Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways.

[1]  J. Graff,et al.  The casein kinase I family in Wnt signaling. , 2001, Developmental biology.

[2]  L. Swenson,et al.  Structure of GSK3β reveals a primed phosphorylation mechanism , 2001, Nature Structural Biology.

[3]  Laurence H. Pearl,et al.  Crystal Structure of Glycogen Synthase Kinase 3β Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition , 2001, Cell.

[4]  P. Cohen,et al.  A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. , 2001, Molecular Cell.

[5]  P. Cowin,et al.  Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland , 2001, The Journal of cell biology.

[6]  A. Cadoret,et al.  Hepatomegaly in Transgenic Mice Expressing an Oncogenic Form of β-Catenin , 2001 .

[7]  A. Reith,et al.  Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. , 2001 .

[8]  René Hen,et al.  Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice , 2001 .

[9]  Arnold J. Levine,et al.  Identification of a Mouse Homolog of the Human BTEB2Transcription Factor as a β-Catenin-Independent Wnt-1-Responsive Gene , 2001, Molecular and Cellular Biology.

[10]  J L Cleveland,et al.  Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. , 2000, Genes & development.

[11]  Ming-tao Li,et al.  Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β , 2000, Molecular and Cellular Biology.

[12]  Raymond L. White,et al.  APC‐mediated downregulation of β‐catenin activity involves nuclear sequestration and nuclear export , 2000, EMBO reports.

[13]  F. McCormick,et al.  Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling* , 2000, The Journal of Biological Chemistry.

[14]  B. Henderson Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover , 2000, Nature Cell Biology.

[15]  P. Polakis Wnt signaling and cancer. , 2000, Genes & development.

[16]  J. Woodgett,et al.  Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation , 2000, Nature.

[17]  R. Kemler,et al.  Curbing the nuclear activities of β‐catenin , 2000 .

[18]  A. Levine,et al.  WISP-1 is a Wnt-1- and β-catenin-responsive oncogene , 2000, Genes & Development.

[19]  A. Kimmel,et al.  The Novel Tyrosine Kinase ZAK1 Activates GSK3 to Direct Cell Fate Specification , 1999, Cell.

[20]  M. Taketo,et al.  Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene , 1999, The EMBO journal.

[21]  J. Graff,et al.  Casein kinase I transduces Wnt signals , 1999, Nature.

[22]  R. Kucherlapati,et al.  Mouse models for colorectal cancer , 1999, Oncogene.

[23]  P. Cohen,et al.  A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin , 1999, FEBS letters.

[24]  R. Nusse,et al.  A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. , 1999, Development.

[25]  J Mao,et al.  Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1 , 1999, The EMBO journal.

[26]  J. Woodgett,et al.  Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos* , 1999, The Journal of Biological Chemistry.

[27]  Akira Kikuchi,et al.  DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability , 1999, Molecular and Cellular Biology.

[28]  Inder M. Verma,et al.  Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene , 1999 .

[29]  Elaine Fuchs,et al.  A common human skin tumour is caused by activating mutations in β-catenin , 1999, Nature Genetics.

[30]  Frank McCormick,et al.  β-Catenin regulates expression of cyclin D1 in colon carcinoma cells , 1999, Nature.

[31]  M. Mann,et al.  Identification of the receptor component of the IκBα–ubiquitin ligase , 1998, Nature.

[32]  E. Fuchs,et al.  De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin , 1998, Cell.

[33]  M. Roussel,et al.  Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.

[34]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[35]  M. Boutros,et al.  Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling , 1998, Cell.

[36]  D. M. Ferkey,et al.  GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis , 1998, Cell.

[37]  G. Struhl,et al.  Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb , 1998, Nature.

[38]  R. Nusse,et al.  Wnt signaling: a common theme in animal development. , 1997, Genes & development.

[39]  Philip R. Cohen,et al.  Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216 , 1997, FEBS letters.

[40]  U. Wagner,et al.  Tau phosphorylation in transgenic mice expressing glycogen synthase kinase‐3β transgenes , 1997, Neuroreport.

[41]  Wei Hsu,et al.  The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation , 1997, Cell.

[42]  A. M. Møller,et al.  Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM , 1997, Diabetologia.

[43]  H. Varmus,et al.  Casein kinase 2 associates with and phosphorylates Dishevelled , 1997, The EMBO journal.

[44]  A. Berns,et al.  Activation of a novel proto‐oncogene, Frat1, contributes to progression of mouse T‐cell lymphomas , 1997, The EMBO journal.

[45]  N. Perrimon,et al.  The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. , 1996, Genes & development.

[46]  G. Struhl,et al.  Direct and Long-Range Action of a Wingless Morphogen Gradient , 1996, Cell.

[47]  J. Woodgett,et al.  Wingless inactivates glycogen synthase kinase‐3 via an intracellular signalling pathway which involves a protein kinase C. , 1996, The EMBO journal.

