The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

[1]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[2]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[3]  James M. Roberts,et al.  Hypertension in Pregnancy: Executive Summary , 2013 .

[4]  M. Schrappe,et al.  Therapy results in five ALL-BFM studies since 1970: implications of risk factors for prognosis. , 1987, Haematology and blood transfusion.

[5]  Hans Clevers,et al.  Modeling Development and Disease with Organoids , 2016, Cell.

[6]  A. Carter.  Faculty Opinions recommendation of Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[7]  Nhu Q Vu,et al.  Recent Advances and New Perspectives in Capillary Electrophoresis-Mass Spectrometry for Single Cell “Omics” , 2018, Molecules.

[8]  M. Klauber,et al.  Outcome from head injury related to patient's age. A longitudinal prospective study of adult and pediatric head injury. , 1988, Journal of Neurosurgery.

[9]  Rosalyn W. Sayaman,et al.  Tissue aging: the integration of collective and variant responses of cells to entropic forces over time. , 2018, Current opinion in cell biology.

[10]  Roland Eils,et al.  The Human Cell Atlas White Paper , 2018, 1810.05192.

[11]  M. Relling,et al.  Human cytochrome P450 maximal activities in pediatric versus adult liver. , 2000, Drug metabolism and disposition: the biological fate of chemicals.

[12]  M. Caputo,et al.  Age-Dependent and Hypoxia-Related Differences in Myocardial Protection During Pediatric Open Heart Surgery , 2001, Circulation.

[13]  A. Shilatifard,et al.  Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis , 2019, American journal of respiratory and critical care medicine.

[14]  P. Wales,et al.  Establishing norms for intestinal length in children. , 2009, Journal of pediatric surgery.

[15]  R. Xavier,et al.  Mechanisms of Pediatric Inflammatory Bowel Disease. , 2016, Annual review of immunology.

[16]  C. Greene,et al.  Parameter tuning is a key part of dimensionality reduction via deep variational autoencoders for single cell RNA transcriptomics , 2018, PSB.

[17]  Xiaojing Ma.  Faculty Opinions recommendation of Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[18]  James T. Webber,et al.  Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris , 2018, Nature.

[19]  T. Stephenson.  How children's responses to drugs differ from adults. , 2005, British journal of clinical pharmacology.

[20]  Kashish Chetal,et al.  The Human Cell Atlas bone marrow single-cell interactive web portal , 2018, Experimental hematology.

[21]  Enrico Grisan,et al.  Early origins of adult disease: low birth weight and vascular remodeling. , 2014, Atherosclerosis.

[22]  Alan Ruttenberg,et al.  A strategy for building neuroanatomy ontologies , 2012, Bioinform..

[23]  M. Carrington,et al.  Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. , 2010, The Journal of clinical investigation.

[24]  I. Douglas,et al.  Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance? , 2015, Immunology.

[25]  James Hicks,et al.  Unravelling biology and shifting paradigms in cancer with single-cell sequencing , 2017, Nature Reviews Cancer.

[26]  Bin Chen,et al.  Selecting precise reference normal tissue samples for cancer research using a deep learning approach , 2019, BMC Medical Genomics.

[27]  J. Seidman,et al.  Single-Cell Resolution of Temporal Gene Expression during Heart Development. , 2016, Developmental cell.

[28]  A. Stevens,et al.  Human growth is associated with distinct patterns of gene expression in evolutionarily conserved networks , 2013, BMC Genomics.

[29]  D. Cho,et al.  Single cell transcriptome analysis of muscle satellite cells reveals widespread transcriptional heterogeneity. , 2017, Gene.

[30]  S. Teichmann,et al.  Exponential scaling of single-cell RNA-seq in the past decade , 2017, Nature Protocols.

[31]  R. Kauffman,et al.  The Need for Pediatric Drug Development. , 2018, The Journal of pediatrics.

[32]  P. Kharchenko,et al.  Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain , 2017, Nature Biotechnology.

