Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
暂无分享,去创建一个
Hiroki Tsumoto | Katsuhiko Shirahige | Yukihiro Itoh | Takayoshi Suzuki | Ryuzo Ueda | K. Shirahige | Yukihiro Itoh | Takayoshi Suzuki | S. Iida | R. Ueda | T. Mizukami | N. Miyata | M. Bando | H. Nakagawa | H. Tsumoto | Naoki Miyata | Masashige Bando | Yosuke Ota | Prima R Tatum | Yosuke Ota | Hidehiko Nakagawa | Masaki Ri | Aogu Gotoh | Tamio Mizukami | Shinsuke Iida | M. Ri | Aogu Gotoh
[1] D. Christianson,et al. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. , 2011, Journal of the American Chemical Society.
[2] M. Varasi,et al. Nicotinoyl azide (NCA)-mediated Mitsunobu reaction: An expedient one-pot transformation of alcohols into azides , 2004 .
[3] S. Matsuoka,et al. Synthesis and biological evaluation of triazole analogues of antillatoxin , 2011 .
[4] Karunakaran A Kalesh,et al. High-throughput discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry. , 2009, Organic letters.
[5] S. Oh,et al. An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds , 2007 .
[6] T. Suzuki,et al. Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. , 1999, Journal of medicinal chemistry.
[7] Michelle R. Arkin,et al. Small-molecule inhibitors of protein–protein interactions: progressing towards the dream , 2004, Nature Reviews Drug Discovery.
[8] V. Fokin,et al. Cu‐Catalyzed Azide‐Alkyne Cycloaddition: Preparation of Tris((1‐Benzyl‐1H‐1,2,3‐Triazolyl)Methyl)Amine , 2012 .
[9] V. Castronovo,et al. Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. , 2004, The American journal of pathology.
[10] T. Nakano,et al. Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. , 2009, Journal of medicinal chemistry.
[11] Karunakaran A Kalesh,et al. Methods of using click chemistry in the discovery of enzyme inhibitors , 2007, Nature Protocols.
[12] G. Zanardi,et al. Reaction of Azides with Dichloroindium Hydride: Very Mild Production of Amines and Pyrrolidin-2-imines Through Possible Indium—Aminyl Radicals. , 2006 .
[13] R. De Francesco,et al. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[14] P. Atadja,et al. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. , 2011, Bioorganic & medicinal chemistry.
[15] Michele Pallaoro,et al. HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics , 2007, Cell Research.
[16] Yukihiro Itoh,et al. Isoform-selective histone deacetylase inhibitors. , 2008, Current pharmaceutical design.
[17] Eric Verdin,et al. Histone deacetylase HDAC8 associates with smooth muscle α‐actin and is essential for smooth muscle cell contractility , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[18] M. Binaschi,et al. Histone deacetylase inhibitors: from bench to clinic. , 2008, Journal of medicinal chemistry.
[19] M. Navre,et al. Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. , 2010, Bioorganic & medicinal chemistry letters.
[20] Morten Meldal,et al. Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. , 2002, The Journal of organic chemistry.
[21] P. Marks,et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[22] M. Karamouzis,et al. Focus on acetylation: the role of histone deacetylase inhibitors in cancer therapy and beyond , 2007, Expert opinion on investigational drugs.
[23] R A Rifkind,et al. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[24] S. Schreiber,et al. Discovery of Histone Deacetylase 8 Selective Inhibitors. , 2012 .
[25] Minoru Yoshida,et al. Protein deacetylases: enzymes with functional diversity as novel therapeutic targets. , 2003, Progress in cell cycle research.
[26] P. Wang,et al. Histone deacetylase inhibitors through click chemistry. , 2008, Journal of medicinal chemistry.
[27] Takayoshi Suzuki,et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. , 2005, Journal of medicinal chemistry.
[28] Silvio Massa,et al. Histone deacetylation in epigenetics: An attractive target for anticancer therapy , 2005, Medicinal research reviews.
[29] M. Uttamchandani,et al. Rapid assembly of matrix metalloprotease inhibitors using click chemistry. , 2006, Organic letters.
[30] Thomas A. Miller,et al. Histone deacetylase inhibitors. , 2003, Journal of medicinal chemistry.
[31] A. Oyelere,et al. Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group. , 2008, Bioorganic & medicinal chemistry.
[32] M. Jung,et al. Chromatin Modifications as Targets for New Anticancer Drugs , 2005, Archiv der Pharmazie.
[33] J. R. Somoza,et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. , 2004, Structure.
[34] Guoxian Gu,et al. Structure-based optimization of click-based histone deacetylase inhibitors. , 2011, European journal of medicinal chemistry.
[35] J. Buggy,et al. Interferon-α is able to maintain complete molecular remission induced by imatinib after its discontinuation , 2008, Leukemia.
[36] Barbara Hero,et al. Histone Deacetylase 8 in Neuroblastoma Tumorigenesis , 2009, Clinical Cancer Research.
[37] Y. Oda,et al. Expression profile of class I histone deacetylases in human cancer tissues. , 2007, Oncology reports.
[38] C. Fierke,et al. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . , 2010, Biochemistry.
[39] Chi‐Huey Wong,et al. A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry , 2003 .
[40] Ricardo Macarron,et al. Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases , 2003, Journal of Pharmacology and Experimental Therapeutics.
[41] S. Horinouchi,et al. Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.
[42] Yukihiro Itoh,et al. Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. , 2007, Journal of medicinal chemistry.
[43] R. De Francesco,et al. Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex , 2007, EMBO reports.
[44] T. Kummalue,et al. The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain , 2003, Molecular and Cellular Biology.
[45] C. Fierke,et al. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. , 2008, Biochemistry.
[46] Yukihiro Itoh,et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. , 2006, Journal of medicinal chemistry.
[47] Stuart L Schreiber,et al. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. , 2002, Chemistry & biology.
[48] Luke G Green,et al. A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. , 2002, Angewandte Chemie.
[49] J. Clark,et al. Cloning and characterization of a novel human histone deacetylase, HDAC8. , 2000, The Biochemical journal.
[50] Mahesh Uttamchandani,et al. Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. , 2006, Organic letters.
[51] Takayoshi Suzuki,et al. An unexpected example of protein-templated click chemistry. , 2010, Angewandte Chemie.
[52] E. Seto,et al. Acetylation and deacetylation of non-histone proteins. , 2005, Gene.
[53] Takayoshi Suzuki,et al. Epigenetic control using natural products and synthetic molecules. , 2006, Current medicinal chemistry.
[54] M. G. Finn,et al. Click Chemistry: Diverse Chemical Function from a Few Good Reactions , 2001 .
[55] Eric Verdin,et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[56] A. Giannis,et al. Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes. , 2005, Angewandte Chemie.
[57] James D. Winkler,et al. Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor* , 2000, The Journal of Biological Chemistry.
[58] Giuseppe Bifulco,et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. , 2010, Journal of medicinal chemistry.
[59] Gabriele Gillessen-Kaesbach,et al. HDAC8 mutations in Cornelia de Lange Syndrome affect the cohesin acetylation cycle , 2012, Nature.
[60] Minoru Yoshida,et al. [Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A]. , 1990, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.