Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
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Andriy Luzhetskyy | Andreas Bechthold | C. Hertweck | A. Bechthold | Christian Hertweck | Y. Rebets | A. Luzhetskyy | Yuri Rebets
[1] D. Hopwood,et al. Proof that the ACTVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin. , 1999, Bioorganic & medicinal chemistry letters.
[2] J. Rohr,et al. INACTIVATION OF THE URDGT2 GENE, WHICH ENCODES A GLYCOSYLTRANSFERASE RESPONSIBLE FOR THE C-GLYCOSYLTRANSFER OF ACTIVATED D-OLIVOSE, LEADS TO FORMATION OF THE NOVEL URDAMYCINS I, J, AND K , 1999 .
[3] C. Hutchinson,et al. Purification and characterization of the DNA‐binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius , 1996, Molecular microbiology.
[4] S. Mangenot,et al. Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome , 2004, Antimicrobial Agents and Chemotherapy.
[5] C R Hutchinson,et al. Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases. , 2001, Journal of natural products.
[6] K. Chater,et al. Evidence from proteomics that some of the enzymes of actinorhodin biosynthesis have more than one form and may occupy distinctive cellular locations , 2003, Journal of Industrial Microbiology and Biotechnology.
[7] S. Horinouchi,et al. Involvement of two A‐factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis , 1998, Molecular microbiology.
[8] J. Piel,et al. A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A. , 2002, Chemistry & biology.
[9] Y. Ebizuka,et al. A New Mode of Stereochemical Control Revealed by Analysis of the Biosynthesis of Dihydrogranaticin in Streptomyces violaceoruber Tü22 , 2001 .
[10] C. Walsh,et al. Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. , 2004, Biochemistry.
[11] Ichinose,et al. Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates. , 2000, Angewandte Chemie.
[12] C. Hertweck,et al. A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns. , 2004, Journal of the American Chemical Society.
[13] C. Méndez,et al. Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. , 2002, Chemistry & biology.
[14] D. Hoffmeister,et al. Rational Saccharide Extension by Using the Natural Product Glycosyltransferase LanGT4 , 2004, Chembiochem : a European journal of chemical biology.
[15] C. Khosla,et al. Kinetic Analysis of the Actinorhodin Aromatic Polyketide Synthase* , 1999, The Journal of Biological Chemistry.
[16] C. Hutchinson,et al. Doxorubicin Overproduction in Streptomyces peucetius: Cloning and Characterization of the dnrU Ketoreductase anddnrV Genes and the doxA Cytochrome P-450 Hydroxylase Gene , 1999, Journal of bacteriology.
[17] J. Strap,et al. Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation. , 2000, Microbiology.
[18] K. Chater,et al. Genetics of differentiation in Streptomyces. , 1993, Annual review of microbiology.
[19] J. Rohr,et al. The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. , 2003, Journal of the American Chemical Society.
[20] P. Warren,et al. Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery. , 2001, Drug discovery today.
[21] J. Bailey,et al. Collinone, a new recombinant angular polyketide antibiotic made by an engineered Streptomyces strain. , 2001, The Journal of antibiotics.
[22] S. Burston,et al. Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein. , 2005, Biochemistry.
[23] B. Moore,et al. Characterization of Benzoyl Coenzyme A Biosynthesis Genes in the Enterocin-Producing Bacterium “Streptomyces maritimus” , 2003, Journal of bacteriology.
[24] A. Bechthold,et al. A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. , 2006, FEMS microbiology letters.
[25] J. W. Campbell,et al. Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. , 2001, Annual review of microbiology.
[26] Chaitan Khosla,et al. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. , 2003, Structure.
[27] M. Ozawa,et al. Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters. , 2003, Microbiology.
[28] S. Fetzner. Oxygenases without requirement for cofactors or metal ions , 2002, Applied Microbiology and Biotechnology.
[29] E. Wendt-Pienkowski,et al. Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis. , 1998, Biochemistry.
[30] B. Barrell,et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) , 2002, Nature.
[31] R. Silvestrini,et al. ‘Daunomycin’, a New Antibiotic of the Rhodomycin Group , 1964, Nature.
[32] C. Hutchinson,et al. Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus , 1995, Journal of bacteriology.
[33] Shiou-Chuan Tsai,et al. Polyketide chain length control by chain length factor. , 2003, Journal of the American Chemical Society.
