Overexpression of survivin and cyclin D1 in CHO cells confers apoptosis resistance and enhances growth in serum-free suspension culture

[1]  G. Lee,et al.  Effect of Bcl‐xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient‐deprived condition , 2009, Biotechnology and bioengineering.

[2]  Vasiliki Ifandi,et al.  Regulation of Cell Proliferation and Apoptosis in CHO‐K1 Cells by the Coexpression of c‐Myc and Bcl‐2 , 2008, Biotechnology progress.

[3]  S. Fukuda,et al.  Survivin, a cancer target with an emerging role in normal adult tissues , 2006, Molecular Cancer Therapeutics.

[4]  F. Falciani,et al.  Over-expression of hTERT in CHO K1 results in decreased apoptosis and reduced serum dependency. , 2006, Journal of biotechnology.

[5]  Chenguang Wang,et al.  Minireview: Cyclin D1: normal and abnormal functions. , 2004, Endocrinology.

[6]  G. Lee,et al.  Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line. , 2003, Biotechnology and Bioengineering.

[7]  Martin Fussenegger,et al.  Metabolic engineering II. Eukaryotic systems. , 2002, Biotechnology and bioengineering.

[8]  Tony Hunter,et al.  Structural basis for phosphoserine-proline recognition by group IV WW domains , 2000, Nature Structural Biology.

[9]  J. Noel,et al.  Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement , 2000, Nature Structural Biology.

[10]  A. Fraser,et al.  Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis , 1999, Current Biology.

[11]  J C Reed,et al.  IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. , 1998, Cancer research.

[12]  G. Lee,et al.  Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells. , 2009, Journal of biotechnology.

[13]  D. Altieri.  Survivin, cancer networks and pathway-directed drug discovery , 2008, Nature Reviews Cancer.

[14]  T. So,et al.  The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes , 2007, Nature Immunology.