Peek-a-boo fragile site at 16d associated with Tourette syndrome, bipolar disorder, autistic disorder, and mental retardation.

Five patients with a fragile site at 16q22-23 and neuropsychiatric disorders are reported. Three of five had Tourette disorder, three had mental retardation, two had bipolar disorder, and one had autistic disorder. During our attempts to study the fragile sites in more detail we were unable to reproduce the fragile sites found several years earlier. The potential relationship between the fragile sites and the neuropsychiatric disorders in these patients is discussed. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:69-73, 2000.

[1]  C. Gunter,et al.  Eighth International workshop on the fragile X syndrome and X-linked mental retardation, August 16-22, 1997. , 1999, American journal of medical genetics.

[2]  M. Ivey,et al.  Two males with childhood disintegrative disorder: a prospective 14‐year outcome study , 1998, Developmental medicine and child neurology.

[3]  D. Paslier,et al.  Human Chromosomal Fragile Site FRA16B Is an Amplified AT-Rich Minisatellite Repeat , 1997, Cell.

[4]  Joseph Strayborn.  The Case of the Editor's Genie , 1996 .

[5]  L. Burd,et al.  Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[6]  L. Burd,et al.  Children with Fetal Alcohol Syndrome in North Dakota: a case control study utilizing birth certificate data , 1996, Addiction biology.

[7]  I. Simonic,et al.  Increased expression of aphidicolin-induced common fragile sites in Tourette syndrome: the key to understand the genetics of comorbid phenotypes? , 1996, American journal of medical genetics.

[8]  M. Klug,et al.  Comorbid Tourette's disorder and bipolar disorder: an etiologic perspective. , 1995, The American journal of psychiatry.

[9]  I. Simonic,et al.  Increased chromosomal breakage in Tourette syndrome predicts the possibility of variable multiple gene involvement in spectrum phenotypes: preliminary findings and hypothesis. , 1995, American journal of medical genetics.

[10]  S. Detera-Wadleigh,et al.  Genetic linkage mapping for a susceptibility locus to bipolar illness: chromosomes 2, 3, 4, 7, 9, 10p, 11p, 22, and Xpter. , 1994, American journal of medical genetics.

[11]  R. Stallings,et al.  FISH mapping of a human chromosome 16 constitutional pericentric inversion inv(16)(p13q22) found in a large kindred. , 1994, American journal of medical genetics.

[12]  L. Burd,et al.  Huntington disease and childhood-onset Tourette syndrome. , 1991, American journal of medical genetics.

[13]  L. Burd,et al.  A Possible Poststreptococcal Movement Disorder with Chorea and Tics , 1990, Developmental Medicine & Child Neurology.

[14]  L. Burd,et al.  A prevalence study of Rett syndrome in an institutionalized population. , 1990, American journal of medical genetics.

[15]  L. Burd,et al.  Differential responsiveness to lithium in patients with Tourette disorder , 1988, Neuroscience & Biobehavioral Reviews.

[16]  W. Fisher,et al.  Childhood Onset Pervasive Developmental Disorder. , 1988, Journal of child psychology and psychiatry, and allied disciplines.

[17]  D. Comings,et al.  A controlled study of Tourette syndrome. V. Depression and mania. , 1987, American journal of human genetics.

[18]  W. Fisher,et al.  A prevalence study of pervasive developmental disorders in North Dakota. , 1987, Journal of the American Academy of Child and Adolescent Psychiatry.

[19]  W. Fisher,et al.  Comparisons of DSM-III defined pervasive developmental disorders in North Dakota children. , 1987, Journal of the American Academy of Child and Adolescent Psychiatry.

[20]  W. Fisher,et al.  A prevalence study of Gilles de la Tourette syndrome in North Dakota school-age children. , 1986, Journal of the American Academy of Child Psychiatry.

[21]  W. Fisher,et al.  Prevalence of Gilles de la Tourette's syndrome in North Dakota adults. , 1986, The American journal of psychiatry.

[22]  G. Sutherland,et al.  A new location for the human adenine phosphoribosyltransferase gene (APRT) distal to the haptoglobin (HP) and fra(16)(q23)(FRA16D) loci. , 1986, Cytogenetics and cell genetics.

[23]  C. Gillberg,et al.  CHROMOSOME ABNORMALITIES IN INFANTILE AUTISM AND OTHER CHILDHOOD PSYCHOSES: A POPULATION STUDY OF 66 CASES , 1985, Developmental medicine and child neurology.

[24]  L. Burd,et al.  Gilles de la Tourette's syndrome and bipolar disorder. , 1984, Archives of neurology.

[25]  Sutherland Gr.  Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics. , 1979 .

[26]  F. Hecht,et al.  Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in Man , 1970, Science.