CIRP Annals - Manufacturing Technology

A B S T R A C T Biomanufacturing integrates life science and engineering fundamentals to produce biocompatible products enhancing the quality of life. The state-of-the-art of this rapidly evolving manufacturing sector is presented and discussed, in particular the additive electrical, chemical and physical processes currently being applied to produce synthetic and biological parts. This fabrication strategy is strongly materialdependent, so the main classes of biomaterials are detailed. It is explained the potential to process composite materials combining synthetic and biological materials, such as cells, proteins and growth factors, as well the interdependences between materials and processes. The techniques commonly used to increase the bioactivity of clinical implants and improve the interface characteristics between biological tissues and implants are also presented. 2012 CIRP.

[1]  Tien-Min G. Chu,et al.  CT-generated porous hydroxyapatite orbital floor prosthesis as a prototype bioimplant. , 1997, AJNR. American journal of neuroradiology.

[2]  Joseph Jagur-Grodzinski,et al.  Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies , 2006 .

[3]  M. Leu,et al.  Fabrication of 13-93 bioactive glass scaffolds for bone tissue engineering using indirect selective laser sintering , 2011, Biofabrication.

[4]  L. Silvio,et al.  Porosity variation in hydroxyapatite and osteoblast morphology: a scanning electron microscopy study , 2004, Journal of microscopy.

[5]  Scott J. Hollister,et al.  Computational Design, Freeform Fabrication and Testing of Nylon-6 Tissue Engineering Scaffolds , 2002 .

[6]  Vladimir Mironov,et al.  Organ printing: tissue spheroids as building blocks. , 2009, Biomaterials.

[7]  T. Boland,et al.  Inkjet printing of viable mammalian cells. , 2005, Biomaterials.

[8]  Antonios G Mikos,et al.  In vitro degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds. , 2005, Biomaterials.

[9]  Jean-Pierre Kruth,et al.  Direct Digital Manufacturing of Complex Dental Prostheses , 2008 .

[10]  T. Goswami,et al.  Knee implants – Review of models and biomechanics , 2009 .

[11]  Lyndon F Cooper,et al.  The effects of implant surface nanoscale features on osteoblast-specific gene expression. , 2009, Biomaterials.

[12]  Delbert E. Day,et al.  Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair , 2011, Journal of materials science. Materials in medicine.

[13]  Christopher J. Sutcliffe,et al.  Selective laser melting of high aspect ratio 3D nickel–titanium structures two way trained for MEMS applications , 2008 .

[14]  Michael T. Wilson,et al.  Antibacterial activity of particulate bioglass against supra- and subgingival bacteria. , 2001, Biomaterials.

[15]  David J Mooney,et al.  Cell instructive polymers. , 2006, Advances in biochemical engineering/biotechnology.

[16]  D. Puleo,et al.  A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy. , 2002, Biomaterials.

[17]  Kornel Ehmann,et al.  A CAD approach to helical groove machining—I. mathematical model and model solution , 1996 .

[18]  Seung Jin Lee,et al.  Electrospinning of polysaccharides for regenerative medicine. , 2009, Advanced drug delivery reviews.

[19]  Xingdong Zhang,et al.  Gene expressions of Collagen type I, ALP and BMP-4 in osteo-inductive BCP implants show similar pattern to that of natural healing bones , 2009 .

[20]  K-Y Lee,et al.  Ceramic bioactivity: progresses, challenges and perspectives , 2006, Biomedical materials.

[21]  L. Gibson,et al.  The effect of pore size on cell adhesion in collagen-GAG scaffolds. , 2005, Biomaterials.

[22]  Lorenzo Moroni,et al.  Polymer hollow fiber three-dimensional matrices with controllable cavity and shell thickness. , 2006, Biomaterials.

[23]  David H. Kohn,et al.  Metals in medical applications , 1998 .

[24]  M. Meyers,et al.  Biomedical applications of titanium and its alloys , 2008 .

[25]  W. Huang,et al.  Stimulus-responsive shape memory materials: A review , 2012 .

