Concise Total Synthesis of (+)-Disparlureand its trans-Isomer UsingAsymmetric Organocatalysis

The efficient enantioselective synthesis of (+)-disparlure and its trans-isomer is described. This approach involves tandem asymmetric organocatalytic α-aminoxylation―allylation of an aldehyde and olefin cross metathesis using Grubbs' catalyst as key steps.