Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease

Parkinson’s disease bursts of oscillatory synchronization in the beta band are associated with motor impairment. Khawaldeh et al. provide clues to the underlying mechanisms by showing that beta bursts restrict the capacity of the basal ganglia system to encode physiologically relevant information about intended actions.

[1]  R. Vaidyanathan,et al.  Movement decoding using neural synchronization and inter-hemispheric connectivity from deep brain local field potentials , 2015, Journal of neural engineering.

[2]  Tipu Z. Aziz,et al.  Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson’s disease , 2016, Clinical Neurophysiology.

[3]  Nir Friedman,et al.  Bayesian Network Classifiers , 1997, Machine Learning.

[4]  J. Dostrovsky,et al.  Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity , 2002, The Journal of Neuroscience.

[5]  Mohammad H. Mahoor,et al.  A hierarchical structure for human behavior classification using STN local field potentials , 2018, Journal of Neuroscience Methods.

[6]  John-Stuart Brittain,et al.  Oscillations and the basal ganglia: Motor control and beyond , 2014, NeuroImage.

[7]  Peter Brown,et al.  The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson’s disease , 2017, Brain : a journal of neurology.

[8]  Alexander Münchau,et al.  Activity Parameters of Subthalamic Nucleus Neurons Selectively Predict Motor Symptom Severity in Parkinson's Disease , 2014, The Journal of Neuroscience.

[9]  H. Bergman,et al.  Longer β oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism , 2018, Movement disorders : official journal of the Movement Disorder Society.

[10]  Andrea A. Kühn,et al.  Frequency-dependent distribution of local field potential activity within the subthalamic nucleus in Parkinson's disease , 2007, Experimental Neurology.

[11]  Markus Butz,et al.  Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease , 2011, NeuroImage.

[12]  Karl J. Friston,et al.  Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. , 2011, Brain : a journal of neurology.

[13]  Jozsef Csicsvari,et al.  Disrupted Dopamine Transmission and the Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex , 2008, The Journal of Neuroscience.

[14]  A. Priori,et al.  Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease , 2004, Experimental Neurology.

[15]  P. Brown,et al.  Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease. , 2006, Cerebral cortex.

[16]  A. Oliviero,et al.  Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease , 2001, The Journal of Neuroscience.

[17]  Andrea A. Kühn,et al.  High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance , 2008, The Journal of Neuroscience.

[18]  S. Haber,et al.  Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys , 2016, eLife.

[19]  Andrea A. Kühn,et al.  Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity , 2009, Experimental Neurology.

[20]  Peter Brown,et al.  Continuous force decoding from deep brain local field potentials for Brain Computer Interfacing , 2017, 2017 8th International IEEE/EMBS Conference on Neural Engineering (NER).

[21]  G. Schneider,et al.  Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease , 2018, eLife.

[22]  Rafal Bogacz,et al.  Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson’s Disease , 2015, PLoS Comput. Biol..

[23]  Peter Brown,et al.  Subthalamic beta dynamics mirror Parkinsonian bradykinesia months after neurostimulator implantation , 2017, Movement disorders : official journal of the Movement Disorder Society.

[24]  Andrea A. Kühn,et al.  The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease , 2005, Experimental Neurology.

[25]  C. Koch,et al.  The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes , 2012, Nature Reviews Neuroscience.

[26]  D. Hand,et al.  Idiot's Bayes—Not So Stupid After All? , 2001 .

[27]  Thomas J. Watson,et al.  An empirical study of the naive Bayes classifier , 2001 .

[28]  J. Martinerie,et al.  The brainweb: Phase synchronization and large-scale integration , 2001, Nature Reviews Neuroscience.

[29]  P. Fries.  Rhythms for Cognition: Communication through Coherence , 2015, Neuron.

[30]  A. Engel,et al.  Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients , 2018, Neurobiology of Disease.

[31]  Siobhan Ewert,et al.  Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity , 2016, NeuroImage.

[32]  P. Brown,et al.  Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans , 2016, eLife.

[33]  H. Bronte-Stewart,et al.  Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients , 2019, Brain Stimulation.

[34]  Peter Brown,et al.  Complexity of subthalamic 13–35Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease , 2010, Experimental Neurology.

[35]  J. Dostrovsky,et al.  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. , 2006, Journal of neurophysiology.

[36]  T. Sejnowski,et al.  Correlated neuronal activity and the flow of neural information , 2001, Nature Reviews Neuroscience.

[37]  Claudio Pollo,et al.  Electrophysiological differences between upper and lower limb movements in the human subthalamic nucleus , 2019, Clinical Neurophysiology.

[38]  F. L. D. Silva,et al.  Event-related EEG/MEG synchronization and desynchronization: basic principles , 1999, Clinical Neurophysiology.