[48]  Jeremy Nathans,et al.  A new member of the frizzled family from Drosophila functions as a Wingless receptor , 1996, Nature.

[49]  C. Neumann,et al.  Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing. , 1996, Development.

[50]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[51]  David Baltimore,et al.  Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB , 1995, Nature.

[52]  J. Klingensmith,et al.  The dishevelled protein is modified by wingless signaling in Drosophila. , 1995, Genes & development.

[53]  Harold E. Varmus,et al.  Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos , 1995, Nature.

[54]  J. Klingensmith,et al.  Signaling by wingless in Drosophila. , 1994, Developmental biology.

[55]  J. Woodgett,et al.  Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. , 1994, The Biochemical journal.

[56]  A. M. Arias,et al.  The wingless signalling pathway and the patterning of the wing margin in Drosophila. , 1994, Development.

[57]  Norbert Perrimon,et al.  dishevelled and armadillo act in the Wingless signalling pathway in Drosophila , 1994, Nature.

[58]  Norbert Perrimon,et al.  Components of wingless signalling in Drosophila , 1994, Nature.

[59]  N. Perrimon,et al.  Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. , 1993, The EMBO journal.

[60]  P. Cohen,et al.  Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. , 1993, The Biochemical journal.

[61]  M. Krasnow,et al.  Intercellular signalling in Drosophila segment formation reconstructed in vitro , 1993, Nature.

[62]  V. Pantesco,et al.  Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch , 1993, Nature.

[63]  V. Pantesco,et al.  Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila. , 1993, The EMBO journal.

[64]  J. Woodgett,et al.  Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation. , 1993, The EMBO journal.

[65]  M. Bate,et al.  A wingless-dependent polar coordinate system in Drosophila imaginal discs. , 1993, Science.

[66]  H. Varmus,et al.  Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[67]  N. Perrimon,et al.  wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate , 1992, Cell.

[68]  P. Lawrence,et al.  The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. , 1992, Development.

[69]  H. Varmus,et al.  The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells , 1992, Molecular and cellular biology.

[70]  H. Varmus,et al.  Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice , 1992, Molecular and cellular biology.

[71]  A. M. Arias,et al.  Secretion and movement of wingless protein in the epidermis of the Drosophila embryo , 1991, Mechanisms of Development.

[72]  H. Varmus,et al.  A new nomenclature for int-1 and related genes: The Wnt gene family , 1991, Cell.

[73]  P. Simpson,et al.  An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. , 1990, The EMBO journal.

[74]  J. Woodgett,et al.  Molecular cloning and expression of glycogen synthase kinase‐3/factor A. , 1990, The EMBO journal.

[75]  Norbert Perrimon,et al.  Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3 , 1990, Nature.

[76]  H. Tung,et al.  Purification and characterization of protein phosphatase 1I activating kinase from bovine brain cytosolic and particulate fractions. , 1989, The Journal of biological chemistry.

[77]  N. Perrimon,et al.  Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome. , 1989, Genetics.

[78]  H. Varmus,et al.  Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice , 1988, Cell.

[79]  Judith A. Kassis,et al.  Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis , 1988, Nature.

[80]  E. Wieschaus,et al.  Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis , 1987, Cell.

[81]  Harold E. Varmus,et al.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.

[82]  P. Cohen,et al.  Purification of glycogen synthase kinase 3 from rabbit skeletal muscle. Copurification with the activating factor (FA) of the (Mg-ATP) dependent protein phosphatase. , 1981, European journal of biochemistry.

[83]  P. Cohen,et al.  Glycogen synthase kinase-3 from rabbit skeletal muscle. , 1981, Methods in enzymology.

[84]  W. Merlevede,et al.  ATP x Mg-dependent protein phosphatase from rabbit skeletal muscle. II. Purification of the activating factor and its characterization as a bifunctional protein also displaying synthase kinase activity. , 1980, The Journal of biological chemistry.

[85]  P. Lawrence,et al.  The development of wingless, a homeotic mutation of Drosophila. , 1977, Developmental biology.

[86]  T. Dale,et al.  Wnt Signalling in Mammalian Development and Cancer , 2004, Cancer and Metastasis Reviews.

[87]  L. Williams,et al.  New steps in the Wnt/beta-catenin signal transduction pathway. , 2000, Recent progress in hormone research.

[88]  R. Nusse,et al.  Mechanisms of Wnt signaling in development. , 1998, Annual review of cell and developmental biology.

[89]  N. Perrimon,et al.  The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. , 1994, Genes & development.

[90]  A. Brown,et al.  Wingless, the Drosophila homolog of the proto-oncogene Wnt-1, can transform mouse mammary epithelial cells. , 1993, Development (Cambridge, England). Supplement.

[91]  J. Woodgett,et al.  Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product. , 1992, European journal of biochemistry.