Continuous Blood Pressure Estimation from PPG Signal

Given the importance of blood pressure (BP) as a direct indicator of hypertension, regular monitoring is encouraged for healthy people and mandatory for patients at risk from cardiovascular diseases. We propose a system in which photoplethysmogram (PPG) is used to continuously estimate BP. A PPG sensor can be easily embedded in a modern wearable device, which can be used in such an approach. A set of features describing the PPG signal on a per-cycle basis is computed to be used in regression models. The predictive performance of the models is improved by rst using the RReliefF algorithm to select a subset of relevant features. Afterwards, personalization of the models is considered to further improve the performance. The approach is validated using two distinct datasets, one from a hospital environment and the other collected during every-day activities. Using the MIMIC hospital dataset, the best achieved mean absolute errors (MAE) in a leave-one-subject-out (LOSO) experiment were 4.47 +- 5.85 mmHg for systolic and 2.02 +- 2.94 mmHg for diastolic BP, at maximum personalization. For everyday-life dataset, the lowest errors in the same LOSO experiment were 8.57 +- 7.93 mmHg for systolic and 4.42 +- 3.61 mmHg for diastolic BP, again using maximum personalization.

[1]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[2]  Mingshan Sun,et al.  Optical blood pressure estimation with photoplethysmography and FFT-based neural networks. , 2016, Biomedical optics express.

[3]  Domenico Grimaldi,et al.  A Neural Network-based method for continuous blood pressure estimation from a PPG signal , 2013, 2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC).

[4]  Ethel M. Frese,et al.  Blood Pressure Measurement Guidelines for Physical Therapists , 2011, Cardiopulmonary physical therapy journal.

[5]  Q Li,et al.  Dynamic time warping and machine learning for signal quality assessment of pulsatile signals , 2012, Physiological measurement.

[6]  Wendy Van Moer,et al.  Application of the Artificial Neural Network for blood pressure evaluation with smartphones , 2013, 2013 IEEE 7th International Conference on Intelligent Data Acquisition and Advanced Computing Systems (IDAACS).

[7]  Marko Robnik-Sikonja,et al.  Theoretical and Empirical Analysis of ReliefF and RReliefF , 2003, Machine Learning.

[8]  Jesús Lázaro,et al.  Pulse Rate Variability Analysis for Discrimination of Sleep-Apnea-Related Decreases in the Amplitude Fluctuations of Pulse Photoplethysmographic Signal in Children , 2014, IEEE Journal of Biomedical and Health Informatics.

[9]  G. Moody,et al.  A database to support development and evaluation of intelligent intensive care monitoring , 1996, Computers in Cardiology 1996.

[10]  Andrew Shennan,et al.  Validation of the Omron M7 (HEM-780-E) oscillometric blood pressure monitoring device according to the British Hypertension Society protocol , 2008, Blood pressure monitoring.

[11]  Toshiyo Tamura,et al.  Wearable Photoplethysmographic Sensors—Past and Present , 2014 .

[12]  David Moratal Biomedical Signal and Image Processing, 2nd Edition [Book Reviews] , 2014, IEEE Pulse.

[13]  Y.T. Zhang,et al.  Continuous and noninvasive estimation of arterial blood pressure using a photoplethysmographic approach , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).