Clinical effectiveness of decitabine in severe sickle cell disease

precursors to the subsequent DLBCLs these patients develop. Several clonal B-cell populations may develop during the course of the disease, and these may be transient, with many disappearing subsequently. Hence, when a proportion of AITL patients subsequently develop a full-blown DLBCL or EBVcHL, one may or may not be able to establish clonal ancestry to ‘precursor’ cells seen in an earlier biopsy.