[34] F. Malpartida,et al. A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator. , 2001, Microbiology.
[35] P. Mäntsälä,et al. Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster. , 2002, Gene.
[36] C. Khosla,et al. Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively , 1994 .
[37] J. Caballero,et al. DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2). , 1994, The Journal of biological chemistry.
[38] A Yonath,et al. Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3 , 2001, The EMBO journal.
[39] C R Hutchinson,et al. Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis. , 1999, Biochemistry.
[40] P. Freemont,et al. Crystal structure of the DNA modifying enzyme beta‐glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose. , 1994, The EMBO journal.
[41] C. Méndez,et al. Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin. , 1999, Chemistry & biology.
[42] B. Moore,et al. Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster , 2000 .
[43] W. Strohl,et al. Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5 , 1996, Journal of bacteriology.
[44] U. Sankawa,et al. Expression, Purification, and Characterization of AknX Anthrone Oxygenase, Which Is Involved in Aklavinone Biosynthesis in Streptomyces galilaeus , 2002, Journal of bacteriology.
[45] U. Sankawa,et al. Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus , 1994, Journal of bacteriology.
[46] A. Bechthold,et al. LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis , 2005, Chembiochem : a European journal of chemical biology.
[47] M. Buttner,et al. The bldC Developmental Locus of Streptomyces coelicolor Encodes a Member of a Family of Small DNA-Binding Proteins Related to the DNA-Binding Domains of the MerR Family , 2005, Journal of bacteriology.
[48] Shiou-Chuan Tsai,et al. Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity , 2004, Biochemistry.
[49] R. C. Pandey,et al. FREDERICAMYCIN A, A NEW ANTITUMOR ANTIBIOTIC , 1981 .
[50] J. Rohr,et al. The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins. , 2003, Journal of the American Chemical Society.
[51] H. H. Peter,et al. 3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. , 1994, The Journal of antibiotics.
[52] M. Skurnik,et al. Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis , 1997, Molecular and General Genetics MGG.
[53] J. Rohr,et al. Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus. , 2005, Journal of the American Chemical Society.
[54] A. Kirschning,et al. The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. , 2000, Chemistry & biology.
[55] F. Tomita,et al. Gilvocarcins, new antitumor antibiotics. 2. Structural elucidation. , 1981, The Journal of antibiotics.
[56] Chaitan Khosla,et al. Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. , 2003, Biochemistry.
[57] B. Leach,et al. Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New Species , 1953 .
[58] J. Salas. Novel mechanism for priming aromatic polyketide synthases. , 2004, Chemistry & biology.
[59] Ann M Stock,et al. Structural relationships in the OmpR family of winged-helix transcription factors. , 1997, Journal of molecular biology.
[60] B. Moore,et al. Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[61] B. Moore,et al. Engineering biodiversity with type II polyketide synthase genes , 2000, Antonie van Leeuwenhoek.
[62] S. Oka,et al. Effects of Polyphenolic Anthrone Derivatives, Resistomycin and Hypericin, on Apoptosis in Human Megakaryoblastic Leukemia CMK-7 Cell Line , 2002, Zeitschrift fur Naturforschung. C, Journal of biosciences.
[63] K. Menzel,et al. Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. , 2005, Chemistry.
[64] C. Khosla,et al. Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor. , 1994, Chemistry & biology.
[65] R. Cox,et al. MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. , 1998, Chemistry & biology.
[66] B. Wilkinson,et al. Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. , 2002, Chemistry & biology.
[67] M. Bibb,et al. Primary and secondary metabolism, and post‐translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor , 2002, Molecular microbiology.
[68] A. Bechthold,et al. It works: combinatorial biosynthesis for generating novel glycosylated compounds , 2005, Molecular microbiology.
[69] M. Bibb,et al. The regulation of antibiotic production in Streptomyces coelicolor A3(2) , 1996 .
[70] M. Morimoto,et al. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity. , 1981, The Journal of antibiotics.
[71] Blaine A. Pfeifer,et al. Biosynthesis of Polyketides in Heterologous Hosts , 2001, Microbiology and Molecular Biology Reviews.
[72] C. Méndez,et al. Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline. , 1997, Chemistry and Biology.
[73] A. H. Wang,et al. Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicity , 2005, Nucleic acids research.
[74] J. Lawrence,et al. Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5 , 1994, Journal of bacteriology.
