In-vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer

In this present study we investigate the Radachlorin photosensitizer accumulation in K562 cells and Hela cells and determined the cell viability after PDT. Using the macroscopic singlet oxygen modeling and cellular photosensitizer concentration the singlet oxygen threshold doses for K562 cells and Hela cells were calculated.

[1]  Jarod C Finlay,et al.  In-vivo singlet oxygen threshold doses for PDT , 2015, Photonics & lasers in medicine.

[2]  Michael S Patterson,et al.  Calculation of Singlet Oxygen Dose from Photosensitizer Fluorescence and Photobleaching During mTHPC Photodynamic Therapy of MLL Cells ¶ , 2005, Photochemistry and photobiology.

[3]  A. A. Rusanov,et al.  Pulse mode of laser photodynamic treatment induced cell apoptosis. , 2016, Photodiagnosis and photodynamic therapy.

[4]  V. Ostatná,et al.  Interaction of singlet oxygen with bovine serum albumin and the role of the protein nano-compartmentalization. , 2016, Free radical biology & medicine.

[5]  Mark A. Weston,et al.  Calculation of Singlet Oxygen Dose Using Explicit and Implicit Dose Metrics During Benzoporphyrin Derivative Monoacid Ring A (BPD‐MA)‐PDT In Vitro and Correlation with MLL Cell Survival , 2011, Photochemistry and photobiology.

[6]  A. Krasnovsky,et al.  Photochemical investigation of the IR absorption bands of molecular oxygen in organic and aqueous environment , 2012, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[7]  Sabrina Oliveira,et al.  Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions , 2017, Cancers.

[8]  Jin-Chul Ahn,et al.  Chlorin e6 Derivative Radachlorin Mainly Accumulates in Mitochondria, Lysosome and Endoplasmic Reticulum and Shows High Affinity toward Tumors in Nude Mice in Photodynamic Therapy , 2014, Photochemistry and photobiology.

[9]  Ken Kang-Hsin Wang,et al.  Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals. , 2008, Medical physics.

[10]  Jarod C Finlay,et al.  Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling , 2010, Journal of biophotonics.

[11]  Thomas H Foster,et al.  Photophysical Parameters, Photosensitizer Retention and Tissue Optical Properties Completely Account for the Higher Photodynamic Efficacy of meso-Tetra-Hydroxyphenyl-Chlorin vs Photofrin¶ , 2005, Photochemistry and photobiology.