[26]  S. Ramakrishna,et al.  A review on electrospinning design and nanofibre assemblies , 2006, Nanotechnology.

[27]  A. Kneissl,et al.  Generation, development and degradation of the intrinsic two-way shape memory effect in different alloy systems , 2002 .

[28]  Antonio Scarano,et al.  Inflammatory infiltrate, microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri-implant soft tissues around titanium and zirconium oxide healing caps. , 2006, Journal of periodontology.

[29]  Stephen Malkin,et al.  CAD/CAM for Geometry and Process Analysis of Helical Groove Machining , 1990 .

[30]  Richard M Day,et al.  Bioactive glass stimulates the secretion of angiogenic growth factors and angiogenesis in vitro. , 2005, Tissue engineering.

[31]  Christopher J. Sutcliffe,et al.  Gas flow effects on selective laser melting (SLM) manufacturing performance , 2012 .

[32]  Juan Pou,et al.  Three-dimensional laser-assisted processing of bioceramics , 2010 .

[33]  David G Simpson,et al.  Nanofiber technology: designing the next generation of tissue engineering scaffolds. , 2007, Advanced drug delivery reviews.

[34]  Dietmar Werner Hutmacher,et al.  Composite electrospun scaffolds for engineering tubular bone grafts. , 2009, Tissue engineering. Part A.

[35]  Ning Liu,et al.  Development of highly porous titanium scaffolds by selective laser melting , 2010 .

[36]  Kyriacos A. Athanasiou,et al.  Elevated temperature degradation of a 50: 50 copolymer of PLA-PGA , 1997 .

[37]  I. Denry,et al.  State of the art of zirconia for dental applications. , 2008, Dental materials : official publication of the Academy of Dental Materials.

[38]  J. Cesarano,et al.  ROBOCASTING PROVIDES MOLDLESS FABRICATION FROM SLURRY DEPOSITION , 1998 .

[39]  L G Griffith,et al.  Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. , 2001, Tissue engineering.

[40]  K. Leong,et al.  Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends. , 2003, Biomaterials.

[41]  Horst A von Recum,et al.  Electrospinning: applications in drug delivery and tissue engineering. , 2008, Biomaterials.

[42]  Paulo Jorge Da Silva bartolo,et al.  Advanced Processes to Fabricate Scaffolds for Tissue Engineering , 2008 .

[43]  Joel W. Barlow,et al.  Selective Laser Sintering of Bioceramic Materials for Implants , 1993 .

[44]  M. Elahinia,et al.  Manufacturing and processing of NiTi implants: A review , 2012 .

[45]  D. Hukins,et al.  Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material. , 2009, Medical engineering & physics.

[46]  D. Hutmacher,et al.  The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. , 2009, Biomaterials.

[47]  S. Hollister,et al.  Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. , 2002, Biomaterials.

[48]  J. Kruth,et al.  Selective laser melting of biocompatible metals for rapid manufacturing of medical parts , 2006 .

[49]  Thomas Imwinkelried,et al.  Mechanical properties of open-pore titanium foam. , 2007, Journal of biomedical materials research. Part A.

[50]  Igor Smurov,et al.  Surface Morphology in Selective Laser Melting of Metal Powders , 2011 .

[51]  Jeroen Rouwkema,et al.  Vascularization in tissue engineering. , 2008, Trends in biotechnology.

[52]  Colleen L Flanagan,et al.  Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. , 2005, Biomaterials.

[53]  Krishna C. R. Kolan,et al.  Selective laser sintering of 13-93 bioactive glass , 2011 .

[54]  Jan Bültmann,et al.  Design of an Optical system for the In Situ Process Monitoring of Selective Laser Melting (SLM) , 2011 .

[55]  Annie M Jones,et al.  Hydrogel dressings in the management of a variety of wound types: A review , 2005 .

[56]  Ivan P. Parkin,et al.  Porous biocompatible implants and tissue scaffolds synthesized by selective laser sintering from Ti and NiTi , 2008 .

[57]  Martin Möller,et al.  Electrospinning of polymer melts: Phenomenological observations , 2007 .

