Modulatory effect of vitamin E and C on SO^ induced hematological alterations in albino rats

The present study aimed to investigate the alterations in selected hematological parameters (total erythrocyte count, total leucocyte count, hemoglobin concentration, packed cell volume, erythrocyte sedimentation rate and red cell indices(MC V, MCH, MCHC) of wistar albino rats after short term (80 ppm, 1 h/ d for 28 days) exposure to SO ^ gas and protective effect of vitamin E (2.5mg/rat) andC (5mg/rat) individually and In combination. The results of the present study imply that hematological parameters altered after SO^ gas inhalation and lead to reduction in TEC, Hb.Conc, PCVand red cell indices, while elevation in TLC and ESR. However, SO^ induced hematological alterations modulated after supplementation of vitamin E and C individually and in combination due to antioxidant defense mechanism against toxic action of SO^ inhalation. The findings of the present study exhibit that the supplementation of vitamin E and C in combination have more potential to mitigate SO^ induced hematological alterations in albino rats than the supplementation of vitamin E and C individually.

[1]  C. Magdum.  IN VIVO SCREENING OF ANTIOXIDANT PROFILE: A REVIEW , 2008 .

[2]  John E. Hall,et al.  Textbook of Medical Physiology 11th ed. , 2006 .

[3]  O. Baskurt,et al.  Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects. , 2005, Journal of applied physiology.

[4]  R. Telford,et al.  Changes in the susceptibility of red blood cells to oxidative and osmotic stress following submaximal exercise , 2004, European Journal of Applied Physiology and Occupational Physiology.

[5]  K. Torén,et al.  Mortality from asthma and cancer among sulfite mill workers. , 1998, Scandinavian journal of work, environment & health.

[6]  M. Tuncer,et al.  Protective Effect of Antioxidant Vitamins on Red Blood Cell Lipoperoxidation induced by SO2 inhalation , 1997, Journal of basic and clinical physiology and pharmacology.

[7]  O. Etlik,et al.  The effects of sulfur dioxide inhalation and antioxidant vitamins on red blood cell lipoperoxidation. , 1995, Environmental Research.

[8]  O. Aruoma,et al.  The characterization of antioxidants. , 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[9]  M. Béjot,et al.  Influence of Beta Carotene, Vitamin E, and Vitamin C on Endogenous Antioxidant Defenses in Erythrocytes , 1993, The Annals of pharmacotherapy.

[10]  K. K. Dutta,et al.  Histomorphological changes in lung of rats following exposure to wood smoke. , 1993, Indian journal of experimental biology.

[11]  A. Tewari,et al.  Air Pollution - Adverse Effects of Sulfur Dioxide , 1991, Reviews on environmental health.

[12]  A. Yalçın,et al.  Effect of chronic halothane exposure on lipid peroxidation, osmotic fragility and morphology of rat erythrocytes , 1990, Journal of applied toxicology : JAT.

[13]  S. Jain,et al.  Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. , 1989, The Journal of biological chemistry.

[14]  S. Haider.  Effects of exhaust pollutant sulfur dioxide on lipid metabolism of guinea pig organs. , 1985, Industrial health.