[75] A. Bechthold,et al. Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. , 2005, Chemistry & biology.
[76] C R Hutchinson,et al. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase. , 1994, Gene.
[77] M. Buttner,et al. Different alleles of the response regulator gene bldM arrest Streptomyces coelicolor development at distinct stages , 2000, Molecular microbiology.
[78] Ho Young Lee,et al. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases , 2004 .
[79] H. Brockmann,et al. Die konstitution des resistomycins , 1968 .
[80] C. Khosla,et al. Domain Analysis of the Molecular Recognition Features of Aromatic Polyketide Synthase Subunits* , 1997, The Journal of Biological Chemistry.
[81] Taek Soon Lee,et al. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. , 2003, Biochemistry.
[82] L. Cong,et al. A gene cluster involved in nogalamycin biosynthesis fromStreptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway , 1996, Molecular and General Genetics MGG.
[83] M. Fraaije,et al. Flavoenzymes: diverse catalysts with recurrent features. , 2000, Trends in biochemical sciences.
[84] A. Lorico,et al. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. , 1993, European journal of cancer.
[85] David O'Hagan,et al. The polyketide metabolites , 1991 .
[86] A. Bechthold,et al. LanGT2 Catalyzes the First Glycosylation Step during Landomycin A Biosynthesis , 2005, Chembiochem : a European journal of chemical biology.
[87] John Crosby,et al. Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus. , 2003, Biochemistry.
[88] C. Hutchinson,et al. Biosynthetic Studies of Daunorubicin and Tetracenomycin C. , 1997, Chemical reviews.
[89] U. Rix,et al. Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. , 2004, Chemistry & biology.
[90] R. Cox,et al. Catalytic self-acylation of type II polyketide synthase acyl carrier proteins. , 1998, Chemistry & biology.
[91] J. Rohr,et al. Generation of Novel Landomycins M and O through Targeted Gene Disruption , 2005, Chembiochem : a European journal of chemical biology.
[92] J. Rohr,et al. Angucycline group antibiotics. , 1992, Natural product reports.
[93] J. Caballero,et al. Organisation and functions of the actV A region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor , 1991, Molecular and General Genetics MGG.
[94] D. Hopwood,et al. Genetic Contributions to Understanding Polyketide Synthases. , 1997, Chemical reviews.
[95] A. Bechthold,et al. Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. , 2004, FEMS microbiology letters.
[96] Xiuhua Pang,et al. Involvement of AlpV, a New Member of the Streptomyces Antibiotic Regulatory Protein Family, in Regulation of the Duplicated Type II Polyketide Synthase alp Gene Cluster in Streptomyces ambofaciens , 2005, Journal of bacteriology.
[97] Chaitan Khosla,et al. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. , 2002, Structure.
[98] M. Metsä-Ketelä,et al. Engineering Anthracycline Biosynthesis toward Angucyclines , 2003, Antimicrobial Agents and Chemotherapy.
[99] K. Chater,et al. Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2) , 1993, Journal of bacteriology.
[100] L. Vining,et al. Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230. , 1994, Microbiology.
[101] S. Jensen,et al. The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant. , 2002, Microbiology.
[102] J R Jacobsen,et al. Tolerance and specificity of polyketide synthases. , 1999, Annual review of biochemistry.
[103] A. Imberty,et al. T4 phage beta-glucosyltransferase: substrate binding and proposed catalytic mechanism. , 1999, Journal of molecular biology.
[104] M. Bibb,et al. Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant , 1995, Journal of bacteriology.
[105] J. Rohr,et al. Function of lanGT3, a Glycosyltransferase Gene Involved in Landomycin A Biosynthesis , 2004, Chembiochem : a European journal of chemical biology.
[106] L. Vining,et al. Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2 , 1995, Journal of bacteriology.
[107] M. Austin,et al. Structural control of polyketide formation in plant-specific polyketide synthases. , 2000, Chemistry & biology.
[108] A. Bechthold,et al. Genes and enzymes involved in deoxysugar biosynthesis in bacteria. , 1999, Natural product reports.
[109] J. Caballero,et al. The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces , 1991, Cell.
[110] D. Hopwood,et al. Identification of a novel shunt product produced by a disruptant of the actVI-ORFA gene involved in the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2) , 2000 .
