An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India.

An outbreak of encephalitis with a case fatality rate of 78.3% was investigated among children in Gujarat State, India. Twenty-six cases were reported. Three patients had IgM antibodies to Chandipura virus. Virus was isolated from one patient with rhabdomyosarcoma in porcine stable cell lines and in suckling mice. Chandipura virus RNA was present in 9 of 20 acute-phase serum samples, and virus sequences from the present outbreak were closely related to prototype strain (1965) and Andhra Pradesh, India (2003) isolates. Serologic and molecular assays documented the absence of Japanese encephalitis virus, West Nile virus, dengue virus, and paramyxoviruses in clinical samples. The etiologic agent was Chandipura virus, which has become an important encephalitis-causing virus in India.

[1]  V. Arankalle,et al.  Detection of Chandipura Virus from Sand Flies in the Genus Sergentomyia (Diptera: Phlebotomidae) at Karimnagar District, Andhra Pradesh, India , 2005, Journal of medical entomology.

[2]  V. Arankalle,et al.  A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus , 2004, The Lancet.

[3]  T. John.  Outbreak of killer brain disease in children: mystery or missed diagnosis? , 2003, Indian pediatrics.

[4]  J. Thakare,et al.  Prevalence of West Nile virus infection in India. , 2002, The Southeast Asian journal of tropical medicine and public health.

[5]  J. Thakare,et al.  Acute encephalitis without rash in Warangal, Andhra Pradesh and Vadodara, Gujarat associated with measles virus. , 2002, The Journal of the Association of Physicians of India.

[6]  Sudhir Kumar,et al.  MEGA2: molecular evolutionary genetics analysis software , 2001, Bioinform..

[7]  J. Thakare,et al.  Japanese encephalitis in Sangli district, Maharashtra. , 1999, The Indian journal of medical research.

[8]  J. Thakare,et al.  Hemorrhagic manifestations and encephalopathy in cases of dengue in India. , 1996, The Southeast Asian journal of tropical medicine and public health.

[9]  M. Gore,et al.  Ethanethiol sensitive & resistant antibodies to enterovirus 70 in post-conjunctivitis neurological syndromes. , 1985, The Indian journal of medical research.

[10]  D. Dave,et al.  Isolation of Chandipura virus from the blood in acute encephalopathy syndrome. , 1983, The Indian journal of medical research.

[11]  M. Patankar,et al.  Etiology of the 1965 epidemic of febrile illness in Nagpur city, Maharashtra State, India. , 1972, Bulletin of the World Health Organization.

[12]  V. Dhanda,et al.  Isolation of Chandipura virus from sandflies in Aurangabad. , 1970, The Indian journal of medical research.

[13]  P. Bhatt,et al.  Chandipura: a new Arbovirus isolated in India from patients with febrile illness. , 1967, The Indian journal of medical research.

[14]  M. Chari,et al.  Jamshedpur Fever* , 1955, British medical journal.