Clock and induction model for somitogenesis

After many years of research, somitogenesis is still one of the major unresolved problems in developmental biology. Recent experimental findings show a novel type of pattern formation in which a signal sweeps along the presomitic mesoderm and narrows simultaneously as a new somite is formed. The signal then residues in the posterior half of the new somite, and another wave begins to sweep up from the caudal end. This behaviour is not easily explained by the existing theoretical models. We present a new model for somitogenesis that can account for this behaviour and is consistent with previous experimental observations. Dev Den;217:415–420. © 2000 Wiley‐Liss, Inc.

[1]  O. Pourquié,et al.  Somitogenesis: segmenting a vertebrate. , 1998, Current opinion in genetics & development.

[2]  I. Greenwald,et al.  LIN-12/Notch signaling: lessons from worms and flies. , 1998, Genes & development.

[3]  A. Polezhaev.  MATHEMATICAL MODELLING OF THE MECHANISM OF VERTEBRATE SOMITIC SEGMENTATION , 1995 .

[4]  M. Catala,et al.  Organization and development of the tail bud analyzed with the quail-chick chimaera system , 1995, Mechanisms of Development.

[5]  R. Bellairs.  THE DEVELOPMENT OF SOMITES IN THE CHICK EMBRYO. , 1963, Journal of embryology and experimental morphology.

[6]  S. Meier.  Development of the chick embryo mesoblast. Formation of the embryonic axis and establishment of the metameric pattern. , 1979, Developmental biology.

[7]  Hans Meinhardt,et al.  Models of Segmentation , 1986 .

[8]  Nigel A. Brown,et al.  Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation , 1998, Current Biology.

[9]  R. Keynes,et al.  Periodic segmental anomalies induced by heat shock in the chick embryo are associated with the cell cycle. , 1989, Development.

[10]  J. Rossant,et al.  Notch1 is required for the coordinate segmentation of somites. , 1995, Development.

[11]  K.,et al.  Control of somite number in normal and amputated mutant mouse embryos: an experimental and a theoretical analysis. , 1978, Journal of embryology and experimental morphology.

[12]  M. H. Angelis,et al.  Maintenance of somite borders in mice requires the Delta homologue Dll1 , 1997, Nature.

[13]  R. Keynes,et al.  Mechanisms of vertebrate segmentation. , 1988, Development.

[14]  R. Bellairs.  The segmentation of somites in the chick embryo , 1980 .

[15]  H. Aoyama,et al.  Determination of somite cells: independence of cell differentiation and morphogenesis. , 1988, Development.

[16]  Olivier Pourquié,et al.  The lunatic Fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos , 1998, Current Biology.

[17]  D. S. Packard,et al.  The influence of axial structures on chick somite formation. , 1976, Developmental biology.

[18]  P. Bork,et al.  Secreted Fringe-like Signaling Molecules May Be Glycosyltransferases , 1997, Cell.

[19]  T. Gridley,et al.  Defects in somite formation in lunatic fringe-deficient mice , 1998, Nature.

[20]  R. Keynes,et al.  Heat shock causes repeated segmental anomalies in the chick embryo. , 1988, Development.

[21]  H. Meinhardt.  Models of biological pattern formation , 1982 .

[22]  C. Stern,et al.  Fates and migratory routes of primitive streak cells in the chick embryo. , 1996, Development.

[23]  T. Mak,et al.  Disruption of the mouse RBP-J kappa gene results in early embryonic death. , 1995, Development.

[24]  Claudio D. Stern,et al.  Mitotic activity during somite segmentation in the early chick embryo , 2004, Anatomy and Embryology.

[25]  D. Price,et al.  Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm , 1997, Nature.

[26]  R. Keynes,et al.  A cell lineage analysis of segmentation in the chick embryo. , 1988, Development.

[27]  O. Pourquié.  Clocks regulating developmental processes , 1998, Current Opinion in Neurobiology.

[28]  A. Polezhaev.  A mathematical model of the mechanism of vertebrate somitic segmentation. , 1992, Journal of theoretical biology.

[29]  J. Campos-Ortega,et al.  Expression domains of a zebrafish homologue of the Drosophila pair-rule gene hairy correspond to primordia of alternating somites. , 1996, Development.

[30]  R. Bellairs,et al.  Heat Shock Effects in Chick Embryos , 1986 .

[31]  S. Meier,et al.  Somitomeres: The Primordial Body Segments , 1986 .

[32]  R. Bellairs,et al.  An experimental analysis of somite segmentation in the chick embryo. , 1980, Journal of embryology and experimental morphology.

[33]  K. Irvine,et al.  Fringe modulates Notch–ligand interactions , 1997, Nature.

[34]  E. Chernoff,et al.  Calcium dependence and contraction in somite formation. , 1982, Tissue & cell.

[35]  J. Cooke,et al.  A gene that resuscitates a theory--somitogenesis and a molecular oscillator. , 1998, Trends in genetics : TIG.

[36]  E. C. Zeeman,et al.  A clock and wavefront model for control of the number of repeated structures during animal morphogenesis. , 1976, Journal of theoretical biology.

[37]  O. Pourquié,et al.  Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis , 1997, Cell.

[38]  D. A. Ede,et al.  Somites in Developing Embryos , 1986, NATO ASI Series.

[39]  D. Turner,et al.  Somite pattern regulation in the avian segmental plate mesoderm. , 1993, Development.

[40]  R. Bellairs.  The Tail Bud and Cessation of Segmentation in the Chick Embryo , 1986 .

[41]  B. Birren,et al.  The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries , 1998, Nature Genetics.

[42]  J. Rossant,et al.  Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse , 1999, Current Biology.

[43]  J. M. W. Slack,et al.  From Egg to Embryo , 1983 .

[44]  J. Lewis,et al.  Notch signalling and the control of cell fate choices in vertebrates. , 1998, Seminars in cell & developmental biology.

[45]  Yvonne A. Evrard,et al.  lunatic fringe is an essential mediator of somite segmentation and patterning , 1998, Nature.

[46]  D. Weisblat,et al.  Evolution of developmental mechanisms: spatial and temporal modes of rostrocaudal patterning. , 1994, Current topics in developmental biology.

[47]  A. Evrard.  Galaxy clusters: Well of darkness , 1998, Nature.