Reliability and Validity of the Korean Version of the Lymphedema Quality of Life Questionnaire in Breast Cancer-Related Lymphedema Patients.

Background: This study aimed to demonstrate the reliability and validity of the Korean version of the Lymphedema Quality of Life (LYMQOL) questionnaire. Methods and Results: This study was a multicentered cross-sectional survey of patients with breast cancer-related lymphedema. The LYMQOL-arm questionnaire was translated from English to Korean. This 28-item instrument contains the overall quality of life (QOL) and is categorized into four domains: function, appearance, symptoms, and mood. In addition, the demographics and characteristics of lymphedema were assessed by reviewing the medical records. The LYMQOL-arm, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), and Breast Cancer Module 23 (EORTC QLQ-BR23) were administered. The internal consistency of the LYMQOL-arm was analyzed using Cronbach's α, and test-retest reliability was examined using the intraclass correlation coefficient (ICC). Concurrent validity was evaluated using Pearson's correlation test between the LYMQOL-arm and the EORTC QLQ instruments. A total of 62 participants were enrolled in the study. All domains of the LYMQOL-arm showed high internal consistency, and the ICC of each domain and overall QOL ranged from 0.836 to 0.956 (p < 0.001). All domains and overall QOL scores of the LYMQOL-arm significantly correlated with most of the EORTC QLQ-C30 and EORTC QLQ-BR23 scales. Furthermore, it revealed a significant association with the degree of perceived edema. Conclusions: The Korean version of the LYMQOL-arm questionnaire has proven its reliability and validity in assessing QOL in patients with breast cancer-related lymphedema.

[1]  M. Monticone,et al.  Lymphedema quality of life questionnaire (LYMQOL): cross-cultural adaptation and validation in Italian women with upper limb lymphedema after breast cancer , 2021, Disability and rehabilitation.

[2]  P. Giovanoli,et al.  Patient-reported outcomes following lymph reconstructive surgery in lower limb lymphedema: a systematic review of literature. , 2020, Journal of vascular surgery. Venous and lymphatic disorders.

[3]  A. Klassen,et al.  Systematic Review of Patient-Reported Outcomes following Surgical Treatment of Lymphedema , 2020, Cancers.

[4]  S. Karahan,et al.  The Reliability and Validity of Lymphedema Quality of Life Questionnaire-Leg in Turkish Patients with Lower Limb Lymphedema. , 2020, Lymphatic research and biology.

[5]  David Liljequist,et al.  Intraclass correlation – A discussion and demonstration of basic features , 2019, PloS one.

[6]  I. Nevelsteen,et al.  Revision of the Lymphedema Functioning, Disability and Health Questionnaire for Upper Limb Lymphedema (Lymph-ICF-UL): Reliability and Validity. , 2019, Lymphatic research and biology.

[7]  M. Dietrich,et al.  Development and Validation of the Lymphedema Symptom Intensity and Distress Survey-Lower Limb. , 2018, Lymphatic research and biology.

[8]  K. Taber.  The Use of Cronbach’s Alpha When Developing and Reporting Research Instruments in Science Education , 2017, Research in Science Education.

[9]  R. R. van der Hulst,et al.  Quality of Life Questionnaires in Breast Cancer-Related Lymphedema Patients: Review of the Literature. , 2018, Lymphatic research and biology.

[10]  Y. Bakar,et al.  Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema. , 2017, European journal of breast health.

[11]  H. Neumann,et al.  Validation of the Lymphoedema Quality-of-Life Questionnaire (LYMQOL) in Dutch Patients Diagnosed with Lymphoedema of the Lower Limbs , 2016, Phlebology.

[12]  M. Dietrich,et al.  Development and validation of the Lymphedema Symptom and Intensity Survey-Arm , 2015, Supportive Care in Cancer.

[13]  L. Kristjanson,et al.  Lymphedema Quality of Life Inventory (LyQLI)-Development and investigation of validity and reliability , 2015, Quality of Life Research.

[14]  I. Vergote,et al.  Lymphoedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphoedema (Lymph-ICF-LL): Reliability and Validity , 2014, Physical Therapy.

[15]  M. Christiaens,et al.  Lymphoedema Functioning, Disability and Health Questionnaire (Lymph-ICF): Reliability and Validity , 2011, Physical Therapy.

[16]  A. Forner-Cordero,et al.  Predictive Factors of Response to Decongestive Therapy in Patients with Breast-Cancer-Related Lymphedema , 2010, Annals of Surgical Oncology.

[17]  C. Moffatt,et al.  Health‐related quality of life with lymphoedema: a review of the literature , 2005, International wound journal.