Evidence for distinct verbal memory pathologies in severely and mildly disturbed schizophrenics.

It is well known that schizophrenics have difficulty in effectively encoding verbal materials into their long-term memories and consequently show a deficit in recall. Recently, orienting tasks were introduced as a method for achieving equivalent to normal encoding and mnemonic organization in schizophrenics; consequently, their deficit in recall disappeared. A detailed review of the literature, however, showed that such effective orienting tasks had only been applied to mildly disturbed schizophrenics (nonchronic, in a good condition). This report presents three experiments which show that more severely disturbed (chronic, hospitalized) schizophrenics, unlike mildly disturbed patients, have memory deficits that cannot be located at the encoding stage. Severely disturbed schizophrenics show (1) a recall deficit, even after effective encoding and mnemonic organization are induced; (2) excessive forgetting over 24- and 48-hour periods; and (3) a recognition memory deficit. These deficits are in addition to their encoding deficit. The use of a matched-tasks check in experiments 2 and 3 suggests that this postencoding deficit is a differential deficit and does not is a differential deficit and does not simply reflect the schizophrenic generalized deficit. Theoretical implications, also supported by the use of various organizational indices (e.g., clustering, hierarchical clustering schemes, and hierarchical grouping analysis), are discussed.

[1]  T. A. Williams,et al.  Recognition in episodic long-term memory in schizophrenia. , 1977, Journal of clinical psychology.

[2]  E. Bauman Schizophrenic short-term memory: A deficit in subjective organization. , 1971 .

[3]  A. Maslow Motivation and Personality , 1954 .

[4]  Broen We,et al.  A theory of response interference in schizophrenia. , 1967 .

[5]  James W. Pellegrino,et al.  A general measure of organization in free recall for variable unit size and internal sequential consistency , 1971 .

[6]  Encoding processes and memory for categorically related words by schizophrenic patients. , 1980 .

[7]  S. D. Koh,et al.  Affective memory and schizophrenic anhedonia. , 1981, Schizophrenia bulletin.

[8]  D. Fowles,et al.  Conceptual ability, response interference, and arousal in withdrawn and active schizophrenics. , 1974, Journal of consulting and clinical psychology.

[9]  Wilcott Rc,et al.  Effects of chlorpromazine on learning and related processes in emotionally disturbed children. , 1963 .

[10]  C. L. Hull The Formation and Retention of Associations among the Insane , 1917 .

[11]  E. Bleuler Dementia Praecox, or the Group of Schizophrenias. New York (International Universities Press) 1950. , 1950 .

[12]  Andrew F. Monk,et al.  A NEW APPROACH TO THE CHARACTERIZATION OF SEQUENTIAL STRUCTURE IN MULTI‐TRIAL FREE RECALL USING HIERARCHICAL GROUPING ANALYSIS , 1976 .

[13]  R. A. Peterson,et al.  Affective encoding and consequent remembering in schizophrenic young adults. , 1976, Journal of abnormal psychology.

[14]  L. J. Chapman,et al.  The measurement of differential deficit. , 1978, Journal of psychiatric research.

[15]  G. A. Miller THE PSYCHOLOGICAL REVIEW THE MAGICAL NUMBER SEVEN, PLUS OR MINUS TWO: SOME LIMITS ON OUR CAPACITY FOR PROCESSING INFORMATION 1 , 1956 .

[16]  T. Crow,et al.  Molecular pathology of schizophrenia: more than one disease process? , 1980, British medical journal.

[17]  S. D. Koh,et al.  The structure of word storage in the permanent memory of nonpsychotic schizophrenics. , 1974, Journal of consulting and clinical psychology.

[18]  G. Bower,et al.  Human Associative Memory , 1973 .

[19]  R. A. Peterson,et al.  Encoding orientation and the remembering of schizophrenic young adults. , 1978, Journal of abnormal psychology.

[20]  D. Pearl Phenothiazine effects in chronic schizophrenia. , 1962, Journal of clinical psychology.

[21]  Donald E. Broadbent,et al.  Decision and stress , 1971 .

[22]  R. M. Schwartz Organization and recognition accuracy: The effect of context on blocked presentation , 1975 .

[23]  J. A. Horel The neuroanatomy of amnesia. A critique of the hippocampal memory hypothesis. , 1978, Brain : a journal of neurology.

[24]  P. Russell,et al.  Organization in memory: a comparison of psychotics and normals. , 1976, Journal of abnormal psychology.

[25]  Walter Kintsch,et al.  11 – Models for Free Recall and Recognition1 , 1970 .

[26]  K. Traupmann Effects of categorization and imagery on recognition and recall by process and reactive schizophrenics. , 1975, Journal of abnormal psychology.

[27]  S. Garfield,et al.  Effects of chlorpromazine on learning and related processes in emotionally disturbed children. , 1963, Journal of consulting psychology.

[28]  T. Crow,et al.  Subjective Age in Chronic Schizophrenia: Evidence for a Sub-Group of Patients with Defective Learning Capacity? , 1975, British Journal of Psychiatry.

[29]  James H. Johnson Memory and personality: An information processing approach , 1974 .

[30]  J. Lutz,et al.  The effect of a dual level word list on schizophrenic free recall. , 1981, Schizophrenia bulletin.

[31]  J. Haley An interactional description of schizophrenia. , 1959, Psychiatry.

[32]  John Brown,et al.  Recognition Assessed by D′ and by a Non-Parametric Alternative (the A-Index) as a Function of the Number of Choices , 1970 .

