Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

[1]  M. Lei,et al.  Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis , 2016, Oncogene.

[2]  F. Setién,et al.  A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families , 2015, Nature Communications.

[3]  M. Lei,et al.  SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates , 2015, Nucleic acids research.

[4]  R. Gibbs,et al.  Germline mutations in shelterin complex genes are associated with familial glioma. , 2015, Journal of the National Cancer Institute.

[5]  Dereje D. Jima,et al.  The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. , 2014, Blood.

[6]  Jianxin Shi,et al.  Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma , 2014, Nature Genetics.

[7]  Thomas M. Keane,et al.  POT1 loss-of-function variants predispose to familial melanoma , 2014, Nature Genetics.

[8]  Sandy Chang Cancer chromosomes going to POT1 , 2013, Nature Genetics.

[9]  A. López-Guillermo,et al.  POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia , 2013, Nature Genetics.

[10]  Leslie A. Leinwand,et al.  The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity , 2012, Nature.

[11]  E. Blackburn,et al.  The telomere syndromes , 2012, Nature Reviews Genetics.

[12]  M. Dong,et al.  Identification of cross-linked peptides from complex samples , 2012, Nature Methods.

[13]  K. Collins,et al.  Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme* , 2012, The Journal of Biological Chemistry.

[14]  A. Venteicher,et al.  TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends , 2012, Cell.

[15]  Maxim V. Petoukhov,et al.  New developments in the ATSAS program package for small-angle scattering data analysis , 2012, Journal of applied crystallography.

[16]  E. Giné,et al.  Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia , 2011, Nature Genetics.

[17]  Sandy Chang,et al.  TERRA and hnRNPA1 Orchestrate an RPA-to-POT1 Switch on Telomeric Single-Stranded DNA , 2010, Nature.

[18]  A. Multani,et al.  The function of classical and alternative non‐homologous end‐joining pathways in the fusion of dysfunctional telomeres , 2010, The EMBO journal.

[19]  Liisa Holm,et al.  Dali server: conservation mapping in 3D , 2010, Nucleic Acids Res..

[20]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[21]  T. Cech,et al.  Functional interaction between telomere protein TPP1 and telomerase. , 2010, Genes & development.

[22]  I. Polikarpov,et al.  Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale , 2010 .

[23]  Randy J. Read,et al.  Acta Crystallographica Section D Biological , 2003 .

[24]  Detlef Snakenborg,et al.  BioXTAS RAW, a software program for high‐throughput automated small‐angle X‐ray scattering data reduction and preliminary analysis , 2009 .

[25]  M. Armanios Syndromes of telomere shortening. , 2009, Annual review of genomics and human genetics.

[26]  Dmitri I. Svergun,et al.  Electronic Reprint Applied Crystallography Dammif, a Program for Rapid Ab-initio Shape Determination in Small-angle Scattering Applied Crystallography Dammif, a Program for Rapid Ab-initio Shape Determination in Small-angle Scattering , 2022 .

[27]  Wilhelm Palm,et al.  Functional Dissection of Human and Mouse POT1 Proteins , 2008, Molecular and Cellular Biology.

[28]  Sandy Chang,et al.  Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis , 2007, The EMBO journal.

[29]  J. Shay,et al.  Human diseases of telomerase dysfunction: insights into tissue aging , 2007, Nucleic acids research.

[30]  T. Lange,et al.  Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 , 2007, Nature.

[31]  G. Hammer,et al.  Telomere protection by mammalian Pot1 requires interaction with Tpp1 , 2007, Nature Structural &Molecular Biology.

[32]  Dan Liu,et al.  TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase , 2007, Nature.

[33]  T. Cech,et al.  The POT1–TPP1 telomere complex is a telomerase processivity factor , 2007, Nature.

[34]  A. Multani,et al.  POT1b protects telomeres from end‐to‐end chromosomal fusions and aberrant homologous recombination , 2006, The EMBO journal.

[35]  Wladek Minor,et al.  HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. , 2006, Acta crystallographica. Section D, Biological crystallography.

[36]  J. Deng,et al.  Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres , 2006, Cell.

[37]  T. Lange,et al.  Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres , 2006, Cell.

[38]  T. Lange,et al.  Shelterin: the protein complex that shapes and safeguards human telomeres , 2005 .

[39]  T. Cech,et al.  Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection , 2004, Nature Structural &Molecular Biology.

[40]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[41]  Susan Smith,et al.  A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2 , 2004, Current Biology.

[42]  B. Chait,et al.  POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. , 2004, Genes & development.

[43]  Jun Qin,et al.  PTOP interacts with POT1 and regulates its localization to telomeres , 2004, Nature Cell Biology.

[44]  D. Loayza,et al.  DNA Binding Features of Human POT1 , 2004, Journal of Biological Chemistry.

[45]  T. Cech Beginning to Understand the End of the Chromosome , 2004, Cell.

[46]  T. Simonsson A substrate for telomerase. , 2003, Trends in biochemical sciences.

[47]  P. Baumann,et al.  DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA , 2003, Nature.

[48]  Dmitri I. Svergun,et al.  PRIMUS: a Windows PC-based system for small-angle scattering data analysis , 2003 .

[49]  Dmitri I. Svergun,et al.  Uniqueness of ab initio shape determination in small-angle scattering , 2003 .

[50]  P. Baumann,et al.  Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative Splicing , 2002, Molecular and Cellular Biology.

[51]  T. Hughes,et al.  Conserved Structure for Single-Stranded Telomeric DNA Recognition , 2002, Science.

[52]  T. Lange Protection of mammalian telomeres , 2002, Oncogene.

[53]  P. Baumann,et al.  Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans , 2001, Science.

[54]  K. Komori,et al.  Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition. , 2001, Structure.

[55]  Lynda Chin,et al.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice , 2000, Nature.

[56]  J. Shay,et al.  Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang* , 2000, The Journal of Biological Chemistry.

[57]  W. Hahn,et al.  Inhibition of telomerase limits the growth of human cancer cells , 1999, Nature Medicine.

[58]  M. Robinson,et al.  Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. , 1999, Genes & development.

[59]  C. Greider Telomeres Do D-Loop–T-Loop , 1999, Cell.

[60]  J. Griffith,et al.  Mammalian Telomeres End in a Large Duplex Loop , 1999, Cell.

[61]  M. Horvath,et al.  Crystal Structure of the Oxytricha nova Telomere End Binding Protein Complexed with Single Strand DNA , 1998, Cell.

[62]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[63]  J. Shay,et al.  Normal human chromosomes have long G-rich telomeric overhangs at one end. , 1997, Genes & development.

[64]  J. Langmore,et al.  Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening , 1997, Cell.

[65]  D. Shore,et al.  Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. , 1994, Genes & development.

[66]  Dmitri I. Svergun,et al.  Determination of the regularization parameter in indirect-transform methods using perceptual criteria , 1992 .

[67]  Carol W. Greider,et al.  The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity , 1987, Cell.