[33]  E. Szigethy,et al.  Inflammatory bowel disease. , 2011, Pediatric clinics of North America.

[34]  Allon M. Klein,et al.  A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte , 2018, Nature.

[35]  S. Gabriel,et al.  De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly , 2012, Nature Genetics.

[36]  B. Dallapiccola,et al.  The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood , 2014, Pediatric Research.

[37]  Lu Wen,et al.  Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing. , 2018, Cell reports.

[38]  Xin Zhou,et al.  Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors , 2018, Nature.

[39]  D. Stram,et al.  Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: a Children's Cancer Group study. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  N. Slavov,et al.  SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation , 2017, Genome Biology.

[41]  Keith Marsolo,et al.  The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system , 2019, Genetics in Medicine.

[42]  Peter J. Park,et al.  Somatic mutation in single human neurons tracks developmental and transcriptional history , 2015, Science.

[43]  A. McMichael,et al.  Evolution of the immune system in humans from infancy to old age , 2015, Proceedings of the Royal Society B: Biological Sciences.

[44]  Kerstin B. Meyer,et al.  Single-cell reconstruction of the early maternal–fetal interface in humans , 2018, Nature.

[45]  Elizabeth A. Calle,et al.  Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. , 2014, Cell stem cell.

[46]  S. Tapscott,et al.  Single‐cell RNA sequencing in facioscapulohumeral muscular dystrophy disease etiology and development , 2018, Human molecular genetics.

[47]  Principal Investigators,et al.  Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris , 2018 .

[48]  J. Brandner,et al.  The skin: an indispensable barrier , 2008, Experimental dermatology.

[49]  Richard H Scheuermann,et al.  Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type , 2017, Nature Neuroscience.

[50]  Lars E. Borm,et al.  Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells , 2016, Cell.

[51]  Andrew C. Adey,et al.  Single-Cell Transcriptional Profiling of a Multicellular Organism , 2017 .

[52]  A. Brazma,et al.  Gene expression data analysis. , 2001, FEBS letters.

[53]  P. Rigollet,et al.  Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming , 2019, Cell.

[54]  Adele M Doyle,et al.  Fixed single-cell transcriptomic characterization of human radial glial diversity , 2015, Nature Methods.

[55]  Aviv Regev,et al.  A revised airway epithelial hierarchy includes CFTR-expressing ionocytes , 2018, Nature.

[56]  A. Briend,et al.  The Immune System in Children with Malnutrition—A Systematic Review , 2014, PloS one.

[57]  Fabian J Theis,et al.  Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics , 2018, Science.

[58]  J. Bezerra,et al.  Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes , 2015, Nature Reviews Gastroenterology &Hepatology.

[59]  M. Toth,et al.  Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification , 2016, The Journal of Neuroscience.

[60]  O. Stegle,et al.  Single-cell epigenomics: Recording the past and predicting the future , 2017, Science.

[61]  Burkhard Tümmler,et al.  Faculty Opinions recommendation of A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[62]  J. Marriott,et al.  Paediatric pharmacokinetics: key considerations. , 2015, British journal of clinical pharmacology.

[63]  Yufeng Shen,et al.  Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands , 2017, Nature Genetics.

[64]  F. Reimann,et al.  Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity , 2017, Mucosal Immunology.

[65]  B. Wilkins,et al.  Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts , 2018, Genes & development.

[66]  Y. Belkaid,et al.  Role of the Microbiota in Immunity and Inflammation , 2014, Cell.

[67]  J. C. Love,et al.  Seq-Well: A Portable, Low-Cost Platform for High-Throughput Single-Cell RNA-Seq of Low-Input Samples , 2017 .

[68]  M. Periasamy,et al.  The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy , 2015, Biological reviews of the Cambridge Philosophical Society.

[69]  Fabian J Theis,et al.  A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease , 2019, bioRxiv.

[70]  T. Mikkelsen,et al.  Genome-scale DNA methylation maps of pluripotent and differentiated cells , 2008, Nature.