[58]  Torsten Blunk,et al.  Does UV irradiation affect polymer properties relevant to tissue engineering , 2001 .

[59]  M. Kotaki,et al.  A review on polymer nanofibers by electrospinning and their applications in nanocomposites , 2003 .

[60]  Q. Meng,et al.  A review of shape memory polymer composites and blends , 2009 .

[61]  Federica Chiellini,et al.  Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion – Part 2: Influence of pore size and geometry , 2011 .

[62]  Ryan B. Wicker,et al.  Stereolithography of Three-Dimensional Bioactive Poly(Ethylene Glycol) Constructs with Encapsulated Cells , 2006, Annals of Biomedical Engineering.

[63]  Dietmar W. Hutmacher,et al.  Comparison of the degradation of polycaprolactone and polycaprolactone–(β‐tricalcium phosphate) scaffolds in alkaline medium , 2007 .

[64]  Daniel D. Frey,et al.  Swept Envelopes of Cutting Tools in Integrated Machine and Workpiece Error Budgeting , 1997 .

[65]  Liang Hao,et al.  Customised Implants for Bone Replacement and Growth , 2008 .

[66]  Richard A Black,et al.  Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds. , 2007, Biomaterials.

[67]  Ian M. Hutchings,et al.  Direct Writing Technology Advances and Developments , 2008 .

[68]  A Lode,et al.  Calcium phosphate bone cements, functionalized with VEGF: release kinetics and biological activity. , 2007, Journal of biomedical materials research. Part A.

[69]  S. Shabalovskaya,et al.  Mechanical properties and shape memory of porous nitinol , 1994 .

[70]  Antonio Carrassi,et al.  Bacterial colonization of zirconia ceramic surfaces: an in vitro and in vivo study. , 2002, The International journal of oral & maxillofacial implants.

[71]  Min Wang,et al.  Selective laser sintering of porous tissue engineering scaffolds from poly(l-lactide)/carbonated hydroxyapatite nanocomposite microspheres , 2008, Journal of materials science. Materials in medicine.

[72]  T. Boland,et al.  Human microvasculature fabrication using thermal inkjet printing technology. , 2009, Biomaterials.

[73]  Joaquim Ciurana,et al.  BioCell Printing: Integrated automated assembly system for tissue engineering constructs , 2011 .

[74]  Dong-Woo Cho,et al.  Development of a bone scaffold using HA nanopowder and micro-stereolithography technology , 2007 .

[75]  Dong-Woo Cho,et al.  Development of nano- and microscale composite 3D scaffolds using PPF/DEF-HA and micro-stereolithography , 2009 .

[76]  Young-Hag Koh,et al.  Fabrication of poly(ε-caprolactone)/hydroxyapatite scaffold using rapid direct deposition , 2006 .

[77]  K W Dalgarno,et al.  Indirect selective laser sintering of apatite—wollostonite glass—ceramic , 2008, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[78]  Joseph Jagur-Grodzinski,et al.  Polymeric gels and hydrogels for biomedical and pharmaceutical applications , 2010 .

[79]  P. Bártolo,et al.  Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly(ε‐caprolactone) scaffolds , 2012 .

[80]  Chee Kai Chua,et al.  Editorial: Celebrating the 70th Anniversary of Professor Yongnian Yan: A life dedicated to science and technology , 2008 .

[81]  Stephen F Badylak,et al.  An overview of tissue and whole organ decellularization processes. , 2011, Biomaterials.

[82]  Dietmar W. Hutmacher,et al.  Design, Fabrication and Physical Characterization of Scaffolds Made from Biodegradable Synthetic Polymers in combination with RP Systems based on Melt Extrusion , 2008 .

[83]  M. Colina,et al.  DNA deposition through laser induced forward transfer. , 2005, Biosensors & bioelectronics.

[84]  Chad Johnson,et al.  The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. , 2004, Biomaterials.

[85]  R. Hague,et al.  Laser sintering of polyamides and other polymers , 2012 .

