THE EFFECTS OF A NEW β‐ADRENOCEPTOR BLOCKING COMPOUND, TOLAMOLOL, ON HAEMODYNAMICS AND MYOCARDIAL FUNCTION IN MAN

1 The effects of tolamolol on haemodynamics and myocardial contractility were investigated in two groups of six patients undergoing diagnostic cardiac catheterization. 2 The intravenous administration of tolamolol (0.15 mg/kg) produced a significant fall in heart rate from a control value (87 ± 7 to 62 ± 3 beats/min) 5 min after administration and a concomitant fall in cardiac output from 4.7 ± 0.9 to 3.5 ± 0.8 litres/minute. There was no significant change in systemic blood pressure, pulmonary artery blood pressure or stroke volume. 3 There was no change in left ventricular end diastolic pressure after tolamolol. There was a fall in the maximum rate of rise of the left ventricular pressure (LV dp/dtmax) and the derived index of the left ventricular contractile state (Vmax). 4 These results suggest that tolamolol has a predominantly negative chronotropic but also a lesser negative inotropic action on the heart.

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