[71]  J. Clemente,et al.  Human gut microbiome viewed across age and geography , 2012, Nature.

[72]  B. Chumpitazi,et al.  Pediatric gastrointestinal motility disorders: challenges and a clinical update. , 2008, Gastroenterology & hepatology.

[73]  Nikolai Slavov,et al.  Transformative Opportunities for Single-Cell Proteomics. , 2018, Journal of proteome research.

[74]  Fred H. Gage,et al.  Neural Stem Cells: Generating and Regenerating the Brain , 2013, Neuron.

[75]  E. Tsigas,et al.  Preeclampsia and future cardiovascular disease in women: How good are the data and how can we manage our patients? , 2015, Seminars in perinatology.

[76]  A. Lindblad,et al.  Studies of Pediatric Liver Transplantation: 2002 update. An overview of demographics, indications, timing, and immunosuppressive practices in pediatric liver transplantation in the United States and Canada , 2004, Pediatric transplantation.

[77]  Jessica C. Mar,et al.  Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development , 2015, PLoS genetics.

[78]  P. Rigollet,et al.  Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming , 2017, bioRxiv.

[79]  Sarah A. Teichmann,et al.  Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors , 2018, Science.

[80]  M. van der Burg,et al.  Age‐matched Reference Values for B‐lymphocyte Subpopulations and CVID Classifications in Children , 2011, Scandinavian journal of immunology.

[81]  John F. Bertram,et al.  Human nephron number: implications for health and disease , 2011, Pediatric Nephrology.

[82]  Nicole C El-Ali,et al.  Single-nucleus RNA-seq of differentiating human myoblasts reveals the extent of fate heterogeneity , 2016, Nucleic acids research.

[83]  Aviv Regev,et al.  Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis , 2018 .

[84]  J. Ramos,et al.  Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults , 2011, Pharmaceutics.

[85]  J. C. Love,et al.  Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput , 2017, Nature Methods.

[86]  C. Walsh,et al.  Building a lineage from single cells: genetic techniques for cell lineage tracking , 2017, Nature Reviews Genetics.

[87]  S. Kaste,et al.  Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor , 2017, Oncotarget.

[88]  Yuanchao Zhang,et al.  Scedar: A scalable Python package for single-cell RNA-seq exploratory data analysis , 2018, bioRxiv.

[89]  R Mastrangelo,et al.  Report and recommendations of the Rome workshop concerning poor-prognosis acute lymphoblastic leukemia in children: biologic bases for staging, stratification, and treatment. , 1986, Medical and pediatric oncology.

[90]  B. Malissen,et al.  Pax 7-expressing satellite cells are indispensable for adult skeletal muscle regeneration , 2011 .

[91]  Michael P. Morrissey,et al.  Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. , 2016, JAMA neurology.

[92]  S. Quake,et al.  A survey of human brain transcriptome diversity at the single cell level , 2015, Proceedings of the National Academy of Sciences.

[93]  Suzanne Reuter,et al.  Respiratory distress in the newborn. , 2014, Pediatrics in review.

[94]  Jie Qiao,et al.  A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex , 2018, Nature.

[95]  Hong Wu,et al.  Notch Signaling, Brain Development, and Human Disease , 2005, Pediatric Research.

[96]  J. Mikes,et al.  Stereotypic Immune System Development in Newborn Children , 2018, Cell.

[97]  M. Davenport,et al.  Biliary atresia and other cholestatic childhood diseases: Advances and future challenges. , 2016, Journal of hepatology.

[98]  D. Tanyingoh,et al.  Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases , 2017, The American Journal of Gastroenterology.

[99]  Fabian J Theis,et al.  SCANPY: large-scale single-cell gene expression data analysis , 2018, Genome Biology.

[100]  Gary D Bader,et al.  Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations , 2018, Nature Communications.

[101]  C. Ponting,et al.  Single-Cell Multiomics: Multiple Measurements from Single Cells , 2017, Trends in genetics : TIG.