[111] U. Rix,et al. Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone. , 2005, The Journal of organic chemistry.
[112] C. Méndez,et al. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. , 1996, Gene.
[113] C. Hutchinson,et al. The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene. , 2000, Microbiology.
[114] U. Rix,et al. The Oxidative Ring Cleavage in Jadomycin Biosynthesis: A Multistep Oxygenation Cascade in a Biosynthetic Black Box , 2005, Chembiochem : a European journal of chemical biology.
[115] D. Hopwood,et al. Functional Complementation of Pyran Ring Formation in Actinorhodin Biosynthesis in Streptomyces coelicolorA3(2) by Ketoreductase Genes for Granaticin Biosynthesis , 2001, Journal of bacteriology.
[116] K. Liedl,et al. Daunomycin Intercalation Stabilizes Distinct Backbone Conformations of DNA , 2004, Journal of biomolecular structure & dynamics.
[117] M. Bibb,et al. The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation , 1997, Journal of bacteriology.
[118] K. Reynolds,et al. Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis , 1998 .
[119] L. Vining,et al. A repressor-response regulator gene pair controlling jadomycin B production in Streptomyces venezuelae ISP5230. , 2001, Gene.
[120] D. Hoffmeister,et al. Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. , 2003, FEMS microbiology letters.
[121] Katalin F Medzihradszky,et al. An antibiotic factory caught in action , 2004, Nature Structural &Molecular Biology.
[122] T. Aoyagi,et al. Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. , 1992, Journal of antibiotics (Tokyo. 1968).
[123] B. Moore,et al. EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[124] R. Weiss. The anthracyclines: will we ever find a better doxorubicin? , 1992, Seminars in oncology.
[125] B. Moore,et al. A Plant-like Biosynthesis of Benzoyl-CoA in the Marine Bacterium ‘Streptomyces maritimus’ , 2000 .
[126] Yong Huang,et al. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. , 2005, Journal of the American Chemical Society.
[127] Wei Lu,et al. Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[128] S. Cohen,et al. Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. , 2001, Genes & development.
[129] A. Hizi,et al. Structural and Biosynthetic Investigations of the Rubromycins , 2000 .
[130] John Crosby,et al. The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding. , 2004, Structure.
[131] J. Thorson,et al. The hedamycin locus implicates a novel aromatic PKS priming mechanism. , 2004, Chemistry & biology.
[132] Taek Soon Lee,et al. Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases , 2004, PLoS biology.
[133] H. Zähner,et al. Stoffwechselprodukte von Actinomyceten, XVI. Cinerubine , 1959 .
[134] B. Rawlings. Biosynthesis of fatty acids and related metabolites. , 1997, Natural product reports.
[135] J. Clardy,et al. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. , 1981, The Journal of antibiotics.
[136] W. Strohl,et al. Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis , 1997, Journal of bacteriology.
[137] J. Rohr,et al. Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics. , 2001, Chemistry & biology.
[138] N. Priestley,et al. Purification, Properties, and Characterization of Recombinant Streptomyces sp. Strain C5 DoxA, a Cytochrome P-450 Catalyzing Multiple Steps in Doxorubicin Biosynthesis , 1999, Journal of bacteriology.
[139] Gunter Schneider,et al. Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation , 2004, The EMBO journal.
[140] H. Ikeda,et al. Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain , 1986, Antimicrobial Agents and Chemotherapy.
[141] M. Fernández-Moreno,et al. Characterization of the Pathway-Specific Positive Transcriptional Regulator for Actinorhodin Biosynthesis inStreptomyces coelicolor A3(2) as a DNA-Binding Protein , 1999, Journal of bacteriology.
[142] H. Baylis,et al. Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2). , 1987, Genes & development.
[143] Jon S. Thorson,et al. Glycosylated Natural Products , 2005 .
[144] H. Floss,et al. Identification of four genes from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22 involved in the biosynthesis of L-rhodinose. , 2001, The Journal of antibiotics.
[145] B. Moore,et al. Mutasynthesis of enterocin and wailupemycin analogues. , 2003, Journal of the American Chemical Society.
[146] A. Bechthold,et al. Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. , 2004, The Journal of antibiotics.
[147] P. Leadlay,et al. A chain initiation factor common to both modular and aromatic polyketide synthases , 1999, Nature.
[148] P. Bartel,et al. Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions , 1990, Journal of bacteriology.
