We systematically generalize the exotic He-B phase, which not only exhibits unconventional symmetry but is also isotropic and topologically non-trivial, to arbitrary partial-wave channels with multi-component fermions. The concrete example with four-component fermions is illustrated including the isotropic f , p and d-wave pairings in the spin septet, triplet, and quintet channels, respectively. The odd partial-wave channel pairings are topologically non-trivial, while pairings in even partial-wave channels are topologically trivial. The topological index reaches the largest value of N in the p-wave channel (N is half of the fermion component number). The surface spectra exhibit multiple linear and even high order Dirac cones. Applications to multi-orbital condensed matter systems and multi-component ultra-cold large spin fermion systems are discussed.