[86]  K. Jurczyk,et al.  Synthesis and characterization of titanium-45S5 Bioglass nanocomposites , 2011 .

[87]  Donald O Freytes,et al.  Reprint of: Extracellular matrix as a biological scaffold material: Structure and function. , 2015, Acta biomaterialia.

[88]  Federica Chiellini,et al.  Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering , 2011, Materials.

[89]  S J Bryant,et al.  The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels. , 2001, Biomaterials.

[90]  Dong-Yol Yang,et al.  Recent developments in the use of two‐photon polymerization in precise 2D and 3D microfabrications , 2006 .

[91]  Takashi Nakamura,et al.  Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments. , 2011, Acta biomaterialia.

[92]  Larry L. Hench,et al.  An Introduction to Bioceramics , 2013 .

[93]  Carlos M Mery,et al.  Biomaterials: a primer for surgeons. , 2006, Seminars in pediatric surgery.

[94]  Buddy D. Ratner,et al.  Biomaterials Science: An Introduction to Materials in Medicine , 1996 .

[95]  Geoffrey R. Mitchell,et al.  Stereo‐thermal‐lithography: a new principle for rapid prototyping , 2003 .

[96]  A.C.W. Lau,et al.  Precision extruding deposition and characterization of cellular poly‐ε‐caprolactone tissue scaffolds , 2004 .

[97]  P. Bártolo,et al.  Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion. Part 1: Influence of the degradation environment , 2010 .

[98]  K. Shakesheff,et al.  Polymer carriers for drug delivery in tissue engineering. , 2007, Advanced drug delivery reviews.

[99]  V. Mironov,et al.  Designer ‘blueprint’ for vascular trees: morphology evolution of vascular tissue constructs , 2009 .

[100]  R Z LeGeros,et al.  Biodegradation and bioresorption of calcium phosphate ceramics. , 1993, Clinical materials.

[101]  Eduardo Saiz,et al.  Direct ink writing of highly porous and strong glass scaffolds for load-bearing bone defects repair and regeneration. , 2011, Acta biomaterialia.

[102]  G. Goch,et al.  The Design and Manufacture of Biomedical Surfaces , 2007 .

[103]  Seok Won Lee,et al.  Complete swept volume generation, Part I: Swept volume of a piecewise C1-continuous cutter at five-axis milling via Gauss map , 2011, Comput. Aided Des..

[104]  Yunzhi Yang,et al.  A review on calcium phosphate coatings produced using a sputtering process--an alternative to plasma spraying. , 2005, Biomaterials.

[105]  John W. Halloran,et al.  Freeform Fabrication of Ceramics via Stereolithography , 2005 .

[106]  Yves Bellouard,et al.  Shape memory alloys for microsystems: A review from a material research perspective , 2008 .

[107]  Buddy D Ratner,et al.  Biomaterials: where we have been and where we are going. , 2004, Annual review of biomedical engineering.

[108]  N. Kotov,et al.  Three-dimensional cell culture matrices: state of the art. , 2008, Tissue engineering. Part B, Reviews.

[109]  D. Kemmoku,et al.  Use of BioCAD in the development of a growth compliant prosthetic device for cranioplasty of growing patients , 2009 .

[110]  Vladimir Mironov,et al.  Organ printing: computer-aided jet-based 3D tissue engineering. , 2003, Trends in biotechnology.

[111]  L. Murr,et al.  Microstructure and mechanical properties of open-cellular biomaterials prototypes for total knee replacement implants fabricated by electron beam melting. , 2011, Journal of the mechanical behavior of biomedical materials.

[112]  Ioannis S. Chronakis,et al.  Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process—A review , 2005 .

[113]  K W Dalgarno,et al.  Indirect selective laser sintering of an apatite-mullite glass-ceramic for potential use in bone replacement applications , 2004, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[114]  M. von Walter,et al.  Structural, mechanical and in vitro characterization of individually structured Ti-6Al-4V produced by direct laser forming. , 2006, Biomaterials.

[115]  Joseph Cesarano,et al.  Colloidal inks for directed assembly of 3-D periodic structures , 2002 .

