Admission hypocalcemia in pediatric major trauma patients—An uncommon phenomenon associated with an increased need for urgent blood transfusion

Hemorrhage is a leading cause of death among children. Recent data from adult trauma suggests that early, transfusion‐unrelated, hypocalcemia is common and that it is associated with an increased need for blood transfusion, mortality, and coagulopathy. The objectives of this study are to evaluate the prevalence of admission hypocalcemia in severely injured children and its correlation with urgent blood transfusion.

[1]  S. Moulton,et al.  It is time for TEG in pediatric trauma: unveiling meaningful alterations in children who undergo massive transfusion , 2021, Pediatric Surgery International.

[2]  S. Shackelford,et al.  The diamond of death: Hypocalcemia in trauma and resuscitation. , 2020, The American journal of emergency medicine.

[3]  C. Groombridge,et al.  Hypocalcemia in trauma patients: A systematic review , 2020, The journal of trauma and acute care surgery.

[4]  A. Sauaia,et al.  Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock. , 2020, The journal of trauma and acute care surgery.

[5]  A. Givon,et al.  Comparison between traumatic brain injury with and without concomitant injuries: an analysis based on a national trauma registry 2008–2016 , 2020, Brain injury.

[6]  Sangki Oak,et al.  A review of transfusion- and trauma-induced hypocalcemia. Is it time to change the lethal triad to the lethal diamond? , 2019, The journal of trauma and acute care surgery.

[7]  K. Jung,et al.  Damage control resuscitation in children , 2019, Pediatric Emergency Medicine Journal.

[8]  J. Vincent,et al.  The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition , 2019, Critical Care.

[9]  R. Thakker,et al.  Hypercalcemic Disorders in Children , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  K. Wheeler,et al.  Validation of the age-adjusted shock index using pediatric trauma quality improvement program data. , 2017, Journal of pediatric surgery.

[11]  S. Ostrowski,et al.  Transfusion therapy in paediatric trauma patients: a review of the literature , 2015, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.

[12]  M. Livingston,et al.  Massive transfusion in paediatric and adolescent trauma patients: incidence, patient profile, and outcomes prior to a massive transfusion protocol. , 2014, Injury.

[13]  T. Fabian,et al.  Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patients. , 2011, The Journal of trauma.

[14]  M. Coulthard,et al.  Minimising changes in plasma calcium and magnesium concentrations during plasmapheresis , 2007, Pediatric Nephrology.

[15]  R. Gabbay,et al.  Do early ionized calcium levels really matter in trauma patients? , 2006, The Journal of trauma.

[16]  S. L. Barcelona,et al.  Intraoperative pediatric blood transfusion therapy: a review of common issues. Part I: hematologic and physiologic differences from adults; metabolic and infectious risks , 2005, Paediatric anaesthesia.

[17]  R. Bilkovski,et al.  Arterial and venous ionized calcium measurements: Is there a difference? , 2004 .

[18]  H. Keenan,et al.  Epidemiology and prevention of childhood injuries , 2002, Critical care medicine.

[19]  D. Hoaglin,et al.  Ionized Hypocalcemia after Fresh Frozen Plasma Administration to Thermally Injured Children: Effects of Infusion Rate, Duration, and Treatment with Calcium Chloride , 1988, Anesthesia and analgesia.