Cellular anomalies underlying retinoid-induced phocomelia.

[1]  T. Underhill,et al.  Revisiting the role of retinoid signaling in skeletal development. , 2003, Birth defects research. Part C, Embryo today : reviews.

[2]  D. Kochhar,et al.  PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects. , 2002, Teratology.

[3]  G. Martin,et al.  Functions of FGF signalling from the apical ectodermal ridge in limb development , 2002, Nature.

[4]  T. Underhill,et al.  Retinoid signalling and skeletal development. , 2001, Novartis Foundation symposium.

[5]  C. Martínez-A,et al.  Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. , 2000, Development.

[6]  N. Manley,et al.  Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. , 1998, Teratology.

[7]  C. Tabin A developmental model for thalidomide defects , 1998, Nature.

[8]  W. Hong,et al.  All-trans-retinoic Acid Increases Transforming Growth Factor-β2 and Insulin-like Growth Factor Binding Protein-3 Expression through a Retinoic Acid Receptor-α-dependent Signaling Pathway* , 1997, The Journal of Biological Chemistry.

[9]  M. Cunningham,et al.  Retinoic acid exposure of the mouse on embryonic day 9 selectively spares derivatives of the frontonasal neural crest. , 1997, Journal of craniofacial genetics and developmental biology.

[10]  D. Frenz,et al.  Retinoic acid-induced embryopathy of the mouse inner ear. , 1996, Teratology.

[11]  K. Patel,et al.  Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds. , 1996, Development.

[12]  Philippe Kastner,et al.  Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life? , 1995, Cell.

[13]  S. Li,et al.  Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors. , 1995, The International journal of developmental biology.

[14]  C. Tickle,et al.  Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: Their relationships in the signalling cascade involved in limb patterning , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[15]  Y. M. Lee,et al.  Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells. , 1995, Development.

[16]  M. Sporn,et al.  Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF‐β , 1994, Journal of cellular physiology.

[17]  B. Olwin,et al.  FGF-2: apical ectodermal ridge growth signal for chick limb development. , 1994, Science.

[18]  C. Tickle,et al.  FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb , 1993, Cell.

[19]  H. Jiang,et al.  Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud. , 1992, Teratology.

[20]  C. W. Ragsdale,et al.  Retinoids and their targets in vertebrate development. , 1991 .

[21]  P. Chambon,et al.  Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. , 1991, Development.

[22]  K. Sulik,et al.  Retinoic-acid-induced limb-reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism. , 1989, Teratology.

[23]  D. Kochhar,et al.  Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb-buds associated with limb dysmorphogenesis. , 1989, Developmental biology.

[24]  T. D. Stephens Proposed mechanisms of action in thalidomide embryopathy. , 1988, Teratology.

[25]  F. Mallein-Gerin,et al.  Temporal and spatial analysis of cartilage proteoglycan core protein gene expression during limb development by in situ hybridization. , 1988, Developmental biology.

[26]  D. Heinegård,et al.  Evidence for sequential appearance of cartilage matrix proteins in developing mouse limbs and in cultures of mouse mesenchymal cells. , 1987, Differentiation; research in biological diversity.

[27]  Runner Mn Epigenetically regulated genomic expressions for shortened stature and cleft palate are regionally specific in the 11-day mouse embryo. , 1986 .

[28]  P. Fernhoff,et al.  Retinoic acid embryopathy. , 1985, The New England journal of medicine.

[29]  J. Hersh,et al.  Retinoic acid embryopathy: timing of exposure and effects on fetal development. , 1985, JAMA.

[30]  T. Sadler,et al.  Effects of vitamin A on endocardial cushion development in the mouse heart. , 1981, Teratology.

[31]  D. Newall,et al.  The effect of vitamin A on fusion of mouse palates. II. retinyl palmitate, retinol, and retinoic acid in vitro. , 1981, Teratology.

[32]  D. Kochhar,et al.  Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme. , 1980, Journal of embryology and experimental morphology.

[33]  Geelen Ja Hypervitaminosis A Induced Teratogenesis , 1979 .

[34]  T. Linsenmayer,et al.  In vitro cartilage formation: effects of 6-diazo-5-oxo-L-norleucine (DON) on glycosaminoglycan and collagen synthesis. , 1979, Developmental biology.

[35]  J. Howard,et al.  Cellular basis of congenital limb deformity induced in mice by vitamin A. , 1977 .

[36]  J. Lewis,et al.  Time, place and positional value in the chick limb-bud. , 1975, Journal of embryology and experimental morphology.

[37]  D. Kochhar Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid. , 1973, Teratology.

[38]  R. Smithells Defects and Disabilities of Thalidomide Children , 1973, British medical journal.

[39]  R E Shenefelt,et al.  Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment. , 1972, Teratology.

[40]  D. Kochhar Teratogenic activity of retinoic acid. , 2009, Acta pathologica et microbiologica Scandinavica.

[41]  L. Gillis Thalidomide Babies: Management of Limb Defects , 1962, British medical journal.