[116]  Xiabin Jing,et al.  Biodegradable synthetic polymers: Preparation, functionalization and biomedical application , 2012 .

[117]  Bernhard Karpuschewski,et al.  Automatic search for wheel position in flute grinding of cutting tools , 2011 .

[118]  O. Harrysson,et al.  Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology , 2008 .

[119]  Elena P Ivanova,et al.  Plasma-assisted surface modification of organic biopolymers to prevent bacterial attachment. , 2011, Acta biomaterialia.

[120]  Dietmar Werner Hutmacher,et al.  State of the art and future directions of scaffold‐based bone engineering from a biomaterials perspective , 2007, Journal of tissue engineering and regenerative medicine.

[121]  Levi A. Gheber,et al.  Microgel electrospinning: A novel tool for the fabrication of nanocomposite fibers , 2009 .

[122]  Jiawei Wang,et al.  Proliferation and differentiation of osteoblast-like MC3T3-E1 cells on biomimetically and electrolytically deposited calcium phosphate coatings. , 2009, Journal of biomedical materials research. Part A.

[123]  Martine Wevers,et al.  The combined use of micro-CT imaging, in-situ loading and non-rigid image registration for 3D experimental local strain mapping on porous bone tissue engineering scaffolds under compressive loading , 2010 .

[124]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[125]  S. Kaldor,et al.  On the CAD of Profiles for Cutters and Helical Flutes - Geometrical Aspects , 1988 .

[126]  Junying Chen,et al.  Plasma-surface modification of biomaterials , 2002 .

[127]  Kornel Ehmann,et al.  A CAD approach to helical groove machining. Part 2 :Numerical evaluation and sensitivity analysis , 1997 .

[128]  J. Lewis.  Colloidal Processing of Ceramics , 2004 .

[129]  Michele Germani,et al.  Direct fabrication through electron beam melting technology of custom cranial implants designed in a PHANToM-based haptic environment , 2009 .

[130]  A. Mikos,et al.  In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. , 1999, Journal of biomedical materials research.

[131]  J M García-Aznar,et al.  On scaffold designing for bone regeneration: A computational multiscale approach. , 2009, Acta biomaterialia.

[132]  S. E. Feinberg,et al.  Hydroxyapatite implants with designed internal architecture , 2001, Journal of materials science. Materials in medicine.

[133]  Boris N. Chichkov,et al.  Photonic and Biomedical Applications of the Two-Photon Polymerization Technique , 2011 .

[134]  Chikara Ohtsuki,et al.  Biological evaluation of an apatite-mullite glass-ceramic produced via selective laser sintering. , 2007, Acta biomaterialia.

[135]  Neil Morgan,et al.  Medical shape memory alloy applications—the market and its products , 2004 .

[136]  A. Vaccaro,et al.  The use of bioabsorbable implants in the spine. , 2003, The spine journal : official journal of the North American Spine Society.

[137]  Kenneth W. Dalgarno,et al.  Indirect selective laser sintering of apatite-wollostonite , 2008 .

[138]  H. Ohgushi,et al.  BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. , 1998, Journal of biomedical materials research.

[139]  Paulo Jorge Da Silva bartolo,et al.  Photo-curing modelling: direct irradiation , 2007 .

[140]  P. Bártolo,et al.  Additive manufacturing of tissues and organs , 2012 .

[141]  L. Yahia,et al.  Medical applications of shape memory polymers , 2007, Biomedical materials.

[142]  Bhupender S. Gupta,et al.  Co‐axial Electrospinning for Nanofiber Structures: Preparation and Applications , 2008 .

[143]  Min Wang,et al.  Developing bioactive composite materials for tissue replacement. , 2003, Biomaterials.

[144]  Sergey V. Dorozhkin,et al.  Bioceramics of calcium orthophosphates. , 2010, Biomaterials.

[145]  Sakae Saito,et al.  A new fabrication process of TiNi shape memory wire , 1993 .

[146]  F. Klocke,et al.  Consolidation phenomena in laser and powder-bed based layered manufacturing , 2007 .

