Lack of Teratogenicity after Combined Exposure of Pregnant Mice to CDMA and WCDMA Radiofrequency Electromagnetic Fields

Abstract Concern about the possible adverse effects of radiofrequency (RF)-field exposure on public health has increased because of the extensive use of wireless mobile phones and other telecommunication devices in daily life. The murine fetus is a very sensitive indicator of the effects of stress or stimuli in the environment. Therefore, we investigated the teratogenic effects of multi-signal radiofrequency electromagnetic fields (RF EMFs) on mouse fetuses. Pregnant mice were simultaneously exposed to two types of RF signals, single code division multiple access (CDMA) and wideband code division multiple access (WCDMA). Mice received two 45-min RF-field exposures, separated by a 15-min interval, daily throughout the entire gestation period. The whole-body average specific absorption rate (SAR) of CDMA or WCDMA was 2.0 W/kg. The animals were killed humanely on the 18th day of gestation and fetuses were examined for mortality, growth retardation, changes in head size and other morphological abnormalities. From the results, we report for the first time that simultaneous experimental exposure to CDMA and WCDMA RF EMFs did not cause any observable adverse effects on mouse fetuses.

[1]  J. Juutilainen,et al.  Developmental effects of extremely low frequency electric and magnetic fields. , 2003, Radiation protection dosimetry.

[2]  D. McRee,et al.  Effects of 2.45 GHz CW microwave radiation on embryofetal development in mice. , 1981, Teratology.

[3]  Jukka Juutilainen,et al.  Developmental effects of electromagnetic fields , 2005, Bioelectromagnetics.

[4]  G. Eichholz Non-ionizing Radiation, Part 1: Static and Extremely Low-frequency (elf) Electric and Magnetic Fields, , 2002 .

[5]  J. Juutilainen,et al.  Effects of gestational exposure to a video display terminal-like magnetic field (20-kHz) on CBA/S mice. , 1998, Teratology.

[6]  Kanako Wake,et al.  Effects of gestational exposure to 1.95‐GHz W‐CDMA signals for IMT‐2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats , 2009, Bioelectromagnetics.

[7]  S. Tofani,et al.  Effects of continuous low-level exposure to radiofrequency radiation on intrauterine development in rats. , 1986, Health physics.

[8]  Louis N Heynick,et al.  Radiofrequency fields and teratogenesis , 2003, Bioelectromagnetics.

[9]  Kanako Wake,et al.  Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N‐ethylnitrosourea induced central nervous system tumors in F344 rats , 2005, Bioelectromagnetics.

[10]  J. Marcickiewicz,et al.  Effects of microwave exposure in utero on embryonal, fetal and postnatal development of mice. , 1983, Biology of the neonate.

[11]  C A Kimmel,et al.  A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. , 1981, Stain technology.

[12]  James G. Wilson,et al.  EMBRYOLOGICAL CONSIDERATIONS IN TERATOLOGY * , 1965, Annals of the New York Academy of Sciences.

[13]  H. B. Carter,et al.  Decreased body weight in fetal rats after irradiation with 2450-MHz (CW) microwaves. , 1984, Health physics.