Vitamin E correlates inversely with non‐transferrin‐bound iron in sickle cell disease

Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non‐transferrin‐bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age‐/sex‐matched controls (P < 0·001), but NTBI (bleomycin assay) was higher (P < 0·001). Vitamin E was lower in 10 transfused patients than in 20 non‐transfused patients (P < 0·001) with a significant inverse correlation between the NTBI and vitamin E (r = −0·58, P < 0·001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.

[1]  S. Urien,et al.  Role of bilirubin in the regulation of the total peroxyl radical trapping antioxidant activity of plasma in sickle cell disease. , 1998, Biochemical and biophysical research communications.

[2]  L. Tesoriere,et al.  Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. , 1996, Blood.

[3]  I. Young,et al.  Antioxidant status and lipid peroxidation in hereditary haemochromatosis. , 1994, Free radical biology & medicine.

[4]  B. Halliwell,et al.  The role of oxygen radicals in human disease, with particular reference to the vascular system. , 1993, Haemostasis.

[5]  T. Sugihara,et al.  Detection, characterization, and bioavailability of membrane-associated iron in the intact sickle red cell. , 1992, Journal of Clinical Investigation.

[6]  H. Yasuda,et al.  The effect of α-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites , 1991 .

[7]  竹中 義人.  The effect of α-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites , 1991 .

[8]  E. Niki,et al.  Membrane damage due to lipid oxidation. , 1991, The American journal of clinical nutrition.

[9]  S. Jain.  Vitamin E and Membrane Abnormalities in Red Cells of Sickle Cell Disease Patients and Newborn Infants , 1989 .

[10]  H. Stähelin,et al.  Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. , 1987, The American journal of clinical nutrition.

[11]  J. Gutteridge,et al.  Iron complexes and their reactivity in the bleomycin assay for radical-promoting loosely-bound iron. , 1986, Free radical research communications.

[12]  J. Eaton,et al.  Spontaneous oxygen radical generation by sickle erythrocytes. , 1982, The Journal of clinical investigation.

[13]  E. Vichinsky,et al.  PEROXIDATION, VITAMIN E, AND SICKLE‐CELL ANEMIA * , 1982, Annals of the New York Academy of Sciences.