Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

[1]  Tsung-Cheng Chang,et al.  Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours , 2017, Nature Communications.

[2]  Eckart Meese,et al.  Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. , 2015, Cancer cell.

[3]  P. Grundy,et al.  Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour , 2014, Nature Communications.

[4]  Hao Zhu,et al.  Lin28 sustains early renal progenitors and induces Wilms tumor , 2014, Genes & development.

[5]  Gretchen M. Williams,et al.  DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma , 2014, Modern Pathology.

[6]  M. Peter,et al.  MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells , 2014, Oncogene.

[7]  A. Nicholson.  Ribonuclease III mechanisms of double-stranded RNA cleavage , 2013, Wiley interdisciplinary reviews. RNA.

[8]  J. Lupski,et al.  Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy , 2013, Genome Medicine.

[9]  James R. Anderson,et al.  Children's Oncology Group's 2013 blueprint for research: Renal tumors , 2013, Pediatric blood & cancer.

[10]  W. Foulkes,et al.  Biallelic DICER1 mutations occur in Wilms tumours , 2013, The Journal of pathology.

[11]  A. Chinnaiyan,et al.  miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers , 2013, BMC Genomics.

[12]  Gerald Hoefler,et al.  The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration. , 2013, Human pathology.

[13]  Jie Chen,et al.  Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation , 2013, Proceedings of the National Academy of Sciences.

[14]  R. Müller,et al.  Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT) , 2013, Journal of Molecular Medicine.

[15]  J. Lupski,et al.  De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome , 2013, Genome Medicine.

[16]  J. Kreidberg,et al.  MicroRNAs in renal development , 2013, Pediatric Nephrology.

[17]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[18]  J. Miller,et al.  Predicting the Functional Effect of Amino Acid Substitutions and Indels , 2012, PloS one.

[19]  Chiang-Ching Huang,et al.  Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study. , 2012, Neoplasia.

[20]  Arjun Bhutkar,et al.  In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. , 2012, RNA.

[21]  Pablo Cingolani,et al.  © 2012 Landes Bioscience. Do not distribute. , 2022 .

[22]  Pablo Cingolani,et al.  Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift , 2012, Front. Gene..

[23]  Jessica C. Ebert,et al.  Computational Techniques for Human Genome Resequencing Using Mated Gapped Reads , 2012, J. Comput. Biol..

[24]  Kenneth H. Buetow,et al.  Bioinformatics Applications Note Sequence Analysis Bambino: a Variant Detector and Alignment Viewer for Next-generation Sequencing Data in the Sam/bam Format , 2022 .

[25]  A. Nicholson,et al.  DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome , 2011, Journal of Medical Genetics.

[26]  Fei Gao,et al.  Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation. , 2011, The Journal of clinical investigation.

[27]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[28]  H. Allgayer,et al.  Loss of miR-200c Expression Induces an Aggressive, Invasive, and Chemoresistant Phenotype in Non–Small Cell Lung Cancer , 2010, Molecular Cancer Research.

[29]  Daniel Rios,et al.  Bioinformatics Applications Note Databases and Ontologies Deriving the Consequences of Genomic Variants with the Ensembl Api and Snp Effect Predictor , 2022 .

[30]  J. Vandesompele,et al.  Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo , 2010, Cell Death and Differentiation.

[31]  P. Bork,et al.  A method and server for predicting damaging missense mutations , 2010, Nature Methods.

[32]  Robert B. Hartlage,et al.  This PDF file includes: Materials and Methods , 2009 .

[33]  Satoshi Shibata,et al.  A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery , 2009, Science.

[34]  Gretchen M. Williams,et al.  DICER1 Mutations in Familial Pleuropulmonary Blastoma , 2009, Science.

[35]  C. Croce,et al.  MicroRNAs in Cancer. , 2009, Annual review of medicine.

[36]  H. Ford,et al.  Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations* , 2009, The Journal of Biological Chemistry.

[37]  Richard Durbin,et al.  Sequence analysis Fast and accurate short read alignment with Burrows – Wheeler transform , 2009 .

[38]  R. Gregory,et al.  Many roads to maturity: microRNA biogenesis pathways and their regulation , 2009, Nature Cell Biology.

[39]  Cheng Cheng,et al.  Reference alignment of SNP microarray signals for copy number analysis of tumors , 2009, Bioinform..

[40]  M. Sternberg,et al.  Protein structure prediction on the Web: a case study using the Phyre server , 2009, Nature Protocols.

[41]  A. McMahon,et al.  Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. , 2008, Cell stem cell.

[42]  Ryan D. Morin,et al.  Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing. , 2008, BioTechniques.

[43]  V. Huff,et al.  Wilms tumor genetics: Mutations in WT1, WTX, and CTNNB1 account for only about one‐third of tumors , 2008, Genes, chromosomes & cancer.

[44]  Sun-Mi Park,et al.  The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.

[45]  H. Ford,et al.  The six family of homeobox genes in development and cancer. , 2008, Advances in cancer research.

[46]  T. Golub,et al.  Impaired microRNA processing enhances cellular transformation and tumorigenesis , 2007, Nature Genetics.

[47]  G. Dressler,et al.  Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney , 2006, The EMBO journal.

[48]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M. Rivera,et al.  Wilms' tumour: connecting tumorigenesis and organ development in the kidney , 2005, Nature Reviews Cancer.

[50]  Pablo Tamayo,et al.  Metagenes and molecular pattern discovery using matrix factorization , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C. Glass,et al.  Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis , 2003, Nature.

[52]  C. Laclef,et al.  Six1 is required for the early organogenesis of mammalian kidney , 2003, Development.

[53]  J. Dome,et al.  Improved Survival for Patients With Recurrent Wilms Tumor: The Experience at St. Jude Children's Research Hospital , 2002, Journal of pediatric hematology/oncology.

[54]  A. Feinberg,et al.  Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. , 2001, Journal of the National Cancer Institute.

[55]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Elizabeth M. Smigielski,et al.  dbSNP: the NCBI database of genetic variation , 2001, Nucleic Acids Res..

[57]  C. Amos,et al.  Frequent Association of β-Catenin and WT1 Mutations in Wilms Tumors , 2000 .

[58]  N. Nowak,et al.  Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations , 1994, Nature Genetics.

[59]  L. Strong,et al.  Genetic mosaicism in normal tissues of Wilms' tumour patients , 1993, Nature Genetics.

[60]  N. Kiviat,et al.  Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor. , 1990, Pediatric pathology.

[61]  E. Beckwith,et al.  Histopathology and prognosis of Wilms tumor Results from the first national wilms' tumor study , 1978, Cancer.