Genetic algorithms and MCML program for recovery of optical properties of homogeneous turbid media

In this paper, we present and validate a new method for optical properties recovery of turbid media with slab geometry. This method is an iterative method that compares diffuse reflectance and transmittance, measured using integrating spheres, with those obtained using the known algorithm MCML. The search procedure is based in the evolution of a population due to selection of the best individual, i.e., using a genetic algorithm. This new method includes several corrections such as non-linear effects in integrating spheres measurements and loss of light due to the finite size of the sample. As a potential application and proof-of-principle experiment of this new method, we use this new algorithm in the recovery of optical properties of blood samples at different degrees of coagulation.

[1]  Mitsuo Gen,et al.  Genetic algorithms and engineering design , 1997 .

[2]  I. Yaroslavsky,et al.  Inverse hybrid technique for determining the optical properties of turbid media from integrating-sphere measurements. , 1996, Applied optics.

[3]  Michael S. Patterson,et al.  Quantitative Reflectance Spectrophotometry For The Noninvasive Measurement Of Photosensitizer Concentration In Tissue During Photodynamic Therapy , 1989 .

[4]  A J Welch,et al.  Accuracies of the diffusion approximation and its similarity relations for laser irradiated biological media. , 1989, Applied optics.

[5]  Gerald W. Lucassen,et al.  The effect of light losses in double integrating spheres on optical properties estimation , 1999 .

[6]  A J Welch,et al.  Tissue optical property measurements: Overestimation of absorption coefficient with spectrophotometric techniques , 1994, Lasers in surgery and medicine.

[7]  S Andersson-Engels,et al.  Measurements of the optical properties of tissue in conjunction with photodynamic therapy. , 1995, Applied optics.

[8]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[9]  Scott A Prahl,et al.  Preparation and characterization of polyurethane optical phantoms. , 2006, Journal of biomedical optics.

[10]  H. Brooks,et al.  Medical physiology , 1961 .

[11]  J. S. Dam,et al.  Multiple polynomial regression method for determination of biomedical optical properties from integrating sphere measurements. , 2000, Applied optics.

[12]  S L Jacques,et al.  Modeling optical and thermal distributions in tissue during laser irradiation , 1987, Lasers in surgery and medicine.

[13]  P. Barber.  Absorption and scattering of light by small particles , 1984 .

[14]  P. Kubelka,et al.  New Contributions to the Optics of Intensely Light-Scattering Materials. Part I , 1948 .

[15]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[16]  Wim Verkruysse,et al.  Changes in Optical Properties of Human Whole Blood in vitro Due to Slow Heating , 1997, Photochemistry and photobiology.

[17]  R. Anderson,et al.  Determination of optical properties of turbid media using pulsed photothermal radiometry , 1992, Physics in medicine and biology.

[18]  B L Diffey.  A mathematical model for ultraviolet optics in skin. , 1983, Physics in medicine and biology.

[19]  Martina Meinke,et al.  Optical properties of platelets and blood plasma and their influence on the optical behavior of whole blood in the visible to near infrared wavelength range. , 2007, Journal of biomedical optics.

[20]  Ton G van Leeuwen,et al.  Oxygen saturation-dependent absorption and scattering of blood. , 2004, Physical review letters.

[21]  A. Welch,et al.  Determining the optical properties of turbid mediaby using the adding-doubling method. , 1993, Applied optics.

[22]  S Andersson-Engels,et al.  T-matrix computations of light scattering by red blood cells. , 1998, Applied optics.

[23]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[24]  P. Kubelka,et al.  New contributions to the optics of intensely light-scattering materials. , 1954, Journal of the Optical Society of America.

[25]  S. A. Prahl,et al.  A Monte Carlo model of light propagation in tissue , 1989, Other Conferences.

[26]  A Roggan,et al.  Optical properties of ocular fundus tissues--an in vitro study using the double-integrating-sphere technique and inverse Monte Carlo simulation. , 1995, Physics in medicine and biology.

[27]  L. Richards,et al.  Multiple scattering calculations for technology. , 1971, Applied optics.

[28]  A. Roggan,et al.  Optical Properties of Circulating Human Blood in the Wavelength Range 400-2500 nm. , 1999, Journal of biomedical optics.

[29]  J. A. Delgado Atencio,et al.  Validation of a new algorithm for the recovery of optical properties from turbid samples: GA-MCML against IAD program , 2011, International Commission for Optics.

[30]  M. Kohl,et al.  Near-infrared optical properties of ex vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique. , 1998, Physics in medicine and biology.

[31]  Akira Ishimaru,et al.  Wave propagation and scattering in random media , 1997 .

[32]  Martina Meinke,et al.  Determination of optical properties of human blood in the spectral range 250 to 1100 nm using Monte Carlo simulations with hematocrit-dependent effective scattering phase functions. , 2006, Journal of biomedical optics.

[33]  V. Tuchin,et al.  Blood-flow measurements with a small number of scattering events. , 2000, Applied optics.

[34]  A. Lathrop.  Diffuse Scattered Radiation Theories of Duntley and of Kubelka–Munk , 1965 .

[35]  Henricus J. C. M. Sterenborg,et al.  Two integrating spheres with an intervening scattering sample , 1992 .

[36]  D. Boas,et al.  Determination of optical properties and blood oxygenation in tissue using continuous NIR light , 1995, Physics in medicine and biology.

[37]  D. Sardar,et al.  Optical Properties of Whole Blood , 1998, Lasers in Medical Science.

[38]  Seibert Q. Duntley,et al.  The Optical Properties of Diffusing Materials , 1942 .

[39]  J. Pickering,et al.  Double-integrating-sphere system for measuring the optical properties of tissue. , 1993, Applied optics.

[40]  Obtención de los parámetros ópticos de la piel usando algoritmos genéticos y MCML , 2011 .