Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats

An operant behavioral study on morphine addiction utilized a self-injection technique for giving intravenous injections to relatively unrestrained rats. The rate of self-injection varied inversely with the dose. Morphine was a reinforcer that produced almost immediate satiation.

[1]  L. A. Woods The pharmacology of nalorphine (N-allylnormorphine). , 1956, Pharmacological reviews.

[2]  M. Seevers ANIMAL EXPERIMENTATION IN STUDYING ADDICTION TO THE NEWER SYNTHETIC ANALGESICS , 1948, Annals of the New York Academy of Sciences.

[3]  V. Popovic,et al.  Permanent cannulation of aorta and vena cava in rats and ground squirrels. , 1960, Journal of applied physiology.

[4]  H. D. Beach Morphine addiction in rats. , 1957, Canadian journal of psychology.