Transcriptional control of the cell cycle.

Although a significant amount of evidence has demonstrated that there are intimate connections between transcriptional controls and cell cycle regulation, the precise mechanisms underlying these connections remain largely obscure. A number of recent advances have helped to define how critical cell cycle regulators, such as the retinoblastoma family of tumor suppressor proteins and the cyclin-dependent kinases, might function on a biochemical level and how such mechanisms of action have been conserved not only in the regulation of transcription by all three RNA polymerases but also across species lines. In addition, the use of in vivo techniques has begun to explain how the activity of the E2F transcription factor family is tied to the cell cycle dependent expression of target genes.

[1]  R. Müller,et al.  Transcriptional regulation during the mammalian cell cycle. , 1995, Trends in genetics : TIG.

[2]  K. Ozato,et al.  Displacement of sequence-specific transcription factors from mitotic chromatin , 1995, Cell.

[3]  T. Crook,et al.  HPV16 E7 oncoprotein deregulates B‐myb expression: correlation with targeting of p107/E2F complexes. , 1994, The EMBO journal.

[4]  S. Weintraub,et al.  Mechanism of active transcriptional repression by the retinoblastoma protein , 1995, Nature.

[5]  C. Peng,et al.  Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation , 1994, Molecular and cellular biology.

[6]  K Nasmyth,et al.  Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2. , 1996, Genes & development.

[7]  C. Y. Wang,et al.  Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. , 1993, Science.

[8]  T. Hunter,et al.  Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.

[9]  N. L. La Thangue,et al.  Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. , 1992, The EMBO journal.

[10]  P. Robbins,et al.  The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Andrew J. Bannister,et al.  The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[12]  R. Young,et al.  A kinase–cyclin pair in the RNA polymerase II holoenzyme , 1995, Nature.

[13]  F. C. Lucibello,et al.  Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. , 1995, The EMBO journal.

[14]  J. Lawrence,et al.  E2F-4, a new member of the E2F transcription factor family, interacts with p107. , 1994, Genes & development.

[15]  J. Nevins,et al.  Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. , 1994, Genes & development.

[16]  K. Yokoyama,et al.  The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator , 1994, Molecular and cellular biology.

[17]  Liang Zhu,et al.  Interaction of c‐Myc with the pRb‐related protein p107 results in inhibition of c‐Myc‐mediated transactivation. , 1994, The EMBO journal.

[18]  L. J. Veer,et al.  E2F-5, a new E2F family member that interacts with p130 in vivo , 1995, Molecular and cellular biology.

[19]  B. Dynlacht,et al.  Differential regulation of E2F transactivation by cyclin/cdk2 complexes. , 1994, Genes & development.

[20]  Jay W. Schneider,et al.  Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation , 1993, Cell.

[21]  C. Dang,et al.  Binding and suppression of the Myc transcriptional activation domain by p107. , 1994, Science.

[22]  N. Heintz,et al.  Protein-DNA interactions at the major and minor promoters of the divergently transcribed dhfr and rep3 genes during the Chinese hamster ovary cell cycle , 1996, Molecular and cellular biology.

[23]  R. Weinberg,et al.  E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[24]  E. Nigg,et al.  Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J. Nevins,et al.  The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. , 1992, Genes & development.

[26]  A. Iavarone,et al.  The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. , 1994, Genes & development.

[27]  G. Pfeifer,et al.  In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression , 1995, Molecular and cellular biology.

[28]  D. Riley,et al.  Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[29]  N. Dyson.  pRB, p107 and the regulation of the E2F transcription factor , 1994, Journal of Cell Science.

[30]  Lingyun Zhu,et al.  Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins , 1995, Molecular and cellular biology.

[31]  Wilhelm Krek,et al.  Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase , 1994, Cell.

[32]  Michael R. Green,et al.  Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2 , 1992, Nature.

[33]  L. Taylor,et al.  Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product , 1995, Nature.

[34]  M. Sporn,et al.  Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. C. Lucibello,et al.  Periodic cdc25C transcription is mediated by a novel cell cycle‐regulated repressor element (CDE). , 1995, The EMBO journal.

[36]  K. Nasmyth,et al.  Cell cycle regulated transcription in yeast. , 1994, Current opinion in cell biology.

[37]  W. Sellers,et al.  A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Livingston,et al.  Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. , 1995, Genes & development.

[39]  A. Rustgi,et al.  Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product , 1991, Nature.

[40]  D. Forbes,et al.  Mitotic repression of RNA polymerase III transcription in vitro mediated by phosphorylation of a TFIIIB component. , 1994, Science.

[41]  Sushovan Guha,et al.  The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest , 1994, Cell.

[42]  Wanjin Hong,et al.  A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor , 1995, Nature.

[43]  E. Lam,et al.  An E2F‐binding site mediates cell‐cycle regulated repression of mouse B‐myb transcription. , 1993, The EMBO journal.