]  M. Petkova,et al.  Plant Traits of Tilia tomentosa Moench, Fraxinus excelsior L., and Pinus nigra J.F.Arnold as a Proxy of Urbanization , 2023, Forests.

[2]  T. Minkina,et al.  The Content of Heavy Metals in Medicinal Plants in Various Environmental Conditions: A Review , 2023, Horticulturae.

[3]  R. Akhbarizadeh,et al.  Metal(loid)s in herbal medicines and their infusions: Levels, transfer rate, and potential risks to human health , 2022, Hygiene and Environmental Health Advances.

[4]  A. Adebayo,et al.  Major chemical carcinogens and health exposure risks in some therapeutic herbal plants in Nigeria , 2022, PloS one.

[5]  Vikas Nanda,et al.  A review on Api-products: current scenario of potential contaminants and their food safety concerns , 2022, Food Control.

[6]  K. Sharafi,et al.  Analysis of minerals and toxic elements in high-consumption herbal medicine in Zahedan, Iran, and associated human health risk assessment. , 2022, Journal of food protection.

[7]  Tamene Beshaw,et al.  Levels and health risk assessment of trace metals in honey from different districts of Bench Sheko Zone, Southwest Ethiopia , 2022, Heliyon.

[8]  Mihaela Roșca,et al.  Medicinal Plant Growth in Heavy Metals Contaminated Soils: Responses to Metal Stress and Induced Risks to Human Health , 2022, Toxics.

[9]  L. Severino,et al.  Dietary exposure to heavy metals through polyfloral honey from Campania region (Italy) , 2022, Journal of Food Composition and Analysis.

[10]  A. Bărbulescu,et al.  Impact of Soil Pollution on Melliferous Plants , 2022, Toxics.

[11]  Wei Wang,et al.  Comparison and Risk Assessment of Macroelements and Trace Metals in Commercial Teas from Different Regions of China , 2022, Biological Trace Element Research.

[12]  J. Bernal,et al.  Recent trends in the analysis of honey constituents. , 2022, Food chemistry.

[13]  R. Zamir,et al.  An Insight into Pathway and Health Risk Assessment of Toxic Metals in Herbal Medicine , 2022, Journal of Chemistry.

[14]  Manuela Ghica,et al.  Quality Control of Different Types of Honey and Propolis Collected from Romanian Accredited Beekeepers and Consumer’s Risk Assessment , 2022, Crystals.

[15]  R. Pomykała,et al.  Changes in soil pH and mobility of heavy metals in contaminated soils , 2021, European Journal of Soil Science.

[16]  M. Stupar,et al.  Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia , 2021, Journal of Food Composition and Analysis.

[17]  Y. Vander Heyden,et al.  Natural plant toxins in honey: An ignored threat to human health. , 2021, Journal of hazardous materials.

[18]  J. Olusola,et al.  Heavy Metals and Health Risks Associated with Consumption of Herbal Plants Sold in a Major Urban Market in Southwest, Nigeria , 2021, Journal of health & pollution.

[19]  G. Tóth,et al.  Understanding Potential Heavy Metal Contamination, Absorption, Translocation and Accumulation in Rice and Human Health Risks , 2021, Plants.

[20]  V. Nascimento,et al.  Health Hazard Assessment Due to Slimming Medicinal Plant Intake , 2021, Biological Trace Element Research.

[21]  Mayara Schulz,et al.  Quality, composition and health-protective properties of citrus honey: A review. , 2021, Food research international.

[22]  M. Custodio,et al.  Determination of toxic metals in commonly consumed medicinal plants largely used in Peru by ICP-MS and their impact on human health , 2021 .

[23]  Manqun Wang,et al.  Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications , 2021, Toxics.

[24]  H. Kassahun,et al.  Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia , 2020 .

[25]  S. Girotti,et al.  Bioindicators and biomonitoring: honeybees and hive products as pollution impact assessment tools for the Mediterranean area , 2020, Euro-Mediterranean Journal for Environmental Integration.