[102]  R A Etzel,et al.  Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. , 2000, Environmental health perspectives.

[103]  Bertrand Z. Yeung,et al.  Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics , 2018, Genome Biology.

[104]  Allon M. Klein,et al.  Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells , 2015, Cell.

[105]  S. Vermeire,et al.  Differences between adults and children: genetics and beyond , 2015, Expert review of gastroenterology & hepatology.

[106]  M. Kogevinas,et al.  The exposome in practice: Design of the EXPOsOMICS project , 2017, International journal of hygiene and environmental health.

[107]  Gouri Nanjangud,et al.  Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples , 2017, Nature Medicine.

[108]  O. Levy,et al.  Immune response to vaccine adjuvants during the first year of life. , 2013, Vaccine.

[109]  J. Eriksson,et al.  Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study , 2017, American journal of obstetrics and gynecology.

[110]  E. Morrisey,et al.  Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor , 2018, Nature.

[111]  J. Wells,et al.  Chronic disease outcomes after severe acute malnutrition in Malawian children (ChroSAM): a cohort study , 2016, The Lancet. Global health.

[112]  Fabian J Theis,et al.  The Human Cell Atlas , 2017, bioRxiv.

[113]  Howard Y. Chang,et al.  Single-cell chromatin accessibility reveals principles of regulatory variation , 2015, Nature.

[114]  H. Watz,et al.  Chronic obstructive pulmonary disease , 2017, The Lancet.

[115]  Paul D Piehowski,et al.  New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells. , 2019, The Analyst.

[116]  A. Shennan,et al.  Faculty Opinions recommendation of Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. , 2015 .

[117]  Evan Z. Macosko,et al.  Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets , 2015, Cell.

[118]  A. Cvejic,et al.  Single-cell biology: resolving biological complexity, one cell at a time , 2018, Development.

[119]  C. Pui,et al.  Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[120]  C. Schevon,et al.  Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy , 2018, Annals of neurology.

[121]  Christoph Lepper,et al.  An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration , 2011, Development.

[122]  K. V. van Stralen,et al.  Epidemiology of chronic kidney disease in children , 2011, Pediatric Nephrology.

[123]  D. Barker,et al.  The Developmental Origins of Adult Disease , 2004, Journal of the American College of Nutrition.

[124]  Gordon C.S. Smith.  First-trimester determination of complications of late pregnancy. , 2010, JAMA.

[125]  H. Wong,et al.  Pediatric Sepsis - Part I: "Children are not small adults!" , 2011, The open inflammation journal.

[126]  R. Satija,et al.  Integrative single-cell analysis , 2019, Nature Reviews Genetics.

[127]  A. Shennan,et al.  Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. , 2015, Obstetrics and gynecology.

[128]  B. Hallström,et al.  Expression of Human Skin-Specific Genes Defined by Transcriptomics and Antibody-Based Profiling , 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[129]  Michael J. T. Stubbington,et al.  Single-cell transcriptomics to explore the immune system in health and disease , 2017, Science.

[130]  Marc S. Williams,et al.  Key Implications of Data Sharing in Pediatric Genomics , 2017, JAMA pediatrics.

[131]  Lior Pachter,et al.  Highly Multiplexed Single-Cell RNA-seq for Defining Cell Population and Transcriptional Spaces , 2018, bioRxiv.

[132]  L. Steinmetz,et al.  Human haematopoietic stem cell lineage commitment is a continuous process , 2017, Nature Cell Biology.

[133]  S. Yusuf,et al.  Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses. , 2008, American heart journal.

[134]  The Gene Ontology Consortium,et al.  Expansion of the Gene Ontology knowledgebase and resources , 2016, Nucleic Acids Res..

[135]  G. Burton,et al.  The placenta: a multifaceted, transient organ , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

[136]  E. Loftus.  Mortality in inflammatory bowel disease: peril and promise. , 2003, Gastroenterology.

[137]  Alexander D. Diehl,et al.  Logical Development of the Cell Ontology , 2011, BMC Bioinformatics.