[147]  M. Baumann,et al.  Hydroxyapatite accelerates differentiation and suppresses growth of MC3T3-E1 osteoblasts. , 2003, Journal of biomedical materials research. Part A.

[148]  Jan Feijen,et al.  Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[149]  Ming-Chuan Leu,et al.  EFFECT OF PARTICLE SIZE, BINDER CONTENT AND HEAT TREATMENT ON MECHANICAL PROPERTIES OF 13-93 BIOACTIVE GLASS SCAFFOLDS , 2011 .

[150]  L G Machado,et al.  Medical applications of shape memory alloys. , 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[151]  G Pradal,et al.  Cellular mechanisms of calcium phosphate ceramic degradation. , 1999, Histology and histopathology.

[152]  Dong-Yol Yang,et al.  Contour offset algorithm for precise patterning in two-photon polymerization , 2005 .

[153]  Xiaofeng Chen,et al.  Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering. , 2011, Biomaterials.

[154]  Silvia Licoccia,et al.  Fabrication of bioactive glass-ceramic foams mimicking human bone portions for regenerative medicine. , 2008, Acta biomaterialia.

[155]  J. Cesarano,et al.  Direct Ink Writing of Three‐Dimensional Ceramic Structures , 2006 .

[156]  Thomas W. Gilbert,et al.  A quantitative method for evaluating the degradation of biologic scaffold materials , 2007 .

[157]  Radovan Kovacevic,et al.  Evaluation of titanium alloy fabricated using electron beam melting system for dental applications , 2011 .

[158]  Paulo Jorge Da Silva bartolo,et al.  Metal filled resin for stereolithography metal part , 2008 .

[159]  Amit Bandyopadhyay,et al.  Application of Laser Engineered Net Shaping (LENS) to manufacture porous and functionally graded structures for load bearing implants , 2009, Journal of materials science. Materials in medicine.

[160]  Ming-Chuan Leu,et al.  Porous and strong bioactive glass (13–93) scaffolds fabricated by freeze extrusion technique , 2011 .

[161]  B Vamsi Krishna,et al.  Fabrication of porous NiTi shape memory alloy structures using laser engineered net shaping. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[162]  K. K. Wang,et al.  Geometric Modeling for Swept Volume of Moving Solids , 1986, IEEE Computer Graphics and Applications.

[163]  Geoffrey R. Mitchell,et al.  The potential of electrospinning in rapid manufacturing processes , 2011 .

[164]  Hideki Kyogoku,et al.  Laser Melting of Ti-Ni Shape Memory Alloy 668 , 2003 .

[165]  G. W. Hastings,et al.  Book reviewDefinitions in Biomaterials: Progress in Biomedical Engineering 4, Editor: D.F. Williams. Elsevier, Amsterdam, 1987, pp viii + 72, US $63.50 , 1989 .

[166]  W. Huang.  On the selection of shape memory alloys for actuators , 2002 .

[167]  J. Kruth,et al.  Micro-CT-based improvement of geometrical and mechanical controllability of selective laser melted Ti6Al4V porous structures , 2011 .

[168]  C. M. Agrawal,et al.  Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering. , 2000, Biomaterials.

[169]  Liang Hao,et al.  Selective laser melting of a stainless steel and hydroxyapatite composite for load-bearing implant development , 2009 .

[170]  Igor Shishkovsky,et al.  Porous titanium and nitinol implants synthesized by SHS/SLS: Microstructural and histomorphological analyses of tissue reactions , 2010 .

[171]  Horst Fischer,et al.  In vivo fracture resistance of implant-supported all-ceramic restorations. , 2003, The Journal of prosthetic dentistry.

[172]  Federica Chiellini,et al.  Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications , 2009, International journal of biomaterials.

[173]  K. S. Siow,et al.  Plasma Methods for the Generation of Chemically Reactive Surfaces for Biomolecule Immobilization and Cell Colonization ‐ A Review , 2006 .

[174]  T. Xie.  Recent advances in polymer shape memory , 2011 .

