Molecular evolution: concepts and the origin of disciplines.

This paper focuses on the consolidation of Molecular Evolution, a field originating in the 1960s at the interface of molecular biology, biochemistry, evolutionary biology, biophysics and studies on the origin of life and exobiology. The claim is made that Molecular Evolution became a discipline by integrating different sorts of scientific traditions: experimental, theoretical and comparative. The author critically incorporates Timothy Lenoir's treatment of disciplines (1997), as well as ideas developed by Stephen Toulmin (1962) on the same subject. On their account disciplines are spaces where the social and epistemic dimensions of science are deeply and complexly interwoven. However, a more detailed account of discipline formation and the dynamics of an emerging disciplinary field is lacking in their analysis. The present essay suggests focusing on the role of scientific concepts in the double configuration of disciplines: the social/political and the epistemic order. In the case of Molecular Evolution the concepts of molecular clock and informational molecules played a central role, both in differentiating molecular from classical evolutionists, and in promoting communication between the different sorts of traditions integrated in Molecular Evolution. The paper finishes with a reflection on the historicity of disciplines, and the historicity of our concepts of disciplines.

[1]  W. Bechtel Integrating Scientific Disciplines , 1986 .

[2]  L. Pauling,et al.  A COMPARISON OF ANIMAL HEMOGLOBINS BY TRYPTIC PEPTIDE PATTERN ANALYSIS. , 1960, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Harmke Kamminga,et al.  Molecularizing Biology and Medicine: New Practices and Alliances 1910s - 1970s , 1998 .

[4]  C. Anfinsen The Molecular Basis of Evolution , 1959, The Yale Journal of Biology and Medicine.

[5]  L. Nyhart Biology Takes Form: Animal Morphology and the German Universities, 1800-1900 , 1995 .

[6]  Ernest Nagel,et al.  The Structure of Science , 1962 .

[7]  G. Graham-Smith,et al.  Blood Immunity and Blood Relationship , 1906, Bristol medico-chirurgical journal (1883).

[8]  Biology and man , 1969 .

[9]  R. Britten,et al.  Regulation of gene expression: possible role of repetitive sequences. , 1979, Science.

[10]  G. Simpson Organisms and Molecules in Evolution Studies of evolution at the molecular level lead to greater understanding and a balancing of viewpoints , 1964 .

[11]  Rates of albumin evolution in primates. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Foucault,et al.  Power/Knowledge: Selected Interviews and Other Writings 1972-1977 , 1980 .

[13]  W. Fitch,et al.  Construction of phylogenetic trees. , 1967, Science.

[14]  J. D. Aronson 'Molecules and monkeys': George Gaylord Simpson and the challenge of molecular evolution. , 2002, History and philosophy of the life sciences.

[15]  Ian Hacking,et al.  ‘Style’ for historians and philosophers☆ , 1992 .

[16]  Pierre Bourdieu,et al.  Outline of a Theory of Practice , 2020, On Violence.

[17]  T. Jukes,et al.  Molecules and evolution , 1966 .

[18]  David Sylvan,et al.  Knowledges : Historical and Critical Studies in Disciplinarity , 1993 .

[19]  L. Pauling,et al.  Evolutionary Divergence and Convergence in Proteins , 1965 .

[20]  R. Kohler, From Medical Chemistry to Biochemistry: The Making of a Biomedical Discipline , 2008 .

[21]  M. Kimura,et al.  The neutral theory of molecular evolution. , 1983, Scientific American.

[22]  E. Díaz The Rhetoric of Informational Molecules: Authority and Promises in the Early Study of Molecular Evolution , 2007, Science in Context.

[23]  E. Suárez Satellite-DNA: A case-study for the evolution of experimental techniques , 2001 .

[24]  J. Powell Molecular techniques in population genetics: a brief history. , 1994, EXS.

[25]  Karin D. Knorr-Cetina,et al.  Scientific Communities or Transepistemic Arenas of Research? A Critique of Quasi-Economic Models of Science , 1982 .

[26]  L. Pauling,et al.  Molecules as documents of evolutionary history. , 1965, Journal of theoretical biology.

[27]  P Kitcher,et al.  1953 and all that: a tale of two sciences. , 1984, The Philosophical review.