[26]  S. Teodorescu,et al.  Heavy metals accumulation and translocation in native plants grown on tailing dumps and human health risk , 2020, Plant and Soil.

[27]  Shilin Chen,et al.  Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions , 2020, Frontiers in Pharmacology.

[28]  Decong Xu,et al.  Interactions between heavy metals and other mineral elements from soil to medicinal plant Fengdan (Paeonia ostii) in a copper mining area, China , 2020, Environmental Science and Pollution Research.

[29]  M. Tomczyk,et al.  Transfer of Some Toxic Metals from Soil to Honey Depending on Bee Habitat Conditions , 2020, Acta Universitatis Cibiniensis. Series E: Food Technology.

[30]  A. M. Abbasi,et al.  Evaluation of heavy metals in cosmetic products and their health risk assessment , 2020, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[31]  K. Kim,et al.  What Is COVID-19? , 2020, Frontiers for Young Minds.

[32]  I. Vlad,et al.  Heavy Metal Content in PolyfloralHoney and Potential Health Risk. A Case Study of Copșa Mică, Romania , 2020, International journal of environmental research and public health.

[33]  S. D. Inglez,et al.  Fast and effective simultaneous determination of metals in soil samples by ultrasound-assisted extraction and flame atomic absorption spectrometry: assessment of trace elements contamination in agricultural and native forest soils from Paraná - Brazil , 2020, Environmental Monitoring and Assessment.

[34]  Jonathan A. G. Cox,et al.  Dissecting the Antimicrobial Composition of Honey , 2019, Antibiotics.

[35]  E. Goretti,et al.  Heavy metal bioaccumulation in honey bee matrix, an indicator to assess the contamination level in terrestrial environments. , 2019, Environmental pollution.

[36]  Amin Mousavi Khaneghah,et al.  The concentration of potentially toxic elements (PTEs) in honey: A global systematic review and meta-analysis and risk assessment , 2019, Trends in Food Science & Technology.

[37]  S. Perveen,et al.  Pharmacognosy - Medicinal Plants , 2019 .

[38]  I. Mladenović-Ranisavljević,et al.  Concentrations of Heavy Metal Cations and a Health Risk Assessment of Sediments and River Surface Water: A Case Study from a Serbian Mine , 2019, Polish Journal of Environmental Studies.

[39]  L. Craker,et al.  Role of Medicinal and Aromatic Plants: Past, Present, and Future , 2019, Pharmacognosy - Medicinal Plants.

[40]  B. Suleiman,et al.  BIOSAFETY KNOWLEDGE, WASTE DISPOSAL PRACTICES AND IDENTIFICATION OF PARASITES IN BIOMEDICAL WASTES FROM HEALTHCARE ESTABLISHMENTS IN LAGOS AND ABUJA, NIGERIA , 2019 .

[41]  Qiuyan Lu,et al.  Potential exposure to metals and health risks of metal intake from Tieguanyin tea production in Anxi, China , 2018, Environmental Geochemistry and Health.

[42]  P. Whelton Sodium and Potassium Intake in US Adults , 2018, Circulation.

[43]  G. Łysiak,et al.  Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry , 2017, Journal of Functional Foods.

[44]  D. Puntarić,et al.  Pollen, Physicochemical, and Mineral Analysis of Croatian Acacia Honey Samples: Applicability for Identification of Botanical and Geographical Origin , 2017 .

[45]  Antonio F. Hernández,et al.  Determination of metalloid, metallic and mineral elements in herbal teas. Risk assessment for the consumers , 2017 .

[46]  C. Savii,et al.  Elemental Characterization of Romanian Crop Medicinal Plants by Neutron Activation Analysis , 2017, Journal of analytical methods in chemistry.

[47]  S. Khalid,et al.  Foliar heavy metal uptake, toxicity and detoxification in plants: A comparison of foliar and root metal uptake. , 2017, Journal of hazardous materials.

[48]  H. Sievers,et al.  Transition rates of selected metals determined in various types of teas (Camellia sinensis L. Kuntze) and herbal/fruit infusions. , 2017, Food chemistry.