[149] C. Khosla,et al. Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes , 2000 .
[150] F Wright,et al. Codon usage in the G+C-rich Streptomyces genome. , 1992, Gene.
[151] D. Hopwood,et al. Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme , 1997, Journal of bacteriology.
[152] U. Rix,et al. Urdamycin L: A Novel Metabolic Shunt Product that Provides Evidence for the Role of the urdM Gene in the Urdamycin A Biosynthetic Pathway of Streptomyces fradiae TÜ 2717 , 2003, Chembiochem : a European journal of chemical biology.
[153] B J Rawlings,et al. Type I polyketide biosynthesis in bacteria (part B). , 2001, Natural product reports.
[154] Modification of post-PKS tailoring steps through combinatorial biosynthesis. , 2002, Natural product reports.
[155] L. Peterson. Antimicrobial activity and pharmacokinetics/pharmacodynamics of the novel glycylcycline, tigecycline. , 2005, Diagnostic microbiology and infectious disease.
[156] U. Rix,et al. Function of glycosyltransferase genes involved in urdamycin A biosynthesis. , 2000, Chemistry & biology.
[157] Yoshiyuki Sakaki,et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[158] C. Khosla,et al. Cloning, Nucleotide Sequence, and Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-steroidal Estrogen Receptor Antagonist , 2000, The Journal of Biological Chemistry.
[159] G. Schneider. Enzymes in the biosynthesis of aromatic polyketide antibiotics. , 2005, Current opinion in structural biology.
[160] Gunter Schneider,et al. Crystal Structure of a Ternary Complex of DnrK, a Methyltransferase in Daunorubicin Biosynthesis, with Bound Products* , 2004, Journal of Biological Chemistry.
[161] B. Moore,et al. A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β‐Oxidation , 2001, Chembiochem : a European journal of chemical biology.
[162] J. Rohr,et al. The Biosynthesis of Aureolic Acid Group Antibiotics , 1999 .
[163] C. Dempsey,et al. Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). , 1997, Biochemistry.
[164] J. Rohr,et al. The structure of tetracenomycin C. , 1992, Journal of antibiotics (Tokyo. 1968).
[165] J. Westpheling,et al. The bldB Gene Encodes a Small Protein Required for Morphogenesis, Antibiotic Production, and Catabolite Control inStreptomyces coelicolor , 1998, Journal of bacteriology.
[166] C. Hertweck,et al. Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. , 2004, Organic & biomolecular chemistry.
[167] C Hertweck,et al. Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. , 2000, Chemistry & biology.
[168] A. Faworsky. Ueber Isomerisationserscheinungen in den Reihen der Carbonylverbindungen gechlorter Alkohole und haloïdsubstituirter Oxyde der Aethylenkohlen‐wasserstoffe , 1895 .
[169] D. Hoffmeister,et al. Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. , 2001, Chemistry & biology.
[170] U. Rix,et al. Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. , 2002, Journal of the American Chemical Society.
[171] P. Taylor,et al. Structures of redox enzymes. , 2000, Current opinion in biotechnology.
[172] H. Decker,et al. Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation , 1995, Journal of bacteriology.
[173] J. Sun,et al. Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII‐ORF4 transcription and actinorhodin biosynthesis , 2001, Molecular microbiology.
[174] B. Shen. Biosynthesis of Aromatic Polyketides , 2000 .
[175] J. Portugal,et al. Map of chartreusin and elsamicin binding sites on DNA , 1991, FEBS letters.
[176] B J Rawlings,et al. Biosynthesis of polyketides (other than actinomycete macrolides). , 1999, Natural product reports.
[177] G. Schneider,et al. Crystal structure of β‐ketoacyl‐acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes , 1998, The EMBO journal.
[178] C. Khosla,et al. Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase , 1994 .
[179] U. Rix,et al. Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase* , 2005, Journal of Biological Chemistry.
[180] A. Baeyer,et al. Einwirkung des Caro'schen Reagens auf Ketone , 1899 .
[181] S. Walker,et al. Remarkable structural similarities between diverse glycosyltransferases. , 2002, Chemistry & biology.
[182] B. Shen,et al. Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[183] C. Reeves. The Enzymology of Combinatorial Biosynthesis , 2003, Critical reviews in biotechnology.