[138]  Robert O Wright,et al.  Environment, susceptibility windows, development, and child health , 2017, Current opinion in pediatrics.

[139]  D. Hackam,et al.  Necrotizing enterocolitis: new insights into pathogenesis and mechanisms , 2016, Nature Reviews Gastroenterology &Hepatology.

[140]  J. Botkin.  Ethical issues in pediatric genetic testing and screening , 2016, Current opinion in pediatrics.

[141]  N. Neff,et al.  Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq , 2014, Nature.

[142]  J. Eberwine,et al.  Amplified RNA synthesized from limited quantities of heterogeneous cDNA. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[143]  B. Huppertz.  Placental Origins of Preeclampsia: Challenging the Current Hypothesis , 2008, Hypertension.

[144]  Takeshi Matsui,et al.  Dissecting the formation, structure and barrier function of the stratum corneum. , 2015, International immunology.

[145]  R. Satija,et al.  Single-cell RNA sequencing to explore immune cell heterogeneity , 2017, Nature Reviews Immunology.

[146]  G. von Heijne,et al.  Tissue-based map of the human proteome , 2015, Science.

[147]  P. Gluckman,et al.  Early developmental conditioning of later health and disease: physiology or pathophysiology? , 2014, Physiological reviews.

[148]  J. Eberwine,et al.  Analysis of gene expression in single live neurons. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[149]  A. Tanay,et al.  Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq , 2018, Cell.

[150]  Jianming Xu,et al.  Local lung hypoxia determines epithelial fate decisions during alveolar regeneration , 2017, Nature Cell Biology.

[151]  John B. Furness,et al.  The enteric nervous system and neurogastroenterology , 2012, Nature Reviews Gastroenterology &Hepatology.

[152]  Jason R. Myers,et al.  Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[153]  Scott M. Palmer,et al.  LungMAP: The Molecular Atlas of Lung Development Program , 2017, American journal of physiology. Lung cellular and molecular physiology.

[154]  Christoph Lepper,et al.  An absolute requirement for Pax 7-positive satellite cells in acute injury-induced skeletal muscle regeneration , 2022 .

[155]  Srinjan Basu,et al.  Calculation of 3D genome structures for comparison of chromosome conformation capture experiments with microscopy: An evaluation of single-cell Hi-C protocols , 2018, Nucleus.

[156]  B. Stripp,et al.  Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. , 2016, JCI insight.

[157]  Peiyong Jiang,et al.  Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics , 2017, Proceedings of the National Academy of Sciences.

[158]  A. Ransick,et al.  Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. , 2018, Journal of the American Society of Nephrology : JASN.

[159]  Christopher S. Poultney,et al.  Rates, Distribution, and Implications of Post-zygotic Mosaic Mutations in Autism Spectrum Disorder , 2017, Nature Neuroscience.

[160]  P. Rigollet,et al.  Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming , 2019, Cell.

[161]  Xin Zhao,et al.  Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells. , 2017, Blood.

[162]  G. Wagner,et al.  Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. , 2017, Genome research.

[163]  Cheng Cheng,et al.  Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia , 2016, EBioMedicine.

[164]  Y. Ben-Shlomo,et al.  A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives , 2002 .

[165]  H. Trachtman,et al.  Focal segmental glomerulosclerosis and chronic kidney disease in pediatric patients. , 2011, Advances in chronic kidney disease.

[166]  D. Postma,et al.  Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. , 2016, The New England journal of medicine.

[167]  Xiang-Dong Fu,et al.  ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle , 2005, Cell.

[168]  Z. Bar-Joseph,et al.  Using neural networks for reducing the dimensions of single-cell RNA-Seq data , 2017, Nucleic acids research.

[169]  Javier DeFelipe,et al.  Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18. , 2006, Progress in brain research.

[170]  Michael Inouye,et al.  An exposome perspective: Early‐life events and immune development in a changing world , 2017, The Journal of allergy and clinical immunology.

