[The influence of fatty acids on thyroxine and 3, 3'-diiodothyronine levels in patients with chronic renal failure on hemodialysis (author's transl)].

To evaluate the influence of hemodialysis on the determinations of iodothyronine concentrations, serum and plasma concentrations of thyroxine (T4), 3, 5, 3'-triiodothyronine (T3), 3, 3', 5'-triiodothyronine (rT3), and 3, 3'-dii.odothyronine (3, 3'-T2), as well as total protein and non-esterified fatty acids (NEFA), were determined in 8 patients with chronic renal failure on hemodialysis. Serum samples were taken before the regular dialysis, and plasma samples during the dialysis were taken about 10 minutes after the beginning and just before the end of dialysis. T4 was determined by competitive protein binding assay (CPBA) and radioimmunoassay (RIA), and T3 rT3 and 3, 3'-T2 levels were determined by RIA. Total protein concentrations were 7.0 ± 0.1 (mean ± SE) g/dl before the dialysis, decreased to 6.3 ± 0.3 g/dl about 10 minutes after the beginning of the dialysis, and then in-

[1]  D. Sherrard,et al.  Thyroid function and lipids in patients with chronic renal disease treated by hemodialysis: with comments on the "free thyroxine index". , 1979, Metabolism: clinical and experimental.

[2]  J. Hershman,et al.  Thyroid function in patients undergoing maintenance hemodialysis: unexplained low serum thyroxine concentration. , 1978, Metabolism: clinical and experimental.

[3]  J. Bennett,et al.  Increased concentrations of serum free fatty acids falsely increase serum thyroxine as determined by competitive protein-binding. , 1977, Clinical chemistry.

[4]  P. Davis,et al.  Thyroid function and metabolic state in chronic renal failure. , 1976, Annals of internal medicine.

[5]  F. Spierto,et al.  A comparison of the interference of fatty acids in the competitive binding radioassay and radioimmunoassay for serum T4. , 1976, Clinica chimica acta; international journal of clinical chemistry.

[6]  T. Helenius,et al.  Effect of fatty acids on thyroid function tests in vitro and in vivo. , 1976, Clinica chimica acta; international journal of clinical chemistry.

[7]  P. Czernichow,et al.  Abnormal TSH, PRL and GH response to TSH releasing factor in chronic renal failure. , 1976, The Journal of clinical endocrinology and metabolism.

[8]  F. Spierto,et al.  Interference of fatty acids in the competitive protein-binding assay for serum thyroxine. , 1976, Clinical chemistry.

[9]  K. Rootwelt.  The influence of fatty acids on serum thyroxine determination by competitive protein-binding radioassay. , 1975, Scandinavian journal of clinical and laboratory investigation.

[10]  W. Jubiz,et al.  Thyroid abnormalities in renal failure. A study of 53 patients on chronic hemodialysis. , 1973, Annals of internal medicine.

[11]  D. Silverberg,et al.  Effects of chronic hemodialysis on thyroid function in chronic renal failure. , 1973, Canadian Medical Association journal.

[12]  J. Seth.  Work simplification of a competitive protein binding analysis for serum thyroxine, and a study of some laboratory factors affecting assay results. , 1973, Clinica chimica acta; international journal of clinical chemistry.

[13]  C. M. Jones,et al.  Reciprocal changes in serum thyrotropin and free thyroxine produced by heparin. , 1972, The Journal of clinical endocrinology and metabolism.

[14]  G. M. Breneman,et al.  Observations on the effect of heparin on free and total thyroxine. , 1971, The Journal of clinical endocrinology and metabolism.