Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
暂无分享,去创建一个
D. Tweardy | Xuejun Xu | M. Kasembeli | Xueqing Jiang | Benjamin J. Tweardy | Xuejun Xu | Moses M. Kasembeli | Xueqing Jiang | David J. Tweardy
[1] Arlin G. Cameron,et al. Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. , 2005, Journal of medicinal chemistry.
[2] Qiqing Zhu,et al. Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3 , 2007, J. Comput. Aided Mol. Des..
[3] H. Kutsuna,et al. Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. , 2004, The Journal of biological chemistry.
[4] D. Tweardy,et al. Targeting transcription factors for cancer therapy. , 2005, Current pharmaceutical design.
[5] V. Poli,et al. Stat3 Isoforms, α and β, Demonstrate Distinct Intracellular Dynamics with Prolonged Nuclear Retention of Stat3β Mapping to Its Unique C-terminal End* , 2007, Journal of Biological Chemistry.
[6] R. Schreiber,et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[7] J. Clardy,et al. Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. , 2006, Organic letters.
[8] D. Frank. Targeting transcription factors for cancer therapy. , 2008, IDrugs : the investigational drugs journal.
[9] Bernd Groner,et al. TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX , 1999 .
[10] Hua Yu,et al. The STATs of cancer — new molecular targets come of age , 2004, Nature Reviews Cancer.
[11] T. Hsu,et al. Cytogenetic analysis on eight human breast tumor cell lines: high frequencies of 1q, 11q and HeLa-like marker chromosomes. , 1981, Cancer Genetics and Cytogenetics.
[12] N. Jing,et al. Targeting Stat3 in cancer therapy. , 2005, Anti-cancer drugs.
[13] L. Mao,et al. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer , 2006, Molecular Cancer Therapeutics.
[14] J. Darnell,et al. Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA , 1998, Cell.
[15] J. Darnell,et al. Stat3 as an Oncogene , 1999, Cell.
[16] V. Poli,et al. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. , 2007, The Journal of biological chemistry.
[17] I. Fidler,et al. Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. , 1991, Invasion & metastasis.
[18] Hua Yu,et al. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells , 2001, Oncogene.
[19] D. Tweardy,et al. Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. , 1995, Blood.
[20] William P. Katt,et al. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. , 2007, ACS chemical biology.
[21] Jürgen Bajorath,et al. Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches. , 2007, Drug discovery today.
[22] R. Schreiber,et al. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice , 1998 .
[23] S. Becker,et al. Structure of the Unphosphorylated STAT5a Dimer* , 2005, Journal of Biological Chemistry.
[24] Bianca Sperl,et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. , 2006, Chemistry & biology.
[25] D. Keene,et al. A Novel Binding Site in Collagen Type III for Integrins α1β1 and α2β1* , 2005, Journal of Biological Chemistry.
[26] H. Scheraga,et al. Energy parameters in polypeptides. 10. Improved geometrical parameters and nonbonded interactions for use in the ECEPP/3 algorithm, with application to proline-containing peptides , 1994 .
[27] D. Tweardy,et al. Targeting transcription factors in cancer: Challenges and evolving strategies. , 2006, Drug discovery today. Technologies.
[28] K. Hess,et al. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo , 2007, Oncogene.
[29] J. Darnell,et al. Validating Stat3 in cancer therapy , 2005, Nature Medicine.
[30] B. Brinkley,et al. Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. , 1980, Cancer research.
[31] R Abagyan,et al. Flexible protein–ligand docking by global energy optimization in internal coordinates , 1997, Proteins.
[32] S. Becker,et al. Three-dimensional structure of the Stat3β homodimer bound to DNA , 1998, Nature.
[33] J. Turkson,et al. STAT proteins: novel molecular targets for cancer drug discovery , 2000, Oncogene.
[34] Michael S. Cohen,et al. Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors , 2005, Science.
[35] Wei Zhang,et al. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. , 2005, The American journal of pathology.
[36] STAT3: A critical transcription activator in angiogenesis , 2008, Medicinal research reviews.
[37] Renxiao Wang,et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[38] Bulbul Pandit,et al. Design, synthesis, and studies of small molecule STAT3 inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[39] Hua Yu,et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity , 2005, Nature Medicine.
[40] N. Jing,et al. G-Quartet Oligonucleotides , 2004, Cancer Research.
[41] Huang Shao,et al. Unique Structural Determinants for Stat3 Recruitment and Activation by the Granulocyte Colony-Stimulating Factor Receptor at Phosphotyrosine Ligands 704 and 7441 , 2006, The Journal of Immunology.
[42] R. Schreiber,et al. Cancer immunoediting: from immunosurveillance to tumor escape , 2002, Nature Immunology.
[43] H. Kutsuna,et al. Proteolytic Conversion of STAT3α to STAT3γ in Human Neutrophils , 2004, Journal of Biological Chemistry.
[44] Adam T. Szafran,et al. Erratum: Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-independent (J. Cell Sci. vol. 119 (4101-4116)) , 2006 .
[45] G. Stark,et al. Complex roles of Stat1 in regulating gene expression , 2000, Oncogene.
[46] R. Cook,et al. Structural Requirements for Signal Transducer and Activator of Transcription 3 Binding to Phosphotyrosine Ligands Containing the YXXQ Motif* , 2004, Journal of Biological Chemistry.
[47] W. Guida,et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity , 2007, Proceedings of the National Academy of Sciences.
[48] Adam T. Szafran,et al. Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent , 2006, Journal of Cell Science.
[49] L. Costantino,et al. STAT 3 as a target for cancer drug discovery. , 2008, Current medicinal chemistry.
[50] G. Heijne,et al. Structural Bioinformatics-Based Design of Selective , Irreversible Kinase Inhibitors , 2005 .
[51] N. Jing,et al. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. , 2003, DNA and cell biology.
[52] M. Olivé,et al. Long-term human breast carcinoma cell lines of metastatic origin: Preliminary characterization , 1978, In Vitro.
[53] D. Tweardy,et al. Cross-talk Between Retinoic Acid and STAT3 Signaling Pathways in Acute Promyelocytic Leukemia , 2003, Leukemia & lymphoma.
[54] R. Jove,et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[55] Shaomeng Wang,et al. Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'. , 2007, Bioorganic & medicinal chemistry letters.
[56] J. McMurray. A new small-molecule Stat3 inhibitor. , 2006, Chemistry & biology.