Evidence for human T cell lymphoma-leukemia virus infection of family members of human T cell lymphoma-leukemia virus positive T cell leukemia-lymphoma patients

Sera of family members of patients from the United States, the Caribbean, and Japan, with human T cell lymphoma-leukemia virus (HTLV) associated T cell malignancies, possess HTLV-specific antibodies directed against internal structural components of HTLV, p24 and p19. The prevalence of antibodies to HTLV is greater in family members than in random healthy donors, which supports the infectious nature of HTLV and its association with particular aggressive T cell malignancies. Expression of HTLV p24 and p19 has also been observed in cultured T cells of some healthy relatives, and intact virus particles have been released from cells of one possibly pre-leukemic family member.

[1]  M. Reitz,et al.  The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group , 1982, Nature.

[2]  Y. Ito,et al.  Identification of HTLV p19 specific natural human antibodies by competition with monoclonal antibody. , 1982, Virology.

[3]  W. Blattner,et al.  The human type‐C retrovirus, HTLV, in blacks from the Caribbean region, and relationship to adult T‐cell leukemia/lymphoma , 1982, International journal of cancer.

[4]  M. Reitz,et al.  Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Y. Ohtsuki,et al.  Asymptomatic type C virus carriers in the family of an adult T-cell leukemia patient. , 1982, Gan.

[6]  M. Greaves,et al.  ADULT T-CELL LYMPHOMA-LEUKAEMIA IN BLACKS FROM THE WEST INDIES , 1982, The Lancet.

[7]  Y. Ito,et al.  Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Yoshida,et al.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Y. Ito,et al.  Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia. , 1982, Science.

[10]  M. Robert-Guroff,et al.  Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody , 1981, The Journal of experimental medicine.

[11]  J. Minna,et al.  Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virus , 1981, Nature.

[12]  M. Reitz,et al.  Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia , 1981, Nature.

[13]  P. Bunn,et al.  Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas , 1981, The Journal of experimental medicine.

[14]  R. Gallo,et al.  Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses , 1981, Journal of virology.

[15]  M. Reitz,et al.  Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[16]  John D. Minna,et al.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma , 1980, Proceedings of the National Academy of Sciences.

[17]  J. Mier,et al.  T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Yodoi,et al.  Adult T-cell leukemia: clinical and hematologic features of 16 cases. , 1977, Blood.

[19]  H. Towler,et al.  Adult T-cell leukemia : antigen in an ATL cell line and detection of antibodies to the antigen in human sera , 2022 .