[175]  P. Marquis,et al.  Selective laser sintering of ultra high molecular weight polyethylene for clinical applications. , 2000, Journal of biomedical materials research.

[176]  David J. Wood,et al.  Processing and Characterization of Apatite-Wollastonite Porous Scaffolds for Bone Tissue Engineering , 2007 .

[177]  W. Yeong,et al.  Engineering functionally graded tissue engineering scaffolds. , 2008, Journal of the mechanical behavior of biomedical materials.

[178]  P. Bertrand,et al.  Manufacture of Co-Cr dental crowns and bridges by selective laser Melting technology , 2011 .

[179]  A. Lendlein,et al.  Evaluation of a degradable shape-memory polymer network as matrix for controlled drug release. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[180]  Aldo R Boccaccini,et al.  Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. , 2010, Tissue engineering. Part B, Reviews.

[181]  E. Lenz,et al.  Computer simulation of stereolithographic curing reactions: phenomenological versus mechanistic approaches , 2006 .

[182]  P. M. Gronet,et al.  Preformed acrylic cranial implants using fused deposition modeling: a clinical report. , 2003, The Journal of prosthetic dentistry.

[183]  Richard van Noort,et al.  The future of dental devices is digital. , 2012 .

[184]  Fritz Klocke,et al.  Coalescence Behaviour of Two Metallic Particles as Base Mechanism of Selective Laser Sintering , 2003 .

[185]  Bradley R Ringeisen,et al.  Jet‐based methods to print living cells , 2006, Biotechnology journal.

[186]  Chee Kai Chua,et al.  Biomanufacturing for tissue engineering: Present and future trends , 2009 .

[187]  Pierre Hardouin,et al.  Quantitative kinetic analysis of gene expression during human osteoblastic adhesion on orthopaedic materials. , 2006, Biomaterials.

[188]  C. V. van Blitterswijk,et al.  Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique. , 2004, Biomaterials.

[189]  S Wenisch,et al.  In vivo mechanisms of hydroxyapatite ceramic degradation by osteoclasts: fine structural microscopy. , 2003, Journal of biomedical materials research. Part A.

[190]  S. Agarwal,et al.  Use of electrospinning technique for biomedical applications , 2008 .

[191]  M. Gu,et al.  Two-photon polymerisation for three-dimensional micro-fabrication , 2006 .

[192]  D. Cho,et al.  Bone regeneration using a microstereolithography-produced customized poly(propylene fumarate)/diethyl fumarate photopolymer 3D scaffold incorporating BMP-2 loaded PLGA microspheres. , 2011, Biomaterials.

[193]  B D Boyan,et al.  Role of material surfaces in regulating bone and cartilage cell response. , 1996, Biomaterials.

[194]  Ryan Wicker,et al.  Stereolithography of spatially controlled multi-material bioactive poly(ethylene glycol) scaffolds. , 2010, Acta biomaterialia.

[195]  Radovan Kovacevic,et al.  The design and production of Ti-6Al-4V ELI customized dental implants , 2008 .

[196]  Yongnian Yan,et al.  Organism manufacturing engineering based on rapid prototyping principles , 2005 .

[197]  Regina Mericske-Stern,et al.  [Rehabilitation of an abraded occlusion with Procera-ZrO2 all-ceramic crowns. A case report]. , 2006, Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia.

[198]  Ryan B. Wicker,et al.  Practical Use of Hydrogels in Stereolithography for Tissue Engineering Applications , 2011 .

[199]  Kim Ragaert,et al.  Production & evaluation of PCL scaffolds for tissue engineered heart valves , 2011 .

[200]  K Asaoka,et al.  Early bone formation around calcium-ion-implanted titanium inserted into rat tibia. , 1997, Journal of biomedical materials research.

[201]  Benjamin Grosser,et al.  Customization of Load‐Bearing Hydroxyapatite Lattice Scaffolds , 2005 .

[202]  P. Tengvall,et al.  In vivo/ex vivo cellular interactions with titanium and copper , 2001, Journal of materials science. Materials in medicine.