Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events 1

A fundamental event in the inflammatory response is recruitment of blood leukocytes to a site of injury or infection, often resulting in tissue dysfunction and damage. The steps in this recruitment process are leukocyte adhesion to the endothelial lining of the vessel wall, diapedesis, or

[1]  W. Muller Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. , 2003, Trends in immunology.

[2]  V. Papadopoulos,et al.  Molecular cloning, chromosomal localization of human peripheral‐type benzodiazepine receptor‐ and protein kinase A regulatory subunit type 1A (PRKAR1A)‐associated protein PAP7 and studies in PRKAR1A mutant cells and tissues , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  A. Mócsai,et al.  G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. , 2003, Blood.

[4]  S. Bourgoin,et al.  Chemotactic Factor-Induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils. II. Effects of LFM-A13, a Specific Btk Inhibitor1 , 2003, The Journal of Immunology.

[5]  C. Smith,et al.  Unique structural features that influence neutrophil emigration into the lung. , 2003, Physiological reviews.

[6]  D. Staunton,et al.  Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement , 2003, The Journal of Immunology.

[7]  F. Sinigaglia,et al.  Chemokine receptors in inflammation: an overview. , 2003, Journal of immunological methods.

[8]  H. Chen,et al.  Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium. , 2002, Blood.

[9]  K. Zen,et al.  CD11b/CD18-Dependent Interactions of Neutrophils with Intestinal Epithelium Are Mediated by Fucosylated Proteoglycans1 , 2002, The Journal of Immunology.

[10]  B. Heit,et al.  An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients , 2002, The Journal of cell biology.

[11]  M. Aurrand-Lions,et al.  Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. , 2002, Blood.

[12]  K. Preissner,et al.  The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1 , 2002, The Journal of experimental medicine.

[13]  B. Levi,et al.  Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration1 , 2002, The Journal of Immunology.

[14]  Paul Herzmark,et al.  Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils , 2002, Nature Cell Biology.

[15]  P. Naccache,et al.  Chemotactic Factor-induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils , 2002, The Journal of Biological Chemistry.

[16]  T. K. van den Berg,et al.  Signal-Regulatory Protein α-CD47 Interactions Are Required for the Transmigration of Monocytes Across Cerebral Endothelium1 , 2002, The Journal of Immunology.

[17]  A. Mócsai,et al.  Syk is required for integrin signaling in neutrophils. , 2002, Immunity.

[18]  Asma Nusrat,et al.  Leukocyte transendothelial migration: a junctional affair. , 2002, Seminars in immunology.

[19]  P. Hawkins,et al.  Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. , 2002, Current opinion in cell biology.

[20]  J. Mizgerd Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs. , 2002, Seminars in immunology.

[21]  O. Weiner,et al.  Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. , 2002, Current opinion in cell biology.

[22]  K. Zen,et al.  Signal Regulatory Protein (SIRPα), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration* , 2002, The Journal of Biological Chemistry.

[23]  A. Zernecke,et al.  JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes , 2002, Nature Immunology.

[24]  F. Luscinskas,et al.  Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow. , 2001, The American journal of pathology.

[25]  J. Madara,et al.  The Role of CD47 in Neutrophil Transmigration , 2001, The Journal of Biological Chemistry.

[26]  R. Alon,et al.  Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines , 2001, Nature Immunology.

[27]  W. Muller Migration of Leukocytes across Endothelial Junctions: Some Concepts and Controversies , 2001, Microcirculation.

[28]  F. Luscinskas,et al.  Wall shear stress: the missing step for T cell transmigration? , 2001, Nature Immunology.

[29]  S. Colgan,et al.  Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration. , 2001, Blood.

[30]  P. Ricciardi-Castagnoli,et al.  Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria , 2001, Nature Immunology.

[31]  E. Brown,et al.  Integrin-associated protein (CD47) and its ligands. , 2001, Trends in cell biology.

[32]  B. Cambien,et al.  Signal transduction involved in MCP-1-mediated monocytic transendothelial migration. , 2001, Blood.

[33]  S. Walsh,et al.  Human junction adhesion molecule regulates tight junction resealing in epithelia. , 2000, Journal of cell science.

[34]  M. Aurrand-Lions,et al.  The parting of the endothelium: miracle, or simply a junctional affair? , 2000, Journal of cell science.

[35]  Dianqing Wu,et al.  Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction , 2000 .

[36]  A. Ullrich,et al.  Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. , 1999, Blood.

[37]  A. Mócsai,et al.  Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. , 1999, Journal of immunology.

[38]  E. Roos,et al.  ZAP-70 Tyrosine Kinase Is Required for LFA-1–dependent T Cell Migration , 1998, The Journal of cell biology.

[39]  E. Dejana,et al.  Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration , 1998, The Journal of cell biology.

[40]  C. Lowell,et al.  Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  H. Dvorak,et al.  Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP , 1998, The Journal of experimental medicine.

[42]  C. Parkos Molecular events in neutrophil transepithelial migration , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[43]  E. Butcher,et al.  Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration , 1997, European journal of immunology.

[44]  M. Lampugnani,et al.  Interendothelial junctions: structure, signalling and functional roles. , 1997, Current opinion in cell biology.

[45]  M. Huang,et al.  Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. , 1997, Journal of immunology.

[46]  Eric J. Brown,et al.  Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice , 1996, Science.

[47]  M. Diamond,et al.  Expression and Polarization of Intercellular Adhesion Molecule-1 on Human Intestinal Epithelia: Consequences for CD11b/CD18-Mediated Interactions with Neutrophils , 1996, Molecular medicine.

[48]  Welch,et al.  Nonreceptor Protein-Tyrosine Kinases in Neutrophil Activation , 1996, Methods.

[49]  C. Lowell,et al.  Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions , 1996, The Journal of cell biology.

[50]  S. Colgan,et al.  CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia , 1996, The Journal of cell biology.

[51]  G. Bokoch,et al.  G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes (*) , 1995, The Journal of Biological Chemistry.

[52]  J. Gamble,et al.  Transendothelial migration of neutrophils involves integrin-associated protein (CD47). , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[53]  B. Geiger,et al.  The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha- catenin with vascular endothelial cadherin (VE-cadherin) , 1995, The Journal of cell biology.

[54]  C. Laudanna,et al.  Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils , 1994, The Journal of cell biology.

[55]  T. Springer Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm , 1994, Cell.

[56]  David E. Clapham,et al.  New roles for G-protein (βγ-dimers in transmembrane signalling , 1993, Nature.

[57]  B. Cronstein,et al.  Chemoattraction of neutrophils by substance P and transforming growth factor-beta 1 is inadequately explained by current models of lipid remodeling. , 1993, Journal of immunology.

[58]  C. Parkos,et al.  Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways , 1992, The Journal of cell biology.

[59]  M. Arnaout,et al.  Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. , 1991, The Journal of clinical investigation.

[60]  R. Rothlein,et al.  Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. , 1990, Science.

[61]  E. Chi,et al.  Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. , 1989, The Journal of clinical investigation.

[62]  A. Ullrich,et al.  Signal regulation by family conspiracy , 2001, Cellular and Molecular Life Sciences CMLS.

[63]  F. Luscinskas,et al.  Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium , 2001 .

[64]  S I Simon,et al.  Analysis of tight junctions during neutrophil transendothelial migration. , 2000, Journal of cell science.

[65]  P. Newman Switched at birth: a new family for PECAM-1. , 1999, The Journal of clinical investigation.