[184] K. Ramos,et al. Landomycin A inhibits DNA synthesis and G1/S cell cycle progression. , 1999, Bioorganic & medicinal chemistry letters.
[185] J. Rohr,et al. Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A-D. , 1990, The Journal of antibiotics.
[186] P. Mäntsälä,et al. A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin , 2000, Molecular and General Genetics MGG.
[187] Yoshiyuki Sakaki,et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis , 2003, Nature Biotechnology.
[188] B. Ostash,et al. Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon. , 2006, FEMS microbiology letters.
[189] K. Klika,et al. Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants. , 1999, Bioorganic & medicinal chemistry letters.
[190] C R Hutchinson,et al. Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides. , 1997, Chemistry & biology.
[191] S Omura,et al. Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. , 1994, Gene.
[192] B. Shen,et al. Cloning, Sequencing, and Heterologous Expression of the elmGHIJ Genes Involved in the Biosynthesis of the Polyketide Antibiotic Elloramycin from Streptomyces olivaceus Tü2353 , 2001 .
[193] R. Losick,et al. An oligopeptide permease responsible for the import of an extracellular signal governing aerial mycelium formation in Streptomyces coelicolor , 1996, Molecular microbiology.
[194] C. Hutchinson,et al. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius , 1992, Journal of bacteriology.
[195] B. Rawlings. Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis). , 2001, Natural product reports.
[196] C. Méndez,et al. Genetic Organization of the Biosynthetic Gene Cluster for the Antitumor Angucycline Oviedomycin in Streptomyces antibioticus ATCC 11891 , 2004, Chembiochem : a European journal of chemical biology.
[197] K. Chater,et al. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[198] J. Rohr,et al. Oxidative rearrangement processes in the biosynthesis of gilvocarcin V. , 2004, Journal of the American Chemical Society.
[199] H. Petković,et al. Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths. , 1999, The Journal of biological chemistry.
[200] Bradley S Moore,et al. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. , 2002, Natural product reports.
[201] M. Okuhara,et al. R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination. , 1993, The Journal of antibiotics.
[202] C. Khosla,et al. In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase. , 2001, Biochemistry.
[203] J. Hakala,et al. Studies on a second and third ring cyclization in anthracycline biosynthesis. , 2003, Journal of antibiotics (Tokyo. 1968).
[204] R. Shafer,et al. The three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: evidence for an interaction between the E saccharides. , 2000, Biopolymers.
[205] D. Kang,et al. The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus , 2001, Journal of Industrial Microbiology and Biotechnology.
[206] F. Zunino,et al. Role of the sugar moiety in the pharmacological activity of anthracyclines: development of a novel series of disaccharide analogs. , 2001, Biochemical pharmacology.
[207] H. Imanaka,et al. Enterocin, a new antibiotic taxonomy, isolation and characterization. , 1976, The Journal of antibiotics.
[208] K. Chater,et al. Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered. , 1985, The EMBO journal.
[209] L. Vining,et al. Functional Characterization of the jadI Gene As a Cyclase Forming Angucyclinones , 1999 .
[210] C. Hutchinson,et al. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis , 1996, Journal of bacteriology.
[211] C. Khosla,et al. Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities , 1993 .
[212] J. Staunton,et al. Polyketide biosynthesis: a millennium review. , 2001, Natural product reports.
[213] L. Vining,et al. Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae ISP5230 by jadW(1), a member of the afsA family of gamma-butyrolactone regulatory genes. , 2003, Microbiology.
[214] E. Ragg,et al. 31P NMR study of daunorubicin‐d(CGTACG) complex in solution Evidence of the intercalation sites , 1988, FEBS letters.
[215] P. Thibault,et al. Jadomycin, a novel 8H-benz[b]oxazolo[3,2-f]phenanthridine antibiotic from from streptomyces venezuelae ISP5230.☆ , 1991 .
[216] B. Moore,et al. Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. , 2004, Chemistry & biology.
[217] P. Mäntsälä,et al. The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures , 2001, Molecular Genetics and Genomics.
[218] J. Rohr,et al. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. , 2004, Chemistry & biology.
[219] H. Kawaguchi,et al. Elsamicins, new antitumor antibiotics related to chartreusin. I. Production, isolation, characterization and antitumor activity. , 1986, The Journal of antibiotics.
[220] Y. Lindqvist,et al. The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes. , 2001, Journal of molecular biology.
