论文信息 - Polysaccharide Sulfuric Acids as Anticoagulants.

Polysaccharide Sulfuric Acids as Anticoagulants.

Summary. 1 The preparation of synthetic polysaccharide sulfuric acids is studied, and their properties as anticoagulants jniwtigated. 2 A convenient method for the approximate determination of the strength of the anticoagulants is desrribed. 3 Tt is found that the action of the synthetic derivatives differs from that of heparin in that it is less influenced by large amounts of thrombokinase. 4 While they are quite harmless when given orally, they are more or less toxic when injected intravenously. Cellulose and starch sulfuric acids are the most toxic of the substances investigated, while chitin disulfuric acid is only slightly toxic. The last mentioned substance may be used as a suitable, inexpensive substitute for heparin in experimental work.

T. Astrup | M. Volkert | I. Galsmar

[1] R. Legler. Über die Kinetik der Blutgerinnung I , 1943 .

[2] P. Karrer,et al. Zur Kenntnis blutgerinnungshemmender Polysaccharid‐poly‐schwefelsäure‐ester und ähnlicher Verbindungen , 1943 .

[3] T. Astrup,et al. Properties of Throinbokinase (Thromboplastin) from Ox Lung , 1942 .

[4] T. Astrup,et al. On the Administration of Heparin Per os , 1939 .

[5] T. Astrup,et al. Purification of Heparin1 , 1938 .

[6] E. Chargaff,et al. STUDIES ON THE CHEMISTRY OF BLOOD COAGULATION VI. STUDIES ON THE ACTION OF HEPARIN AND OTHER ANTICOAGULANTS. THE INFLUENCE OF PROTAMINE ON THE ANTICOAGULANT EFFECT IN VIVO , 1937 .

[7] A. Tiselius,et al. Electrophoresis of serum globulin: Electrophoretic analysis of normal and immune sera. , 1937, The Biochemical journal.

[8] E. Chargaff,et al. STUDIES ON THE CHEMISTRY OF BLOOD COAGULATION II. ON THE INHIBITION OF BLOOD CLOTTING BY SUBSTANCES OF HIGH MOLECULAR WEIGHT , 1936 .

[9] S. Bergstrm. ber die Wirkungsgruppe des Heparins , 1935 .

[10] W. Traube,et al. Über Cellulose‐Schwefelsäure‐ester (II. Mitteil.) , 1932 .

[11] E. Gebauer-Fülnegg,et al. Schwefelsäure‐ester aus Cellulose. (Vorläufige Mitteilung.) , 1928 .

[12] S. Bergström. Über Polysacchaxidesterschwefelsäuren mit Heparinwirkung. , 1936 .