[28]  R. Richmond Non-Darwinian Evolution: A Critique , 1970, Nature.

[29]  F. Ayala,et al.  On the virtues and pitfalls of the molecular evolutionary clock. , 1986, The Journal of heredity.

[30]  Wen-Hsiung Li,et al.  Fundamentals of molecular evolution , 1990 .

[31]  R. Britten,et al.  Repeated Sequences in DNA , 1968 .

[32]  Jan Sapp,et al.  Microbial Phylogeny and Evolution: concepts and controversies. , 2004 .

[33]  M. Foucault The archaeology of knowledge , 1970 .

[34]  Lily E. Kay,et al.  The molecular vision of life , 1992 .

[35]  R. Lewontin,et al.  A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura. , 1966, Genetics.

[36]  Víctor H. Anaya-Muñoz,et al.  History, objectivity, and the construction of molecular phylogenies. , 2008, Studies in history and philosophy of biological and biomedical sciences.

[37]  E. Suárez The experimental roots of the Neutral Theory of Molecular Evolution , 1996 .

[38]  R. H. Richardson,et al.  An analysis of polymorphisms among isozyme loci in dark and light Drosophila ananassae strains from American and Western Samoa. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[39]  G J Morgan,et al.  Emile Zuckerkandl, Linus Pauling, and the Molecular Evolutionary Clock, 1959–1965 , 1998, Journal of the history of biology.

[40]  A. Blank Composite Substance, Common Notions, and Kenelm Digby's Theory of Animal Generation , 2007, Science in Context.

[41]  R. Lewontin,et al.  A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. , 1966, Genetics.

[42]  M. Kimura Evolutionary Rate at the Molecular Level , 1968, Nature.

[43]  T. Ohta,et al.  On the rate of molecular evolution , 2005, Journal of Molecular Evolution.

[44]  J. L. King,et al.  Non-Darwinian evolution. , 1969, Science.

[45]  C. Woese,et al.  Phylogenetic structure of the prokaryotic domain: The primary kingdoms , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. E. Reardon Race to the Finish: Identity and Governance in an Age of Genomics , 2004 .

[47]  Maureen A. O’Malley,et al.  Paradigm change in evolutionary microbiology. , 2005, Studies in history and philosophy of biological and biomedical sciences.

[48]  E. Margoliash PRIMARY STRUCTURE AND EVOLUTION OF CYTOCHROME C. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Mario Biagioli,et al.  Galileo, Courtier: The Practice of Science in the Culture of Absolutism , 1994 .

[50]  Joel B. Hagen,et al.  1The introduction of computers into systematic research in the United States during the 1960s , 2001 .

[51]  D. Kelley History and the disciplines : the reclassification of knowledge in early modern Europe , 1997 .

[52]  V. Bryson,et al.  Evolving Genes and Proteins. , 1965, Science.

[53]  R. Burian,et al.  Technique, task definition, and the transition from genetics to molecular genetics: Aspects of the work on protein synthesis in the laboratories of J. Monod and P. Zamecnik , 1993, Journal of the history of biology.

[54]  R. Lewontin,et al.  The Genetic Basis of Evolutionary Change , 2022 .

[55]  Wim J. van der Steen,et al.  Towards disciplinary disintegration in biology , 1993 .

[56]  William Bechtel,et al.  Integrating sciences by creating new disciplines: The case of cell biology , 1993 .

[57]  M. Dietrich,et al.  Paradox and Persuasion: Negotiating the Place of Molecular Evolution within Evolutionary Biology , 1998, Journal of the history of biology.

[58]  B. Schierwater,et al.  Molecular Ecology and Evolution: Approaches and Applications , 1995, Experientia Supplementum.

[59]  E. Davidson,et al.  The hardwiring of development: organization and function of genomic regulatory systems. , 1997, Development.

[60]  M. Dietrich,et al.  The origins of the neutral theory of molecular evolution , 1994, Journal of the history of biology.

[61]  S. Washburn Classification and human evolution , 1963 .

[62]  R. Kohler,,et al.  The Enzyme Theory and the Origin of Biochemistry , 1973, Isis.

[63]  H. Harris C. Genetics of Man Enzyme polymorphisms in man , 1966, Proceedings of the Royal Society of London. Series B. Biological Sciences.