[221] D. Hopwood,et al. Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis. , 1999, FEMS microbiology letters.
[222] C. Richard Hutchinson,et al. The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide , 1999, Journal of bacteriology.
[223] Tsuneyuki Nakamura,et al. Apoptosis in Young Rats with Adriamycin-Induced Cardiomyopathy—Comparison with Pirarubicin, a New Anthracycline Derivative , 2002, Pediatric Research.
[224] H. Schmid,et al. Über die Struktur des Chartreusins I , 1964 .
[225] C. Hutchinson,et al. The Streptomyces glaucescens TcmR protein represses transcription of the divergently oriented tcmR and tcmA genes by binding to an intergenic operator region , 1992, Journal of bacteriology.
[226] J. Carver,et al. Structural investigation of the hedamycin:d(ACCGGT)2 complex by NMR and restrained molecular dynamics. , 2002, Biochemical and biophysical research communications.
[227] Marilyn Roberts,et al. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance , 2001, Microbiology and Molecular Biology Reviews.
[228] J. Nodwell,et al. Biochemical Activities of the absA Two-Component System of Streptomyces coelicolor , 2005, Journal of bacteriology.
[229] J. Rohr,et al. Metabolic products of microorganisms. 240. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. II. Structural studies of urdamycins B to F. , 1987, The Journal of antibiotics.
[230] M. Buttner,et al. ςBldN, an Extracytoplasmic Function RNA Polymerase Sigma Factor Required for Aerial Mycelium Formation in Streptomyces coelicolor A3(2) , 2000, Journal of bacteriology.
[231] B. Gatto,et al. Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar. , 1997, Biochemistry.
[232] Björn Sohlberg,et al. Cross‐regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor , 2005, Molecular microbiology.
[233] Y. Tokuma,et al. Structure of enterocin; X-ray analysis of m-Bromobenzoyl enterocin dihydrate. , 1976, The Journal of antibiotics.
[234] M. Bibb,et al. Regulation of secondary metabolism in streptomycetes. , 2005, Current opinion in microbiology.
[235] Wei Lu,et al. AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. , 2004, Biochemistry.
[236] C. Hutchinson,et al. Mapping the DNA‐binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI , 2002, Molecular microbiology.
[237] Marco W. Fraaije,et al. Baeyer-Villiger monooxygenases, an emerging family of flavin-dependent biocatalysts , 2003 .
[238] P. Mäntsälä,et al. Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater , 2000, Antimicrobial Agents and Chemotherapy.
[239] C. Hutchinson,et al. Daunorubicin type II polyketide synthase enzymes DpsA and DpsB determine neither the choice of starter unit nor the cyclization pattern of aromatic polyketides , 1995 .
[240] H. Kawaguchi,et al. The structure of pradimicins A, B and C: a novel family of antifungal antibiotics , 1989 .
[241] C. Walsh,et al. AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. , 2005, Chemistry & biology.
[242] H. Seto,et al. Utilization of13C-13C coupling in structural and biosynthetic studies. VII1) the structure and biosynthesis of vulgamycin. , 1976 .
[243] C. Hertweck,et al. Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide. , 2005, Chemistry & biology.
[244] J. Rohr,et al. Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717. , 2000, Microbiology.
[245] G. Schneider,et al. Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. , 2003, Journal of molecular biology.
[246] S. Baumberg,et al. Transcriptional activation of the pathway‐specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor , 2005, Molecular microbiology.
[247] A. Miele,et al. The structure of ActVA‐Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis , 2003, The EMBO journal.
[248] Ann M Stock,et al. The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor. , 1997, Structure.
[249] G. Schneider,et al. Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens. , 2003, Acta crystallographica. Section D, Biological crystallography.
[250] G. Schneider,et al. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. , 2006, Journal of molecular biology.
[251] H. Laatsch,et al. Resomycins A-C : New Anthracyclinone Antibiotics Formed by a Terrestrial Streptomyces sp. , 2003 .
[252] L. Gianni,et al. Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity , 2004, Pharmacological Reviews.
[253] M. Bibb,et al. Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production inStreptomyces coelicolor A3(2)* , 2000, The Journal of Biological Chemistry.
[254] C. Walsh,et al. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. , 2001, Structure.
[255] M. Bibb,et al. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR‐like DNA‐binding fold , 1997, Molecular microbiology.