Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons

Significance Brain oscillations have long-lasting incidence on synaptic and intrinsic plasticity. For example, low-frequency stimulation at theta (θ; ∼5 Hz) frequency induces synaptic depression at glutamatergic synapses in principal glutamatergic neurons. However, the incidence of θ activity on synaptic transmission and intrinsic excitability in GABAergic interneurons is unknown. We show here that θ patterns of stimulation induce both synaptic and intrinsic potentiation in O-LM interneurons. While LTP requires the synaptic activation of CP-AMPAR, LTP-IE results from the mGluR1-dependent and PIP2-dependent down-regulation of both Kv7 and HCN channels. We conclude that θ activity has opposite effects on induced plasticity in glutamatergic and GABAergic neurons.

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