[49]  M. Blades Handbook of Mineral Elements in Food , 2016 .

[50]  A. Bărbulescu,et al.  Taste of medicinal plants: A potential tool in predicting ethnopharmacological activities? , 2015, Journal of ethnopharmacology.

[51]  S. Hosseinzadeh,et al.  The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris , 2015 .

[52]  P. Pohl,et al.  Elemental composition of sugar and honey , 2015 .

[53]  D. Vélez,et al.  Other foods of plant origin , 2015 .

[54]  Ord,et al.  Exposure Assessment Tools by Routes - Ingestion , 2015 .

[55]  V. Ettler,et al.  The pH-dependent long-term stability of an amorphous manganese oxide in smelter-polluted soils: implication for chemical stabilization of metals and metalloids. , 2015, Journal of hazardous materials.

[56]  M. Gavrilescu,et al.  Emerging pollutants in the environment: present and future challenges in biomonitoring, ecological risks and bioremediation. , 2015, New biotechnology.

[57]  G. Dixon,et al.  Horticulture: Plants for People and Places, Volume 2 , 2014, Springer Netherlands.

[58]  Q. Ru,et al.  Risk assessment of heavy metals in honey consumed in Zhejiang province, southeastern China. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[59]  R. Street Heavy metals in medicinal plant products — An African perspective , 2012 .

[60]  D. Diaconu,et al.  Estimation of heavy metals in medicinal plants and their infusions , 2012 .

[61]  A. Peter,et al.  Lead traceability along soil-melliferous flora-bee family-apiary products chain. , 2012, Journal of environmental monitoring : JEM.

[62]  M. Vaher,et al.  Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia , 2011, Natural product research.

[63]  Soledad Cerutti,et al.  Determination of heavy metals for the quality control in Argentinian herbal medicines by ETAAS and ICP-OES. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[64]  S. Bogdanov,et al.  Minerals in honey: environmental, geographical and botanical aspects , 2007 .

[65]  R. Jiang,et al.  Cadmium uptake, translocation and tolerance in the hyperaccumulator Arabidopsis halleri. , 2006, The New phytologist.

[66]  平澤 緑 海外情報 欧州食品安全機関(EFSA:The European Food Safety Authority) , 2003 .

[67]  A. Zuckerman,et al.  IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , 1995, IARC monographs on the evaluation of carcinogenic risks to humans.

[68]  D. Barnes,et al.  Reference dose (RfD): description and use in health risk assessments. , 1988, Regulatory toxicology and pharmacology : RTP.

[69]  Division on Earth Risk Assessment in the Federal Government: Managing the Process , 1983 .

[70]  M. Zaynab,et al.  Health and environmental effects of heavy metals , 2022 .

[71]  A. Bărbulescu,et al.  MONITORING AND STATISTICAL ASSESSEMENT OF HEAVY METALS IN SOIL AND LEAVES OF Populus Nigra L , 2017 .

[72]  L. Craker,et al.  Medicinal and Aromatic Plants—Uses and Functions , 2014 .

[73]  A. Hosu,et al.  Determination of the floral origin of some Romanian honeys on the basis of physical and biochemical properties. , 2013, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[74]  L. Barbeș,et al.  Studies concerning heavy metals accumulation of Carduus nutans L. and Taraxacum officinale as potential soil bioindicator species , 2013 .

[75]  B. Kołodziej,et al.  Effect of traffic pollution on chemical composition of raw elderberry (Sambucus nigra L.). , 2012 .

[76]  Arsenic, metals, fibres, and dusts. , 2012, IARC monographs on the evaluation of carcinogenic risks to humans.

[77]  Christine L. Taylor,et al.  Sodium Intake Estimates for 2003–2006 and Description of Dietary Sources , 2010 .

[78]  U. Solimene,et al.  WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues , 2007 .

[79]  U. Epa Guidelines for carcinogen risk assessment , 1986 .

[80]  Intakes for Calcium , Phosphorus , Magnesium , Vitamin D , and Fluoride , 1974 .