[171]  D. Andropoulos.  Effect of Anesthesia on the Developing Brain: Infant and Fetus , 2017, Fetal Diagnosis and Therapy.

[172]  Amélie Collins,et al.  Why are preterm newborns at increased risk of infection? , 2018, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[173]  M. Kalmanti,et al.  Comparative study of stemness characteristics of mesenchymal cells from bone marrow of children and adults. , 2010, Cytotherapy.

[174]  Ying Guo,et al.  Single Cell Multi-Omics Technology: Methodology and Application , 2018, Front. Cell Dev. Biol..

[175]  Bonnie Berger,et al.  Generalizable and Scalable Visualization of Single-Cell Data Using Neural Networks. , 2018, Cell systems.

[176]  Lu Wen,et al.  Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing , 2018, Nature Cell Biology.

[177]  C. Thompson,et al.  The Children's Health Exposure Analysis Resource: enabling research into the environmental influences on children's health outcomes , 2017, Current opinion in pediatrics.

[178]  Christopher A Walsh,et al.  Somatic mosaicism and neurodevelopmental disease , 2018, Nature Neuroscience.

[179]  Yarden Katz,et al.  A single-cell survey of the small intestinal epithelium , 2017, Nature.

[180]  N. Hacohen,et al.  Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors , 2017, Science.

[181]  W. Hay,et al.  The Fragile State of the National Institutes of Health Pediatric Research Portfolio, 1992-2015: Doing More With Less? , 2018, JAMA pediatrics.

[182]  Fred H. Gage,et al.  Generation of neuronal variability and complexity , 2006, Nature.

[183]  G. Bejerano,et al.  Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly , 2017, Brain : a journal of neurology.

[184]  G. Sanguinetti,et al.  scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells , 2018, Nature Communications.

[185]  S. Harpavat,et al.  Patients With Biliary Atresia Have Elevated Direct/Conjugated Bilirubin Levels Shortly After Birth , 2011, Pediatrics.

[186]  B. Malissen,et al.  Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration , 2011, Development.

[187]  H. Clevers,et al.  Defining Adult Stem Cells by Function, not by Phenotype. , 2018, Annual review of biochemistry.

[188]  Y. Xing,et al.  The Expanding Landscape of Alternative Splicing Variation in Human Populations , 2018, American journal of human genetics.

[189]  S. Saeed,et al.  Inflammatory Bowel Disease in Children and Adolescents. , 2021, Advances in pediatrics.

[190]  Shaun S Kumar,et al.  State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development , 2018, Clinical Pharmacokinetics.

[191]  J. Marioni,et al.  How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology. , 2017, Annual review of cell and developmental biology.

[192]  H. Schulz,et al.  CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia. , 2016, Circulation research.

[193]  Alex A. Pollen,et al.  Molecular Identity of Human Outer Radial Glia during Cortical Development , 2015, Cell.

[194]  J. Eriksson,et al.  Early growth and coronary heart disease in later life: longitudinal study , 2001, BMJ : British Medical Journal.

[195]  S. Karavasiliadou,et al.  The factors contributing to the risk of sudden infant death syndrome. , 2011, Hippokratia.

[196]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[197]  A. Fanaroff.  Birth Prevalence of Congenital Heart Disease Worldwide: A Systematic Review and Meta-Analysis , 2012 .

[198]  L. Kubzansky,et al.  Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health , 2018, Neuroscience & Biobehavioral Reviews.

[199]  T E Starzl,et al.  Liver transplantation. , 1967, Bulletin de la Societe internationale de chirurgie.

[200]  Mikael Benson,et al.  Single-cell analyses to tailor treatments , 2017, Science Translational Medicine.

[201]  S. Teichmann,et al.  Mapping human development at single-cell resolution , 2018, Development.

[202]  P. Sly,et al.  Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment , 2012, Nature Medicine.

[203]  Tracy T Batchelor,et al.  Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq , 2018, Science.