[39]  P. Brown,et al.  Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease , 2006, The European journal of neuroscience.

[40]  H. Bergman,et al.  Parkinsonism-related β oscillations in the primate basal ganglia networks - Recent advances and clinical implications. , 2019, Parkinsonism & related disorders.

[41]  Vladimir Litvak,et al.  Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson’s disease , 2016, Brain : a journal of neurology.

[42]  Michael X Cohen,et al.  Analyzing Neural Time Series Data: Theory and Practice , 2014 .

[43]  Peter Brown,et al.  Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson's disease , 2016, Movement disorders : official journal of the Movement Disorder Society.

[44]  Peter Brown,et al.  Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery , 2006, Experimental Neurology.

[45]  Peter Gemmar,et al.  PaCER - A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation , 2017, NeuroImage: Clinical.

[46]  P. Fries.  A mechanism for cognitive dynamics: neuronal communication through neuronal coherence , 2005, Trends in Cognitive Sciences.

[47]  P. Brown,et al.  Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance , 2018, The Journal of Neuroscience.

[48]  J. Millán,et al.  Beta-driven closed-loop deep brain stimulation can compromise human motor behavior in Parkinson’s Disease , 2019, bioRxiv.

[49]  P. Brown,et al.  Localization of beta and high-frequency oscillations within the subthalamic nucleus region , 2017, NeuroImage: Clinical.

[50]  Matthew D. Johnson,et al.  Closed-Loop Deep Brain Stimulation Effects on Parkinsonian Motor Symptoms in a Non-Human Primate – Is Beta Enough? , 2016, Brain Stimulation.

[51]  J. Dostrovsky,et al.  Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. , 2002, Brain : a journal of neurology.

[52]  Karl J. Friston,et al.  Basal ganglia–cortical interactions in Parkinsonian patients , 2013, NeuroImage.

[53]  Jorge Iriarte,et al.  Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease , 2010, The Journal of Neuroscience.

[54]  H. Bergman,et al.  Subthalamic theta activity: a novel human subcortical biomarker for obsessive compulsive disorder , 2018, Translational Psychiatry.

[55]  Nicola J. Ray,et al.  Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation , 2008, Experimental Neurology.

[56]  R. Bogacz,et al.  Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson’s Disease , 2018, Current Biology.

[57]  Sacha Jennifer van Albada,et al.  Mean-field modeling of the basal ganglia-thalamocortical system. II Dynamics of parkinsonian oscillations. , 2009, Journal of theoretical biology.

[58]  S Cerutti,et al.  300-Hz subthalamic oscillations in Parkinson's disease. , 2003, Brain : a journal of neurology.

[59]  Anca Velisar,et al.  Neuromodulation targets pathological not physiological beta bursts during gait in Parkinson's disease , 2018, Neurobiology of Disease.

[60]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[61]  Andrea A. Kühn,et al.  Beta bursts during continuous movements accompany the velocity decrement in Parkinson's disease patients , 2019, Neurobiology of Disease.

[62]  Hagai Bergman,et al.  Local vs. volume conductance activity of field potentials in the human subthalamic nucleus. , 2017, Journal of neurophysiology.

[63]  Raymond J. Dolan,et al.  Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism , 2011, PLoS Comput. Biol..

[64]  W. Singer,et al.  Dynamic predictions: Oscillations and synchrony in top–down processing , 2001, Nature Reviews Neuroscience.

[65]  Brian B. Avants,et al.  Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain , 2008, Medical Image Anal..

[66]  P. Brown,et al.  Adaptive Deep Brain Stimulation as an Advanced Parkinson’s disease Treatment (ADAPT): a pseudorandomised clinical trial , 2019 .

[67]  Andrea A. Kühn,et al.  Beta burst dynamics in Parkinson’s disease OFF and ON dopaminergic medication , 2017, Brain : a journal of neurology.

[68]  Abbey B. Holt,et al.  Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network , 2019, Proceedings of the National Academy of Sciences.

[69]  Peter Brown,et al.  Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease. , 2007, Brain : a journal of neurology.

[70]  Peter A. Robinson,et al.  Quantitative theory of deep brain stimulation of the subthalamic nucleus for the suppression of pathological rhythms in Parkinson’s disease , 2018, PLoS Comput. Biol..

[71]  Siobhan Ewert,et al.  Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging , 2018, NeuroImage.

[72]  Marko Robnik-Sikonja,et al.  Theoretical and Empirical Analysis of ReliefF and RReliefF , 2003, Machine Learning.

[73]  Allison T. Connolly,et al.  High-resolution local field potentials measured with deep brain stimulation arrays , 2018, Journal of neural engineering.

[74]  P. Brown,et al.  Adaptive Deep Brain Stimulation In Advanced Parkinson Disease , 2013, Annals of neurology.