Treatment of depression as part of end-of-life care

We present a case report of a severe treatment resistant major depressive episode in a patient with advanced cancer and limited life expectancy which resolved completely within 10 days of commencing combination therapy involving mirtazepine and paroxetine. Aggressive treatment of clinical depression even in the context of short life expectancy (that is, a short number of weeks) can dramatically reduce patient and family distress and improve quality of life.