Carbon nanotube-modified monolithic polymethacrylate pipette tips for (micro)solid-phase extraction of antidepressants from urine samples

AbstractThis work evaluates the potential of methacrylate monoliths with multi-walled carbon nanotubes incorporated into the polymeric network for the extraction of antidepressants from human urine. The method is based on a micropipette solid-phase extraction tip containing a hybrid monolithic material covalently attached to the polypropylene housing. A polymer layer made from poly(ethylene dimethacrylate) was bound to the inner surface of a polypropylene tip via UV grafting. The preparation of the monolith and the microextraction steps were optimized in terms of adsorption capacity. Limits of detection ranged from 9 to 15 μg·L−1. The average precision of the method varied between 3 and 5% (intra-tips), and from 4 to 14% (inter-tips). The accuracy of the method was evaluated through a recovery study by using spiked samples. Graphical abstractHybrid polymer monoliths containing multi-walled carbon nanotubes (MWCNTs) were prepared in pipette tips by photo-polymerization approach. The extraction devices were used for the extraction of antidepressants in urine samples.

[1]  Miguel Valcárcel,et al.  Micro-solid phase extraction based on oxidized single-walled carbon nanohorns immobilized on a stir borosilicate disk: Application to the preconcentration of the endocrine disruptor benzophenone-3 , 2014 .

[2]  Robert H. Davis,et al.  A Novel Sequential Photoinduced Living Graft Polymerization , 2000 .

[3]  K. Pyrzyńska.  Carbon nanotubes as sorbents in the analysis of pesticides. , 2011, Chemosphere.

[4]  R. Ito,et al.  Improvement and validation the method using dispersive liquid-liquid microextraction with in situ derivatization followed by gas chromatography-mass spectrometry for determination of tricyclic antidepressants in human urine samples. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[5]  News from ABC: Editorial board and features , 2012, Analytical and Bioanalytical Chemistry.

[6]  Salasiah Endud,et al.  Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography-mass spectrometry for the determination of antidepressant drugs in biological fluids. , 2017, Journal of separation science.

[7]  M. Jafari,et al.  A platinum wire coated with a composite consisting of poly pyrrole and poly(ɛ-caprolactone) for solid phase microextraction of the antidepressant imipramine prior to its determination via ion mobility spectrometry , 2016, Microchimica Acta.

[8]  Ali Asghar Rajabi,et al.  Solid-phase microextraction based on cetyltrimethylammonium bromide-coated magnetic nanoparticles for determination of antidepressants from biological fluids , 2012, Medicinal Chemistry Research.

[9]  Shahram Seidi,et al.  In-tube electrochemically controlled solid phase microextraction of amitriptyline, imipramine and chlorpromazine from human plasma by using an indole-thiophene copolymer nanocomposite , 2017, Microchimica Acta.

[10]  S. Cárdenas,et al.  Preparation of porous methacrylate monoliths with oxidized single-walled carbon nanohorns for the extraction of nonsteroidal anti-inflammatory drugs from urine samples , 2017, Microchimica Acta.

[11]  H. Çabuk,et al.  Optimization of magnetic extraction by experimental design methodology for the determination of antidepressants in biological samples , 2015 .

[12]  Miguel Valcárcel,et al.  Present and future applications of carbon nanotubes to analytical science , 2005, Analytical and bioanalytical chemistry.

[13]  E. Hilder,et al.  Fabrication of porous polymer monoliths covalently attached to the walls of channels in plastic microdevices , 2003, Electrophoresis.

[14]  Y. Yamini,et al.  Three-phase hollow fiber microextraction based on two immiscible organic solvents for determination of tricyclic antidepressant drugs: comparison with conventional three-phase hollow fiber microextraction. , 2012, Journal of chromatography. A.

[15]  Bryan G. Reuben,et al.  Pharmaceutical Chemicals in Perspective , 1989 .

[16]  V. Samanidou,et al.  Development and validation of an HPLC method for the determination of benzodiazepines and tricyclic antidepressants in biological fluids after sequential SPE. , 2008, Journal of separation science.

[17]  E. Simó-Alfonso,et al.  Optimised procedures for the reversed-phase liquid chromatographic analysis of formulations containing tricyclic antidepressants. , 2003, Journal of pharmaceutical and biomedical analysis.

[18]  Juan Manuel Jiménez-Soto,et al.  Solid Phase (Micro)extraction Tools Based on Carbon Nanotubes and Related Nanostructures , 2010 .

[19]  M. Valcárcel,et al.  Improved microextraction of selected triazines using polymer monoliths modified with carboxylated multi-walled carbon nanotubes , 2015, Microchimica Acta.

[20]  K. Jinno,et al.  Direct coupling of microcolumn liquid chromatography with in-tube solid-phase microextraction for the analysis of antidepressant drugs. , 2000, In Analysis.

[21]  H. Bagheri,et al.  Microextraction of antidepressant drugs into syringes packed with a nanocomposite consisting of polydopamine, silver nanoparticles and polypyrrole , 2015, Microchimica Acta.

[22]  F. Foret,et al.  Nanoparticle-modified monolithic pipette tips for phosphopeptide enrichment , 2013, Analytical and Bioanalytical Chemistry.

[23]  Juan Manuel Jiménez-Soto,et al.  Evaluation of carbon nanocones/disks as sorbent material for solid-phase extraction. , 2009, Journal of chromatography. A.

[24]  Siyavash Kazemi Movahed,et al.  Application of a new fiber coating based on electrochemically reduced graphene oxide for the cold-fiber headspace solid-phase microextraction of tricyclic antidepressants. , 2014, Journal of separation science.

[25]  B. Paull,et al.  Pipette-tip selective extraction of glycoproteins with lectin modified gold nano-particles on a polymer monolithic phase. , 2011, The Analyst.

[26]  Wei Chen,et al.  Adsorption of polar and nonpolar organic chemicals to carbon nanotubes. , 2007, Environmental science & technology.

[27]  M. Valcárcel,et al.  UV-polymerized butyl methacrylate monoliths with embedded carboxylic single-walled carbon nanotubes for CEC applications , 2014, Analytical and Bioanalytical Chemistry.

[28]  C. Wakasugi,et al.  Forensic analysis of eleven cyclic antidepressants in human biological samples using a new reversed-phase chromatographic column of 2 microm porous microspherical silica gel. , 1997, Journal of chromatography. B, Biomedical sciences and applications.

[29]  F. Lanças,et al.  Optimization of the SPME parameters and its online coupling with HPLC for the analysis of tricyclic antidepressants in plasma samples. , 2006, Journal of chromatographic science.

[30]  M. Valcárcel,et al.  Preparation and evaluation of micro and meso porous silica monoliths with embedded carbon nanoparticles for the extraction of non-polar compounds from waters. , 2016, Journal of chromatography. A.

[31]  Z. Es’haghi,et al.  Optimization of a novel method for determination of benzene, toluene, ethylbenzene, and xylenes in hair and waste water samples by carbon nanotubes reinforced sol-gel based hollow fiber solid phase microextraction and gas chromatography using factorial experimental design. , 2011, Journal of chromatography. A.

[32]  X. Wang,et al.  Online coupling of in-tube solid-phase microextraction with direct analysis in real time mass spectrometry for rapid determination of triazine herbicides in water using carbon-nanotubes-incorporated polymer monolith. , 2014, Analytical chemistry.

[33]  A. Mack,et al.  Clinical Response and Risk for Reported Suicidal Ideation and Suicide Attempts in Pediatric Antidepressant Treatment: A Meta-analysis of Randomized Controlled Trials , 2009 .