DECREASED BLOOD PRESSURE IN RESPONSE TO AN ANGIOTENSIN II ANTAGONIST IN ADDISON'S DISEASE

The synthetic angiotensin II antagonist, 1‐sarcosine, 8‐isoleucine angiotensin II was infused in two patients with untreated Addison's disease. Blood pressure decreased following infusion of this angiotensin II antagonist. Re‐infusion of the antagonist after cortisol replacement therapy for one month caused a slight increase in blood pressure. Addison's disease is one of the conditions in which the renin‐angiotensin system is involved in the maintenance of blood pressure.

[1]  H. Mikami,et al.  Sodium depletion and blood pressure response to 1‐sarcosine, 8‐isoleucine angiotensin II in hypertension , 1978, Clinical pharmacology and therapeutics.

[2]  T. Ogihara,et al.  A non-chromatographic non-extraction radioimmunoassay for serum aldosterone. , 1977, The Journal of clinical endocrinology and metabolism.

[3]  R. Noth,et al.  Effects of angiotensin II blockade by saralasin in normal man. , 1977, The Journal of clinical endocrinology and metabolism.

[4]  T. Ogihara,et al.  Effects of two angiotensin II analogous on blood pressure in normal subjects with various sodium balances. , 1977, Life sciences.

[5]  E. Haber.  George C. Griffith lecture. The role of renin in normal and pathological cardiovascular homeostasis. , 1976, Circulation.

[6]  S. Shimbo,et al.  Blood pressure fall by angiotensin II antagonist in patients with Bartter's syndrome. , 1976, The Journal of clinical endocrinology and metabolism.

[7]  K. Miyai,et al.  [Serum cortisol radioimmunoassay using 125I-cortisol, and polyethylene glycol]. , 1976, Kaku igaku. The Japanese journal of nuclear medicine.

[8]  D. Streeten,et al.  Effect of blockade of angiotensin II on blood pressure, renin and aldosterone in cirrhosis. , 1976, Kidney international.

[9]  J. Laragh,et al.  Specific inhibition of the renin-angiotensin system: A key to understanding blood pressure regulation. , 1974, Progress in cardiovascular diseases.

[10]  A. Samuels,et al.  The regulation of pressure by the renin angiotensin system , 1973 .

[11]  T. Ogihara,et al.  [Measurement of plasma renin activity by angiotension I radioimmunoassay]. , 1973, Kaku igaku. The Japanese journal of nuclear medicine.

[12]  J. Laragh,et al.  Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats , 1973, Science.

[13]  J. Brown,et al.  VARIATIONS IN PLASMA RENIN CONCENTRATION IN SEVERAL PHYSIOLOGICAL AND PATHOLOGICAL STATES. , 1964, Canadian Medical Association journal.

[14]  J. Sheath.  Factors in the colorimetric estimation of 17-ketosteroids in urine. , 1959, The Australian journal of experimental biology and medical science.

[15]  C. C. Porter,et al.  A quantitative color reaction for cortisone and related 17,21-dihydroxy-20-ketosteroids. , 1950, The Journal of biological chemistry.