LEUKEMOID REACTIONS TO TUBERCULOSIS.

TUBERCULOSIS has been associated with a variety of hematological abnormalities. These include hypoplasia of the bone marrow, 1,2 myelofibrosis, 3-5 and polycythemia. 6 Tuberculosis is sometimes associated with a leukemoid reaction which must be differentiated from leukemia. In 1911 Coley and Ewing, 7 from postmortem studies, first drew attention to the leukemoid response which may be evoked by tuberculosis. The association was first made antemortem by Mills and Townsend 8 in 1937. We have found only 38 reports of patients who had leukemoid reactions to tuberculosis which fulfilled the following criteria: (1) tubercle bacilli had to be demonstrated and (2) an excessive leukocytosis or an abnormal shift towards immaturity in the peripheral blood or in the bone marrow. A diagnosis of leukemia was considered to be excluded if a lasting hematologic recovery occurred or if visceral infiltration with leukocytes could not be demonstrated at autopsy. It is the purpose of this paper to discuss

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