Thick-film multichannel biosensors for simulataneous amperometric and potentiometric measurements

A seven-channel multibiosensor for simultaneous amperometric and potentiometric operation is described. The tranducer is fabricated by screen-printing techniques in thick-film technology and contains 14 gold electrodes, which act as working and counter electrodes, and one silver electrode, which is chlorinated to give an integrated silver/silver chloride reference electrode. The ion-selective membranes are based on a poly(vinyl chloride)-poly(vinyl acetate) copolymer. Entrapment of enzymes is achieved by membranes made from organic-solvent-free aqueous polymer dispersions, which can be applied to the sensor electrodes by screen-printing or solder dispenser systems. The sensor is integrated into a flow-injection-analysis (FIA) system and is applied to the analysis of blood serum electrolyte (K+, Li+) and metabolite (glucose, urea, lactate) status.

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