[204]  W. Haining,et al.  Normalizing the environment recapitulates adult human immune traits in laboratory mice , 2016, Nature.

[205]  N. Iscove,et al.  Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies , 1990 .

[206]  M. Elowitz,et al.  Challenges and emerging directions in single-cell analysis , 2017, Genome Biology.

[207]  C. Lynch,et al.  Improved survival of follicular lymphoma patients in the surveillance, epidemiology, and end-results (SEER) program , 2004 .

[208]  S. Mazmanian,et al.  Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. , 2017, Immunity.

[209]  E. V. van Donselaar,et al.  Single organelle dynamics linked to 3D structure by correlative live‐cell imaging and 3D electron microscopy , 2018, Traffic.

[210]  R. Pieters,et al.  Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study. , 2010, Blood.

[211]  Cole Trapnell,et al.  Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation. , 2018, Trends in genetics : TIG.

[212]  The Gene Ontology Consortium.  Expansion of the Gene Ontology knowledgebase and resources , 2016, Nucleic Acids Res..

[213]  A. Nuyt,et al.  Preeclampsia: effect on newborn blood pressure in the 3 days following preterm birth: a cohort study , 2014, Journal of Human Hypertension.

[214]  Michael J. T. Stubbington,et al.  The Human Cell Atlas: from vision to reality , 2017, Nature.

[215]  W. Hay,et al.  The uncertain fate of the National Institutes of Health (NIH) pediatric research portfolio , 2018, Pediatric Research.

[216]  High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations. , 2019, Molecular cell.

[217]  Trygve E Bakken,et al.  Cell type discovery using single-cell transcriptomics: implications for ontological representation , 2018, Human molecular genetics.

[218]  Ravi S. Misra,et al.  Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development , 2017, Thorax.

[219]  Dong Seok Kim,et al.  Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. , 2017, American journal of human genetics.

[220]  E. Ravussin,et al.  Skeletal muscle metabolism is a major determinant of resting energy expenditure. , 1990, The Journal of clinical investigation.

[221]  B. Emery,et al.  Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System. , 2015, Cold Spring Harbor perspectives in biology.

[222]  J. Roos‐Hesselink,et al.  Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. , 2011, Journal of the American College of Cardiology.

[223]  Cole Trapnell,et al.  Defining cell types and states with single-cell genomics , 2015, Genome research.

[224]  Z. Bar-Joseph,et al.  Reconstructing differentiation networks and their regulation from time series single-cell expression data , 2018, Genome research.

[225]  F. Reimann,et al.  Gut chemosensing mechanisms. , 2015, The Journal of clinical investigation.

[226]  Kevin R. Moon,et al.  Recovering Gene Interactions from Single-Cell Data Using Data Diffusion , 2018, Cell.

[227]  S. Hilsenbeck,et al.  Pediatric Data Sharing in Genomic Research: Attitudes and Preferences of Parents , 2014, Pediatrics.

[228]  Alex A. Pollen,et al.  Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex , 2017, Science.

[229]  David Osumi-Sutherland.  Cell ontology in an age of data-driven cell classification , 2017, BMC Bioinformatics.

[230]  Derek W Wright,et al.  Gateways to the FANTOM5 promoter level mammalian expression atlas , 2015, Genome Biology.

[231]  M. Merad,et al.  High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue , 2018, Mucosal Immunology.

[232]  D. Muzny,et al.  Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse. , 2016, Cancer research.

[233]  S. Hearps,et al.  Age-dependent differences in the impact of paediatric traumatic brain injury on executive functions: A prospective study using susceptibility-weighted imaging , 2019, Neuropsychologia.

[234]  C. Nievergelt,et al.  Histopathology of pediatric nonalcoholic fatty liver disease , 2005, Hepatology.

[235]  P. Bossuyt,et al.  Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood , 2012, Diabetes.

[236]  Elizabeth J. Robertson,et al.  Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy , 2016, Nature Communications.

[237]  N. Martell Claros.  [Gestational hypertension]. , 2017, Hipertension y riesgo vascular.