Fabrication of hollow CuO/PANI hybrid nanofibers for non-enzymatic electrochemical detection of H2O2 and glucose

Abstract Herein, the hollow CuO/polyaniline (CuO/ PANI) nano-hybrid fibers have been prepared as a novel electrochemical sensor for accurately detecting hydrogen peroxide (H2O2) and glucose. The unique hollow structure of PANI fibers can be achieved by utilizing the polyamic acid (PAA) electrospun fibers as a sacrificial template to promote accessible surface area and reactive sites for sensing. Moreover, in order to enhance the electrochemical properties of PANI fibers, CuO nanoparticles were doped onto the hollow PANI surfaces. Scanning electron microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) characterizations identify the successful fabrication of hollow CuO/PANI nano-hybrid fibers, which have been designed as a novel non-enzymatic electrochemical biosensor. Furthermore, the H2O2 and glucose sensing tests indicate that the as-prepared non-enzymatic electrochemical biosensor exhibits a wide range, low detection limit, high selectivity, and long-term stability, suggesting the potential application in food security, biomedicine, environmental detection, and pharmaceutical analysis.

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