[33]  E. Tulving,et al.  Availability versus accessibility of information in memory for words , 1966 .

[34]  J. Lacey Somatic response patterning and stress : some revisions of activation theory , 1967 .

[35]  N. Vestre The effects of thorazine on learning and retention in schizophrenic patients. , 1961, Journal of abnormal and social psychology.

[36]  S. D. Koh Remembering of verbal materials by schizophrenic young adults. , 1978 .

[37]  J. Smith,et al.  Associative strength as a mode of organization in recall and recognition: a comparison of schizophrenics and normals. , 1975, Journal of abnormal psychology.

[38]  P. Daston Effect of two phenothiazine drugs on concentrative attention span of chronic schizophrenics. , 1959, Journal of clinical psychology.

[39]  S. C. Johnson Hierarchical clustering schemes , 1967, Psychometrika.

[40]  P. Venables,et al.  INPUT DYSFUNCTION IN SCHIZOPHRENIA. , 1964, Progress in experimental personality research.

[41]  Endel Tulving,et al.  Episodic memory: When recognition fails. , 1975 .

[42]  A. Routtenberg The two-arousal hypothesis: reticular formation and limbic system. , 1968, Psychological review.

[43]  E. Stengel CLINICAL PSYCHOPATHOLOGY , 1960 .

[44]  R. Kendell,et al.  ECT: II: Patients who Complain , 1980, British Journal of Psychiatry.

[45]  N. Cameron,et al.  Reasoning, regression and communication in schizophrenics. , 1938 .

[46]  A Ehrenfeucht,et al.  Organization of memory. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[47]  W. J. Barker The role of retrieval in schizophrenic memory deficit. , 1977 .

[48]  Wayne A. Wickelgren,et al.  Chunking and consolidation: A theoretical synthesis of semantic networks configuring in conditioning , 1979 .

[49]  Johnstone Ec,et al.  Dementia praecox and schizophrenia: was Bleuler wrong? , 1980 .

[50]  J. Kocsis,et al.  Memory Deficits in Depression: Evidence Utilizing the Wechsler Memory Scale , 1980, Perceptual and motor skills.

[51]  J. Feighner,et al.  Diagnostic criteria for use in psychiatric research. , 1972, Archives of general psychiatry.

[52]  P. Venables,et al.  Level of arousal and the subclassification of schizophrenia. , 1962, Archives of general psychiatry.

[53]  A. Mcghie,et al.  Perception of Speech in Schizophrenia , 1964, British Journal of Psychiatry.

[54]  J. D'eon,et al.  Hypnotic amnesia, disorganized recall, and inattention. , 1980, Journal of abnormal psychology.

[55]  S. D. Koh,et al.  Mnemonic organization in young nonpsychotic schizophrenics. , 1973, Journal of abnormal psychology.

[56]  G. Handelmann,et al.  Hippocampus, space, and memory , 1979 .

[57]  K. Traupmann Encoding processes and memory for categorically related words by schizophrenic patients. , 1980, Journal of abnormal psychology.

[58]  T. Crow,et al.  Age Disorientation in Chronic Schizophrenia: The Nature of the Cognitive Deficit , 1978, British Journal of Psychiatry.

[59]  W. Montague,et al.  Category norms of verbal items in 56 categories A replication and extension of the Connecticut category norms , 1969 .

[60]  M. Meehan The Transmission of Schizophrenia , 1969 .

[61]  H. J. Eysenck,et al.  Reminiscence, Motivation, and Personality: A Case Study in Experimental Psychology , 1977 .

[62]  E. Tulving,et al.  Organization of memory. , 1973 .

[63]  J. Spence,et al.  ASSOCIATIVE INTERFERENCE IN THE VERBAL LEARNING PERFORMANCE OF SCHIZOPHRENICS AND NORMALS. , 1964, Journal of abnormal psychology.

[64]  Endel Tulving,et al.  Encoding specificity and retrieval processes in episodic memory. , 1973 .

[65]  A. Rosen,et al.  Remembering of sentences by schizophrenic young adults. , 1980, Journal of abnormal psychology.

[66]  A. Monk,et al.  Sorting consistency as a diagnostic tool for schizophrenics and normals , 1980, Psychiatry Research.

[67]  Contributions to the psychopathology of schizophrenia : selected reprints, with new commentaries, from progress in experimental personality research , 1977 .

[68]  S. D. Koh,et al.  Memorization of "unrelated" word strings by young nonpsychotic schizophrenics. , 1974, Journal of abnormal psychology.

[69]  P. Venables Psychophysiology of abnormal behaviour. , 1981, British medical bulletin.

[70]  D. Wechsler Manual for the Wechsler Adult Intelligence Scale. , 1955 .

[71]  D. J. Murray,et al.  Recognition versus recall in schizophrenia. , 1968, Canadian journal of psychology.

[72]  L. J. Chapman,et al.  Disordered Thought in Schizophrenia , 1975 .

[73]  J. Davis,et al.  Comparative doses and costs of antipsychotic medication. , 1976, Archives of general psychiatry.

[74]  E. Bauman,et al.  Interference effects in schizophrenic short-term memory. , 1976, Journal of abnormal psychology.

[75]  H. S. Sullivan TENTATIVE CRITERIA OF MALIGNANCY IN SCHIZOPHRENIA , 1928 .

[76]  B. Cohen,et al.  Recall and recognition free learning in schizophrenics. , 1969, Journal of abnormal psychology.

[77]  S F Larsen,et al.  Mnemonic organization and free recall in schizophrenia. , 1976, Journal of abnormal psychology.