Placental transmission of atropine at full-term pregnancy.

Measurements of placental transmission of atropine were performed during Caesarean section. Twenty-five patients received 3H-atropine 0.5 microgram . kg-1 i.v. 1-30 min before delivery. Maternal venous blood was sampled before the induction of anaesthesia and at the moment of delivery, together with umbilical arterial and venous blood. Total hydrogen-3 activity was determined by liquid scintillation counting. The stability of 3H-atropine was confirmed by paper chromatography. The concentrations in the umbilical vein 1 and 5 min after injection were respectively 12% and 93% of the corresponding maternal value. Those in the umbilical artery were approximately 50% of those in the umbilical vein during the same period.

[1]  S. Kalser,et al.  THE FATE OF ATROPINE IN MAN * , 1971 .

[2]  E. Hirvonen,et al.  VALUE OF THE INTRAVENOUS ATROPINE TEST AS A CRITERION OF PLACENTAL FUNCTION. , 1965, The Journal of obstetrics and gynaecology of the British Commonwealth.

[3]  J. H. Wills,et al.  THE FATE OF ATROPINE IN MAN , 1962 .

[4]  V. Politi,et al.  Resuscitation of the newborn , 1957, Canadian Anaesthetists' Society journal.

[5]  G. Brunel,et al.  The Value of the Atropine Test in Therapeutic Orientation during Feto-Placental Insufficiency , 1975 .

[6]  S. Saarikoski.  Fate of noradrenaline in the human foetoplacental unit. , 1974, Acta physiologica Scandinavica. Supplementum.

[7]  R. Richterich.  Klinische Chemie : Theorie und Praxis , 1971 .

[8]  S. Saarikoski,et al.  Quantitative measurements of placental transfer and distribution of radioactive atropine in fetus. , 1970, Annales chirurgiae et gynaecologiae Fenniae.

[9]  A. John.  PLACENTAL TRANSFER OF ATROPINE AND THE EFFECT ON FOETAL HEART RATE. , 1965, British journal of anaesthesia.

[10]  K. Soiva,et al.  Phonocardiographic studies of the foetal heart rate. , 1959, Annales chirurgiae et gynaecologiae Fenniae.