Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.

[1]  A. Sultan,et al.  Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells , 2005, Oncogene.

[2]  J. Hahn,et al.  Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway , 2003, Experimental & Molecular Medicine.

[3]  V. Huxley,et al.  Inhibition of spontaneous breast cancer metastasis by anti-Thomsen-Friedenreich antigen monoclonal antibody JAA-F11. , 2006, Neoplasia.

[4]  Yaping Li,et al.  Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer. , 2015, Biomaterials.

[5]  M S Newman,et al.  Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes. , 1997, Biochimica et biophysica acta.

[6]  Ash A. Alizadeh,et al.  CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells , 2009, Cell.

[7]  Ronit Vogt Sionov,et al.  CD44: structure, function, and association with the malignant process. , 1997, Advances in cancer research.

[8]  Marcelle Machluf,et al.  Reconstructed stem cell nanoghosts: a natural tumor targeting platform. , 2013, Nano letters.

[9]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[10]  Chao Wang,et al.  An Imagable and Photothermal “Abraxane‐Like” Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors , 2015, Advanced materials.

[11]  Zhen Gu,et al.  Anticancer Platelet‐Mimicking Nanovehicles , 2015, Advanced materials.

[12]  F. Miller,et al.  Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. , 1992, Cancer research.

[13]  Ronnie H. Fang,et al.  Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery , 2014, Nano letters.

[14]  A. Hida,et al.  Visual assessment of Ki67 at a glance is an easy method to exclude many luminal-type breast cancers from counting 1000 cells , 2015, Breast Cancer.

[15]  S. Ralph,et al.  Inhibiting galectin-1 reduces murine lung metastasis with increased CD4+ and CD8+ T cells and reduced cancer cell adherence , 2012, Clinical & Experimental Metastasis.

[16]  Yuquan Wei,et al.  Improved tumor-targeting drug delivery and therapeutic efficacy by cationic liposome modified with truncated bFGF peptide. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[17]  Ronnie H. Fang,et al.  Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release. , 2013, Nanomedicine.

[18]  V. Torchilin.  Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[19]  Omid C. Farokhzad,et al.  Nanoparticle-Aptamer Bioconjugates , 2004, Cancer Research.

[20]  Ronnie H. Fang,et al.  Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes , 2013, Advanced materials.

[21]  R. Weinberg,et al.  A Perspective on Cancer Cell Metastasis , 2011, Science.

[22]  K. Mertz,et al.  Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis , 2014, Nature.

[23]  Daniel A. Heller,et al.  Treating metastatic cancer with nanotechnology , 2011, Nature Reviews Cancer.

[24]  K. Pienta,et al.  Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. , 2003, Cancer research.

[25]  Y. Bae,et al.  Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[26]  M. Grzelczak,et al.  Glycans as biofunctional ligands for gold nanorods: stability and targeting in protein-rich media. , 2015, Journal of the American Chemical Society.

[27]  Yin Zhang,et al.  Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence , 2013, Angiogenesis.

[28]  Ronnie H. Fang,et al.  Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles. , 2013, Nanoscale.

[29]  Mark E. Davis,et al.  Nanoparticle therapeutics: an emerging treatment modality for cancer , 2008, Nature Reviews Drug Discovery.

[30]  W. Liu,et al.  Cancer Cell Membrane‐Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging , 2016, Advanced materials.

[31]  J. Rhodes,et al.  Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis , 2010, Molecular Cancer.

[32]  S. Van Vlierberghe,et al.  SPECT/CT Imaging of Pluronic Nanocarriers with Varying Poly(ethylene oxide) Block Length and Aggregation State. , 2016, Molecular pharmaceutics.

[33]  Siling Wang,et al.  Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. , 2013, Biomaterials.

[34]  S. Barsky,et al.  The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism , 2013, Oncotarget.

[35]  Xin-guo Jiang,et al.  TRAIL and doxorubicin combination enhances anti-glioblastoma effect based on passive tumor targeting of liposomes. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[36]  Ronnie H. Fang,et al.  Nanoparticle biointerfacing via platelet membrane cloaking , 2015, Nature.

[37]  Anne L. van de Ven,et al.  Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. , 2013, Nature nanotechnology.

[38]  Richard L Wahl,et al.  131I-tositumomab therapy as initial treatment for follicular lymphoma. , 2005, The New England journal of medicine.