Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse

BMP-Sox9 signaling drives tumor cells to transdifferentiate into astrocytes, which contributes to the recurrence of SHH-driven medulloblastoma, a common type of pediatric brain tumor.

[1]  K. Rarick,et al.  Astrocytes influence medulloblastoma phenotypes and CD133 surface expression , 2020, PloS one.

[2]  Yi Zhao,et al.  NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma , 2020, Cell reports.

[3]  E. Cukierman,et al.  Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix , 2020, Laboratory Investigation.

[4]  Gary D Bader,et al.  Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor. , 2020, Cell reports.

[5]  B. Barres,et al.  Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth , 2020, Cell.

[6]  Emily J. Girard,et al.  Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. , 2019, Cancer cell.

[7]  T. Curran,et al.  Leukotriene Synthesis Is Critical for Medulloblastoma Progression , 2019, Clinical Cancer Research.

[8]  Volker Hovestadt,et al.  Resolving medulloblastoma cellular architecture by single-cell genomics , 2019, Nature.

[9]  M. Monje,et al.  ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma , 2019, Communications Biology.

[10]  Xia Li,et al.  Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells , 2018, Stem cell reports.

[11]  Steven J. M. Jones,et al.  Erratum: A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases (S0092867418301156 (2018) 172(5) (1050–1062.e14) (S0092867418301156) (10.1016/j.cell.2018.01.038)) , 2018 .

[12]  D. Moore,et al.  SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity , 2018, Bone Research.

[13]  T. Curran,et al.  Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma , 2018, Clinical Cancer Research.

[14]  T. Curran,et al.  Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion. , 2017, Cancer research.

[15]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[16]  J. Piechowski Hypothesis about Transdifferentiation As Backbone of Malignancy , 2017, Front. Oncol..

[17]  A. Benraiss,et al.  SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions , 2017, The Journal of Neuroscience.

[18]  David T. W. Jones,et al.  FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma , 2016, The EMBO journal.

[19]  Gary D. Bader,et al.  Divergent clonal selection dominates medulloblastoma at recurrence , 2016, Nature.

[20]  Matthias Mann,et al.  Cell type– and brain region–resolved mouse brain proteome , 2015, Nature Neuroscience.

[21]  F. Benfenati,et al.  Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors , 2014, Stem cell reports.

[22]  L. Yin,et al.  The versatile functions of Sox9 in development, stem cells, and human diseases , 2014, Genes & diseases.

[23]  Z. Tümer,et al.  Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage , 2014, Stem cell reports.

[24]  A. Bullock,et al.  Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants , 2014, Journal of medicinal chemistry.

[25]  Steven J. M. Jones,et al.  Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. , 2014, Cancer cell.

[26]  Roland Eils,et al.  Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. , 2014, Cancer cell.

[27]  David T. W. Jones,et al.  Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. , 2013, The Lancet. Oncology.

[28]  J. Briscoe,et al.  Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling , 2013, Proceedings of the National Academy of Sciences.

[29]  Scott L. Pomeroy,et al.  Medulloblastomics: the end of the beginning , 2012, Nature Reviews Cancer.

[30]  P. Northcott,et al.  Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. , 2012, Cancer cell.

[31]  B. Barres,et al.  Genomic Analysis of Reactive Astrogliosis , 2012, The Journal of Neuroscience.

[32]  R. Gronostajski,et al.  Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis , 2012, Neuron.

[33]  Scott L. Pomeroy,et al.  Molecular subgroups of medulloblastoma: the current consensus , 2011, Acta Neuropathologica.

[34]  G. Sapkota,et al.  The specificities of small molecule inhibitors of the TGFß and BMP pathways. , 2011, Cellular signalling.

[35]  K. Hochedlinger,et al.  Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. , 2011, Cell stem cell.

[36]  D. Ellison,et al.  Treatment of recurrent central nervous system primitive neuroectodermal tumours in children and adolescents: results of a Children's Cancer and Leukaemia Group study. , 2011, European journal of cancer.

[37]  R. Lovell-Badge,et al.  SOX9 induces and maintains neural stem cells , 2010, Nature Neuroscience.

[38]  H. Schöler,et al.  p53 connects tumorigenesis and reprogramming to pluripotency , 2010, The Journal of experimental medicine.

[39]  Jun O. Liu,et al.  Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. , 2010, Cancer cell.

[40]  Jeremy Stinson,et al.  Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. , 2009, The New England journal of medicine.

[41]  K. Graham,et al.  Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma. , 2009, Cancer research.

[42]  A. Lassar,et al.  The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization , 2009, Molecular and Cellular Biology.

[43]  Qiuhui Pan,et al.  Sox9, a key transcription factor of bone morphogenetic protein‐2‐induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter , 2008, Journal of cellular physiology.

[44]  Robert Machold,et al.  Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. , 2008, Cancer cell.

[45]  Tao Sun,et al.  Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. , 2008, Cancer cell.

[46]  F. Zindy,et al.  Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. , 2008, Genes & development.

[47]  S. Pons,et al.  Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc* , 2007, Journal of Biological Chemistry.

[48]  Bernhard Schmierer,et al.  TGFβ–SMAD signal transduction: molecular specificity and functional flexibility , 2007, Nature Reviews Molecular Cell Biology.

[49]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[50]  R. Hinton,et al.  BMP and FGF regulatory pathways in semilunar valve precursor cells , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[51]  David J. Anderson,et al.  The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord , 2006, Neuron.

[52]  Gord Fishell,et al.  Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors , 2005, Neuron.

[53]  D. Barry,et al.  Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord , 2005, Glia.

[54]  S. Pons,et al.  Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling , 2004, Development.

[55]  T. Himi,et al.  Cerebellar granule cell precursors can differentiate into astroglial cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Marie-Christine Chaboissier,et al.  The Sox9 transcription factor determines glial fate choice in the developing spinal cord. , 2003, Genes & development.

[57]  Marie-Christine Chaboissier,et al.  The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. , 2002, Genes & development.

[58]  H. Burtscher,et al.  The Transcription Factor Sox9 Is Involved in BMP‐2 Signaling , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  L. Rorke,et al.  Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[60]  H. Bengtsson,et al.  Bone morphogenetic proteins and their receptors: Potential functions in the brain , 1998, Journal of neuroscience research.

[61]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[62]  M. Scott,et al.  Altered neural cell fates and medulloblastoma in mouse patched mutants. , 1997, Science.

[63]  M. Mehler,et al.  Bone morphogenetic proteins in the nervous system , 1997, Trends in Neurosciences.

[64]  H Sugimura,et al.  Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. , 1996, Cancer research.

[65]  K. Mikoshiba,et al.  A Novel Zinc Finger Protein, Zic, Is Involved in Neurogenesis, Especially in the Cell Lineage of Cerebellar Granule Cells , 1994, Journal of neurochemistry.

[66]  S. Rochkind,et al.  Extracranial metastases of medulloblastoma in adults: literature review. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[67]  Joel I. Pritchard,et al.  BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect , 2003, Nature Medicine.